Lipopeptides: Biosynthesis and Applications

Walia, Navpreet Kaur

doi:10.4172/1948-5948.1000189

Cited by 6 publications

(7 citation statements)

References 41 publications

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“…Kiran et al [35] studied on the functional groups of rhamnolipids from the sponges and Aspergillus sp. Walaa et al, [16] determined the free -OH stretching at 3430 cm -1 , the C-H stretching vibrations of CH2 and CH3 groups at 2938 cm -1 , C=O from ester and carboxylic groups that were observed at 1739 cm -1 and 1629 cm -1 respectively.…”

Section: Discussionmentioning

confidence: 99%

Bioremediation and Biodegrdation of Oil by Biosurfactants

2023

JCBSC

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The energy resources mainly in petroleum and petroleum hydrocarbons are major pollutants of the environment. The oil and oil products contamination may cause severe harm and hence the attention has remaindered in the development of alternate technologies for elimination of contaminants. Biosurfactants were used in the remediation of oil pollution due to advantages such as biodegradability a low toxicity. Microbial surfactants are amphiphilic compounds produced in living species or excreted extracellular hydrophobic and hydrophilic moieties that confer on the organism the ability to accumulate between fluid phases thus reducing surface and interfacial tension. The present study was focused to isolate biosurfactant producing bacteria, screening, stability and identification of that compound and its biodegrading capacity.

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Section: Discussionmentioning

confidence: 99%

Bioremediation and Biodegrdation of Oil by Biosurfactants

2023

JCBSC

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“…Several strains from this genus are known to produce a wide variety of biocontrol metabolites, including ribosomally synthesized antimicrobial peptides (bacteriocins) as well as non-ribosomally synthesized peptides (NRPs) and polyketides (PKs) (Zhao and Kuipers 2016). NRPS, PKS or hybrid NPRS/PKS genes from Bacillus strains usually encode lipopeptide compounds mainly known for their antifungal properties such as iturins, fengycins and bacillomycin (Walia and Cameotra 2015). Lou et al (2014) confirmed the contribution of lipopeptides bacillomycin L and surfactin, produced by Bacillus subtilis 916, in controlling sheath blight in rice plants caused by Rhizoctonia solani.…”

Section: Discussionmentioning

confidence: 99%

Journal of Plant Protection Research

Wiraswati,

Rusmana,

Nawangsih

et al. 2019

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Rice blast is the main disease of rice plants in Indonesia and several countries worldwide. Controlling this disease using chemical fungicides has harmful effects on the environment. Therefore, we need biocontrol agents which are more environmentally friendly such as rice phyllosphere bacteria. This study aimed to explore bacteria producing bioactive compounds from the rice phyllosphere environment to control blast disease. A total of 88 isolates were successfully isolated from rice leaves in Sukabumi, Situgede, and Jasinga (West Java, Indonesia). From them, we obtained 22 bacteria isolates with antifungal activity against Pyricularia oryzae in vitro assay. In addition, seven non-pathogenic bacteria were obtained from further screening in hypersensitivity, hemolysis and pathogenicity assays, namely STGG 3, STGG 7, STGG 8, STGG 14, SKBV 1, STGV 8, and SKBG 78. To show their antifungal activity, we tested crude extracts of these seven isolates and the results revealed that all the crude extracts can inhibit the growth of P. oryzae. Based on a genetic approach, isolates STGG 3, STGG 7, and STGG 14 were found to have both nonribosomal peptide synthetases (NRPS) and polyketide synthases (PKS) genes, while isolate SKBV 1 only had the NRPS gene. The NRPS and PKS genes from potential isolates were similar to NRPS and PKS genes of Bacillus sp. in different strains. Furthermore, molecular identification based on the 16S rRNA gene revealed that the seven potential isolates belong to three genera, i.e. Bacillus (STGG 3, STGG 7, STGG 8, STGG 14, SKBV 1), Enterobacter (STGV 8) and Brachybacterium (SKBG 78). We suggest that the seven isolates found in this study have potency and could be recommended as biocontrol agents of blast disease caused by P. oryzae.

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“…(5) After reduction of the methanol phase, a defatting step had to be performed using n-hexane as well as the following devices: Ultrasonic bath (Sonorex Super RK 100 H, Bandelin electronic GmbH & Co. KG, Germany), separator funnel (500 mL, Lenz Laborglas GmbH & Co. KG, Germany), Buchner funnel (Duran Buchner funnel, Merck, Germany) with cellulose filter (Whatman cellulose filter, Merck, Germany) and a filter funnel (POR 5, DWK Life Sciences GmbH, Germany). (6) The preparative HPLC was performed with a JASCO system. For separation, a C18 column was used (Eurospher EI 100-10 C18 Column 250 × 32 mm, Knauer Wissenschaftliche Geräte GmbH, Germany).…”

Section: Process Units For Jagaricin Purificationmentioning

confidence: 99%

“…Owing to this characteristic, lipopeptides have various physicochemical properties such as emulsification/de‐emulsification, dispersing, foaming, viscosity reducing, solubilizing and mobilizing agents, and pore‐forming capacity [ 1 ]. Additionally, lipopeptides show diverse biological activities such as antimicrobial, antiviral, hemolytic, and insecticidal effects [ 1 , 5 , 6 ]. With properties such as eco‐friendliness, specificity, low toxicity, stability in varying environmental conditions, and chemical diversity, some microbial biosurfactants stand the chance of replacing synthetic surfactants in industrial applications soon [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Scalable downstream method for the cyclic lipopetide jagaricin

Stein

Schlosser

Bardl

et al. 2021

Engineering in Life Sciences

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Cyclic lipopeptides are substances with a high potential to act as antimicrobial agents. Jagaricin, produced by Janthinobacterium agaricidamnosum DSM 9628 and discovered in 2012, is a new member of this class with promising antifungal properties. However, further experiments to investigate future applications and/or conduct chemical derivatization to change properties and toxicity are impossible due to the limited access to jagaricin. Besides a high jagaricin concentration at the end of the fermentation process, a suitable downstream process is essential to generate appropriate amounts with the desired purity. In contrast to other amphiphilic molecules, jagaricin cannot be separated by foam fractionation since it is mainly attached to the surface of the microbial biomass. This technical report presents an overall process chain consisting of 11 individual steps to generate jagaricin in gram scale with a purity of over 95%.

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Lipopeptides: Biosynthesis and Applications

Cited by 6 publications

References 41 publications

Bioremediation and Biodegrdation of Oil by Biosurfactants

Bioremediation and Biodegrdation of Oil by Biosurfactants

Journal of Plant Protection Research

Scalable downstream method for the cyclic lipopetide jagaricin

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