Lipoperoxidation and antioxidant enzymes activity in pregnancy complicated with hypertension

Loverro, Giuseppe; Greco, Pantaleo; Capuano, Fernando; Carone, Domenico; Cormio, Gennaro; Selvaggi, Luigi

doi:10.1016/s0301-2115(95)02561-8

Cited by 65 publications

(37 citation statements)

References 17 publications

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“…Klapcinska et al [19] evaluated the index of "total antioxidant potential" (POTAOX), calculated as a sum of standardized values of individual antioxidant species. Earlier, Loverro et al [18] described "proantioxidant coefficient" calculated from the mean values of TBARS, CAT, GPx, and SOD. The additional cysteine derivatives intake by athletes in the present study increased in a resting concentration of plasma protein thiols in the NAC and LIP groups.…”

Section: Discussionmentioning

confidence: 99%

“…The application of Loverro's coefficient [18] enables not only an analysis of pro-antioxidant equilibrium, but also an evaluation of antioxidant effectiveness in athletes.…”

Section: Discussionmentioning

confidence: 99%

“…The pro-antioxidant (P/A) ratio was determined from the mean values of TBARS, SOD, GPx, and CAT according to Loverro et al [18]: P/A = TBARS/(SOD + GPx + CAT) The lactate (LA) concentration in the whole blood was assessed using a Dr. Lange kit (Germany).…”

Section: Methodsmentioning

confidence: 99%

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Effect of Cysteine Derivatives Administration in Healthy Men Exposed to Intense Resistance Exercise by Evaluation of Pro-Antioxidant Ratio

2007

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Abstract:The aim of this study was to ascertain the influence of cysteine derivatives on pro-antioxidant equilibrium and to compare the antioxidant effectiveness of N-acetylcysteine, α-lipoic acid, and taurine by using Loverro's coefficient (pro-antioxidant ratio) in healthy men exposed to intensity-resistance exercise. Fifty-five men were randomly assigned to one of four groups: control (CON, placebo), N-acetylcysteine (NAC 1.8 g·day -1 , 3 days), α-lipoic acid (LIP 1.2 g·day -1 , 3 days), or taurine (TAU 3 g·day -1 , 3 days). The erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities, lipid peroxidation products (TBARS), and plasma protein thiol concentrations were evaluated. The P/A ratio was determined from the mean values of TBARS, SOD, GPx, and CAT. The applied exercise at maximal intensity induced the significant changes in pro-antioxidant equilibrium toward peroxidation, which was proved by a 25% increase in TBARS concentration in the CON group. The peroxidation was significantly diminished by NAC (-14%) and LIP (-16%), whereas TAU had no effect on the TBARS concentration. Cysteine derivatives administration prevented exercise-induced decline in SOD activity and increased in GPx activity during exercise. CAT activity changed only in the LIP group. The estimation of P/A ratio showed the lowest level of pro-antioxidant equilibrium after LIP administration. In the CON group, P/A ratio was directly correlated with the protein thiols level (r = 0.495, p < 0.001). These data confirm the antioxidant action of tested cysteine derivatives, particularly lipoic acid, and demonstrate the practical application of P/A ratio to evaluate the effectiveness of antioxidants in athletes.Key words: oxidative stress, N-acetylcysteine, α-lipoic acid, taurine, athletes.Exhaustive eccentric or isometric exercises cause reactive oxygen species (ROS) generation and antioxidant depletion, and consequently the shift in pro-antioxidant equilibrium toward the peroxidation that can lead to negative changes in cell metabolism. These changes include the inhibition of enzymes and membrane receptor activities, the release of proinflammatory cytokines, an increase in Ca 2+ concentration, and an activation of proteases and nucleases, as well as structural cell damage [1].The intervention consisting in the weakening of ROS generation by antioxidant supplementation may prevent the adverse effects of exercise. Nevertheless, as shown in several studies the use of antioxidant vitamins hindered muscle repair after exercise, whereas the additional intake of sulfur-containing compounds could increase the defense against ROS [2,3].N-Acetylcysteine (NAC) is probably the most effective thiol compound. The studies showed that oral, intravenous or intraperitonal supplementation of NAC prevented a decline in muscle, lung, and blood thiols level and weakened exercise-induced glutathione oxidation. Besides the stimulation of glutathione synthesis, NAC also reduced extracellular cystine to cysteine, directly affec...

