Lipophagy and Lipolysis Status in Lipid Storage and Lipid Metabolism Diseases

Kłoska, Anna; Węsierska, Magdalena; Malinowska, Marcelina; Gabig-Cimińska, Magdalena; Jakóbkiewicz‐Banecka, Joanna

doi:10.3390/ijms21176113

Cited by 62 publications

(44 citation statements)

References 193 publications

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“…Neutral lipolysis is the process in which cytoplasmic lipases such as the key cytoplasmic lipase, adipose triglyceride lipase (ATGL), and hormone-sensitive lipase (HSL) exert the hydrolytic effect by directly attaching to the surface of lipid droplets, and serving as another capital intracellular lipid degradation mode. Together with lipophagy, lipolysis constitutes the key to the regulation of lipid droplet catabolism ( Kloska et al, 2020 ). Studies have shown that lipase-driven decomposition of lipid droplets has proved part of its process depends on autophagy.…”

Section: The Function and Molecular Mechanism Of Tfeb Regulating Lipimentioning

confidence: 99%

TFEB: A Emerging Regulator in Lipid Homeostasis for Atherosclerosis

Wang

et al. 2021

Front. Physiol.

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Atherosclerosis, predominantly characterized by the disturbance of lipid homeostasis, has become the main causation of various cardiovascular diseases. Therefore, there is an urgent requirement to explore efficacious targets that act as lipid modulators for atherosclerosis. Transcription factor EB (TFEB), whose activity depends on post-translational modifications, such as phosphorylation, acetylation, SUMOylation, ubiquitination, etc., is significant for normal cell physiology. Recently, increasing evidence implicates a role of TFEB in lipid homeostasis, via its functionality of promoting lipid degradation and efflux through mediating lipophagy, lipolysis, and lipid metabolism-related genes. Furthermore, a regulatory effect on lipid transporters and lipid mediators by TFEB is emerging. Notably, TFEB makes a possible therapeutic target of atherosclerosis by regulating lipid metabolism. This review recapitulates the update and current advances on TFEB mediating lipid metabolism to focus on two intracellular activities: a) how cells perceive external stimuli and initiate transcription programs to modulate TFEB function, and b) how TFEB restores lipid homeostasis in the atherosclerotic process. In-depth research is warranted to develop potent agents against TFEB to alleviate or reverse the progression of atherosclerosis.

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Section: The Function and Molecular Mechanism Of Tfeb Regulating Lipimentioning

confidence: 99%

TFEB: A Emerging Regulator in Lipid Homeostasis for Atherosclerosis

Wang

et al. 2021

Front. Physiol.

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“…Lipid homeostasis is guaranteed by a delicate equilibrium among biosynthesis, uptake and catabolism. Kloska and colleagues [7] systematically reviewed the current knowledge on lipophagy and cytosolic lipolysis, two selective lipid catabolic processes whose activity is essential for the proper regulation of energy homeostasis in cells. The authors provide an in-depth discussion of the transcriptional modulation of these pathways by the mammalian target of rapamycin complex 1 (mTORC1) and by the transcription factor EB (TFEB).…”

mentioning

confidence: 99%

Facts about Fats: New Insights into the Role of Lipids in Metabolism, Disease and Therapy

Segatto

Pallottini

2020

IJMS

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“…Secondly, both pathways occur in multiple tissues and the products are same in supplying substrates for β-oxidation and cellular biosynthesis. 90 …”

Section: Discussionmentioning

confidence: 99%

“…Meanwhile, lipolysis is implemented step by step with different enzymes, such as ATGL, hormone-sensitive lipase and monoglyceride lipase. 90 Lipophagy forms autophagosomes to wrap LDs and deliver them to lysosome for degradation. Additionally, cross-talk of lipolysis and lipophagy exists.…”

Section: Discussionmentioning

confidence: 99%

Lipophagy: A New Perspective of Natural Products in Type 2 Diabetes Mellitus Treatment

Huang¹,

Yang²,

Wang³

et al. 2021

DMSO

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Autophagy has been reported to involve in the pathogenesis of type 2 diabetes mellitus (T2DM), which protects the insulin target tissues and pancreatic β-cells. However, autophagy is inhibited when the cells are lipid overload. That, in turn, increases the accumulation of fat. Lipotoxicity caused by excessive lipid accumulation contributes to pathogenesis of T2DM. Therefore, it is undeniable to break the vicious circles between lipid excess and autophagy deficiency. Lipophagy, a selective form of autophagy, is characterized by selective breakdown of lipid droplets (LDs). The nutritional status of cells contributes to the way of autophagy (selective or non-selective), while selective autophagy helps to accurately remove excess substances. It seems that lipophagy could be an effective means to decrease abnormal lipid accumulation that leads to insulin resistance and β-cell impairment by removing ectopic LDs. Based on this process, many natural compounds have been reported to decrease lipid accumulation in tissues through autophagy-lysosomal pathway, which gradually highlights the significance of lipophagy. In this review, we focus on the mechanisms that lipophagy improves T2DM and natural products that are applied to induce lipophagy. It is also suggested that natural herbs with rich contents of natural products inducing lipophagy would be potential candidates for alleviating T2DM.

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Lipophagy and Lipolysis Status in Lipid Storage and Lipid Metabolism Diseases

Cited by 62 publications

References 193 publications

TFEB: A Emerging Regulator in Lipid Homeostasis for Atherosclerosis

TFEB: A Emerging Regulator in Lipid Homeostasis for Atherosclerosis

Facts about Fats: New Insights into the Role of Lipids in Metabolism, Disease and Therapy

Lipophagy: A New Perspective of Natural Products in Type 2 Diabetes Mellitus Treatment

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