Lipophilic and Hydrophilic Compounds from Arthrospira platensis and Its Effects on Tissue and Blood Cells—An Overview

Jung, F.; Braune, S.; Jung, Conrad H. G.; Krüger‐Genge, Anne; Waldeck, Peter; Petrick, Ingolf; Küpper, Jan-Heiner

doi:10.3390/life12101497

Cited by 14 publications

(6 citation statements)

References 190 publications

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“…The content of vitamin E is comparable and sometimes higher than that in terrestrial plants [29]. The literature indicates a range of 5-20 mg/100 g [30]. In our case, it is 3.57 mg/100 g. This vitamin acts as an antioxidant, protecting membrane lipids from oxidation and damage [31].…”

Section: Resultssupporting

confidence: 46%

Metabolomic Profile of Arthrospira platensis from a Bulgarian Bioreactor—A Potential Opportunity for Inclusion in Dietary Supplements

Nikolova,

Gentscheva,

Gyurova

et al. 2024

Life

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The present study aims to elucidate the metabolomic profile of Arthrospira platensis grown in a bioreactor in Bulgaria. The results show that Arthrospira platensis has a high content of mannose, 137.02 mg g−1, and vitamin A (retinol)—10.3 μg/100 g. High concentrations of calcium, sulfur, and zinc distinguish its elemental composition. The freeze-dried powder contained 15.81 ± 0.45% dietary fiber, 50.16 ± 0.25% total protein content, and 1.22 ± 0.11% total fat content. Among the unsaturated fatty acids with the highest content is α-linolenic acid (25.28%), while among the saturated fatty acids, palmitic acid prevails (22.55%). Of the sterols in the sample, β-sitosterol predominated. There is no presence of microcystins LR, RR, YR, and nodularin. Therefore, Arthrospira platensis grown in a Bulgarian bioreactor is safe for use in the pharmaceutical and food industries. Many of the organic compounds found have applications in medicine and pharmacology and play an important role in biochemical processes in the body. Therefore, Arthrospira platensis grown in Bulgaria has a high potential for use as an independent food supplement or in combination with other natural products.

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Section: Resultssupporting

confidence: 46%

Metabolomic Profile of Arthrospira platensis from a Bulgarian Bioreactor—A Potential Opportunity for Inclusion in Dietary Supplements

Nikolova,

Gentscheva,

Gyurova

et al. 2024

Life

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“…The following supporting information can be downloaded at: https: //www.mdpi.com/article/10.3390/nu16111752/s1, Table S1: Effects of C-PC or PCB-B on different disease models [20,[24][25][26][27][28][29][30][31][32][33][34]36,[38][39][40][41][43][44][45][46][47][48][49][50][51][52][62][63][64][65][66][67][68]71,72,[76][77][78][79][80][81][82][85][86][87][88][90][91][92]...…”

Section: Supplementary Materialsmentioning

confidence: 99%

“…Their results reveal that the native C-PC was a powerful inhibitor (almost totally) at 1 μM, and it was more protective than recombinant Apo-C-PC. This protection was suggested to be due to the presence of cysteine residues on the protein surface, counteracting oxidation via thiol groups on the molecule [ 26 ].…”

Section: Health Promoting Effectsmentioning

confidence: 99%

“…The following supporting information can be downloaded at: , Table S1: Effects of C-PC or PCB-B on different disease models [ 20 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 36 , 38 , 39 , 40 , 41 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 71 , 72 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 85 , 86 , 87 , 88 , 90 , 91 , 92 , 93 , 94 , ...…”

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confidence: 99%

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Nutraceutical Features of the Phycobiliprotein C-Phycocyanin: Evidence from Arthrospira platensis (Spirulina)

Citi,

Torre,

Flori

et al. 2024

Nutrients

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Arthrospira platensis, commonly known as Spirulina, is a photosynthetic filamentous cyanobacterium (blue–green microalga) that has been utilized as a food source since ancient times. More recently, it has gained significant popularity as a dietary supplement due to its rich content of micro- and macro-nutrients. Of particular interest is a water soluble phycobiliprotein derived from Spirulina known as phycocyanin C (C-PC), which stands out as the most abundant protein in this cyanobacterium. C-PC is a fluorescent protein, with its chromophore represented by the tetrapyrrole molecule phycocyanobilin B (PCB-B). While C-PC is commonly employed in food for its coloring properties, it also serves as the molecular basis for numerous nutraceutical features associated with Spirulina. Indeed, the comprehensive C-PC, and to some extent, the isolated PCB-B, has been linked to various health-promoting effects. These benefits encompass conditions triggered by oxidative stress, inflammation, and other pathological conditions. The present review focuses on the bio-pharmacological properties of these molecules, positioning them as promising agents for potential new applications in the expanding nutraceutical market.

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“…Meanwhile, published articles on the effects of AdSP on cell behavior are mainly focused on the inhibition of tumor cell proliferation, anti-angiogenesis, enhancement of hematopoietic stem cells, etc. [ 12 , 13 , 14 ]. Only one study focuses on the effects of AdSP on the behavior of neural stem cells [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Cell Behavior by the Polysaccharide Extract of Arthrospira and Potential Biomedical Applications

Hsu

2023

Molecules

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Arthrospira is one of the most studied cyanobacteria and has been reported with practical applications. Among the substances derived from Arthrospira, polysaccharides have received relatively less attention than phycocyanins, though they have more abundant structural variations and specific properties. Herein, a new Arthrospira-derived sulfated polysaccharide was explored for its potential bioactive functions. The ability of this sulfated polysaccharide to promote the behavior of neural stem cells (NSCs) in three-dimensional hydrogel was examined for the first time. NSCs encapsulated in the sulfated polysaccharide-containing hydrogel showed better proliferation than the control hydrogel as well as a unique cell clustering behavior, i.e., formation of multicellular spherical clusters (40–60 μm). The sulfated polysaccharide, in an appropriate range of concentration (5 mg/mL), also maintained the stemness of NSCs in hydrogel and facilitated their differentiation. In addition, the potentials of the new sulfated polysaccharide as a coating material and as a component for drug carrier were verified. The sulfated polysaccharide-modified substrate exhibited superhydrophilicity (contact angle ~9) and promoted cell adhesion to the substrate. Composite nanoparticles composed of the sulfated polysaccharide and other differently charged polysaccharides were produced with an average diameter of ~240 nm and estimated drug loading of ~18%. The new Arthrospira-derived sulfated polysaccharide is a promising candidate for cell culture, surface-modification, and drug-delivery applications in the biomedical field.

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Lipophilic and Hydrophilic Compounds from Arthrospira platensis and Its Effects on Tissue and Blood Cells—An Overview

Cited by 14 publications

References 190 publications

Metabolomic Profile of Arthrospira platensis from a Bulgarian Bioreactor—A Potential Opportunity for Inclusion in Dietary Supplements

Metabolomic Profile of Arthrospira platensis from a Bulgarian Bioreactor—A Potential Opportunity for Inclusion in Dietary Supplements

Nutraceutical Features of the Phycobiliprotein C-Phycocyanin: Evidence from Arthrospira platensis (Spirulina)

Enhancement of Cell Behavior by the Polysaccharide Extract of Arthrospira and Potential Biomedical Applications

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