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Section: Discussionmentioning

confidence: 99%

“…The application of Loverro's coefficient [18] enables not only an analysis of pro-antioxidant equilibrium, but also an evaluation of antioxidant effectiveness in athletes.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Cysteine Derivatives Administration in Healthy Men Exposed to Intense Resistance Exercise by Evaluation of Pro-Antioxidant Ratio

2007

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“…Therefore uncontrolled lipid peroxidation in pregnancy has become very important in preeclampsia and its complications [27][28][29]. For these reasons, monitoring lipid peroxidation levels is an important tool for evaluating fetal stress.…”

Section: Discussionmentioning

confidence: 99%

Lipid Peroxidation and Antioxidant Status in Maternal and Cord Blood

Arikan

Konukoğlu

Arıkan

et al. 2001

Gynecol Obstet Invest

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The present study was undertaken to determine the change of blood lipid peroxide and antioxidant status in healthy nonpregnant women (n = 20), pregnant women in the third trimester (n = 20), pregnant women during delivery (n = 26) and fetal cord blood. Plasma and erythrocyte malondialdehyde (MDA) levels were found to be significantly higher and erythrocyte glutathione (GSH) levels were significantly lower in pregnant women in the third trimester than in nonpregnant women (p < 0.02, p < 0.03 and p < 0.001, respectively). The highest plasma and erythrocyte MDA levels and the lowest GSH levels were obtained from the pregnant women during delivery (6.99 ± 2.35 nmol/ml, 283.20 ± 43.81 nmol/g Hb, 6.73 ± 2.34 µmol/g Hb, respectively). Erythrocyte glutathione peroxidase (GSH-P) and glutathione reductase (GSH-R) activities were not different between the groups. Maternal plasma and erythrocyte MDA levels were significantly correlated with cord blood plasma and erythrocyte MDA levels (r = 0.63, p < 0.001, and r = 0.41, p < 0.001, respectively). There was a significant positive correlation in GSH-R and in GSH-P activities between maternal and cord blood erythrocytes (r = 0.81, p < 0.001, and r = 0.79, p < 0.001, respectively). A significant correlation was found between maternal erythrocyte GSH-P and both cord blood erythrocyte GSH-R activities (r = 0.74, p < 0.001) and cord erythrocyte GSH levels (r = 0.73, p < 0.001). There was also a significant negative correlation between maternal erythrocyte MDA and cord erythrocyte GSH-R levels (r = –0.9, p < 0.001). Our results suggest that lipid peroxidation and antioxidant status may be changed during delivery, and these changes may affect the fetus by creating oxidative stress.

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“…In preeclampsia, lipid peroxide levels are elevated, which is associated with a decreased antioxidant defense, such as catalase, glutathione peroxidase, and superoxide dismutase activity. 56,57 Interestingly, although acute exercise has been shown to promote oxidative stress, ExT stimulates antioxidant defenses (Figure). For instance, superoxide dismutase and glutathione peroxidase in skeletal muscle, plasma, and liver have been shown to be increased with ExT.…”

Section: Oxidative Stressmentioning

confidence: 99%

Impact of Exercise Training on Preeclampsia

et al. 2012

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Abstract-Preeclampsia is characterized by hypertension and de novo proteinuria after 20 weeks of pregnancy. It is the leading cause of perinatal morbidity and mortality in the developed world, and to date, the only means of treating the disease is by inducing delivery. Many studies have shown the benefits of exercise training on normal pregnancy. Conversely, because the impact of exercise on reducing the risk of preeclampsia has long been debated, the American College of Obstetricians and Gynecologists has yet to support the prescription of exercise training to women at risk of developing the disease. There is, however, a significant body of evidence in support of the protective role of exercise training against preeclampsia. A recent animal study demonstrated that many preeclampsia features can be eliminated with prenatal followed by gestational exercise training. Hence, the present article reviews the literature on the impact of exercise training on preeclampsia risk, as well as the mechanisms that may be involved.

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Lipoperoxidation and antioxidant enzymes activity in pregnancy complicated with hypertension

Cited by 65 publications

References 17 publications

Effect of Cysteine Derivatives Administration in Healthy Men Exposed to Intense Resistance Exercise by Evaluation of Pro-Antioxidant Ratio

Effect of Cysteine Derivatives Administration in Healthy Men Exposed to Intense Resistance Exercise by Evaluation of Pro-Antioxidant Ratio

Lipid Peroxidation and Antioxidant Status in Maternal and Cord Blood

Impact of Exercise Training on Preeclampsia

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