Lipomatous tumours of the head and neck: a spectrum of biological behaviour

Bree, Eelco de; Karatzanis, Alexander D.; Hunt, Jennifer L.; Strojan, Primož; Rinaldo, Alessandra; Takes, Robert P.; Ferlito, Alfio; Bree, Remco de

doi:10.1007/s00405-014-3065-8

Cited by 39 publications

(17 citation statements)

References 116 publications

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“…Davis 12 and Dubin 22 pointed out a possible role of adjuvant radiation therapy (RT) in reducing the rate of local recurrences. However, the effectiveness of adjuvant RT in treating liposarcomas and DDL in particular, is still controversial; several studies showed as adjuvant radiotherapy reduces the rate of local recurrence from 60% to 40%, but it does not modify the overall survival or the rate of metastasis 1, 2, 5. In our case adjuvant radiotherapy was warranted because of the aggressive histology pattern (high grade rabdo-myosarcoma and pleomorphic sarcoma) and the inability to obtain a wide resection margin.…”

Section: Discussionmentioning

confidence: 74%

“…Sarcomas of the head and neck region represent rare pathology in adults (accounting for 2–10% of all cancers), while they are more frequent in the pediatric population (35%) 1, 2. Head and neck liposarcomas (HNLS) account for less than 5% of liposarcomas 3 and 2–9% of all sarcomas arising in the region 4, 5, 6, 7, 8, 9, 10, 11, 12.…”

Section: Discussionmentioning

confidence: 99%

“…The first choice of treatment is complete surgical removal. Because DDL have an aggressive behavior, with a local recurrence rate of 41%, disease specific (DS) mortality of 28%, and because the fascia surrounding the mass it is not a true capsule, recommendations are to keep surgical dissection with wide negative margins of at least 2 cm from the margin of the lesion, when feasible 1, 2, 11. Neck dissection is usually not required because of the extreme rarity of lymph node metastases 11 .…”

Section: Discussionmentioning

confidence: 99%

“…Sarcomas are rare neoplasms representing less than 1% of all malignancies; of those, liposarcoma (LS) is one of the most common soft tissue sarcomas occurring in adults (about 20% of all sarcomas) 1, 2, 3. Most of liposarcomas are located in deep soft tissue of lower extremities, retroperitoneum and mesenteric region; while less than 5% occur in head and neck region 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12. According to the World Health Organization classification of soft tissue tumours, and the classification of Enzinger and Weis, five categories of liposarcomas are recognised: well differentiated, myxoid, dedifferentiated, round cell and pleomorphic 13, 14.…”

Section: Introductionmentioning

confidence: 99%

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Primary dedifferentiated liposarcoma of the orbit, a rare entity: Case report and review of literature

Torroni

Gasparini

Longo

et al. 2019

Saudi Journal of Ophthalmology

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Head and neck liposarcomas are rare entities accounting for less than 5% of all liposarcomas. The primary orbital location is even rarer, with about 40 cases described in the English literature. According with the widely accepted classification of Enzinger and Weis there are 5 histologic variants of liposarcomas: well differentiated, myxoid, dedifferentiated, round cell and pleomorphic. The first two are considered low-grade and display a favourable prognosis (>90% 5-year DSS and OS), whereas the dedifferentiated, round cell, and pleomorphic are defined high-grade and burdened with poorer prognosis (5-year DSS ranging 45–73%). Dedifferentiated liposarcomas (DDL) of the head and neck region are exceedingly rare, therefore there are scattered and contrasting data regarding their clinical history, treatment modality, and prognosis. We presented a case of DDL arising in the the left orbit (fourth case of primary orbital DDL described), free from disease after 5-year follow-up. Clinical history, treatment, and characteristics of the presented case were described and discussed in the light of how reported in the literature, in the attempt to bring further insight in the nature and management of this rare pathological entity.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Primary dedifferentiated liposarcoma of the orbit, a rare entity: Case report and review of literature

Torroni

Gasparini

Longo

et al. 2019

Saudi Journal of Ophthalmology

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“…Although indeed in some cases of lipomatous tumors cytogenetic analysis might be helpful in their differential diagnosis, it is definitely not a standard procedure in cases in which the histological diagnosis is not in doubt [2,3]. Moreover, cytogenetic analysis is of limited value in the case of spindle cell lipoma.…”

Section: Dear Editormentioning

confidence: 99%

Letter to the Editor Re: Co-existence of intramuscular spindle cell lipoma with an intramuscular ordinary lipoma: Report of a case Ivan Chernev, Shane Mctighe, Dirk P. Stanley

Laliotis

Bree²,

Vasilaki³

et al. 2014

pjp

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Dear Editor,We read the Letter to the Editor submitted by Chernev et al., in which the authors challenge the description of our case which concerned the co-existence of an intramuscular spindle cell lipoma with an intramuscular ordinary lipoma with great interest [1]. It is quite unusual to question so intensely data which have been presented by colleagues. Certainly, our description of this rare case only includes data of complete verity.Chernev et al. contend that since no MRI of the ordinary lipoma was provided, its anatomical relationship with the spindle cell lipoma had not been demonstrated. Since the number of figures in a case report is usually limited, simply mentioning its image findings in the manuscript should be considered sufficient Thus, we had not included radiographic images of the ordinary lipoma in our manuscript. As described, the synchronous existence of both lesions was initially detected at a CT scan made for staging, as sarcoma was suspected after core needle biopsy. Unfortunately, we cannot provide an appropriate 3D reconstruction of the area of interest, since we have only films and no digital CT scan file. However, the ordinary CT films provide clear evidence that this case concerns two different chest wall tumors ( Fig. 1A-H of this response letter).Further, Chernev et al. questioned whether the spindle cell lipoma was intramuscular, as noted in our manuscript, and suggest that its localization might be intermuscular instead. As demonstrated in Fig. 1 (MRI) and 2 (surgical specimen) of our case report, the lesion was evidently intramuscular. This observation can be further supported by Fig. 1A and 1B of this response letter.The authors of the Letter to the Editor expressed their interest in the type of the ordinary lipoma. We had not specified whether the lipoma was well-circumscribed or infiltrative, since we considered this fact of minor importance. However, for their information, it concerned a well-circumscribed type (Fig. 2 of this response letter) which had been simply enucleated out of its pseudocapsule during the surgical procedure.Subsequently, we cordially thank Chernev et al. for their comment that the other four cases with concurrent spindle cell and ordinary lipoma, which have been previously published and are referred to in the discussion of our manuscript, concern cases with subcutaneous or unspecified localization of the spindle cell lipoma or with existence of a spindle cell lipoma in an intramuscular ordinary lipoma in a single lesion. Their observation makes our presented case all the more rare and unique due to the co-existence of intramuscular spindle cell lipoma and intramuscular ordinary lipoma as two separated masses in one patient.The authors of the Letter to the Editor suggested that cytogenetic analysis of the spindle cell lipoma should have been performed. Although indeed in some cases of lipomatous tumors cytogenetic analysis might be helpful in their differential diagnosis, it is definitely not a standard procedure in cases in which the histological dia...

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