Lipophilic fluorescent products of free radicals

Ivica, J.; Wilhelm, J.

doi:10.5507/bp.2012.112

Cited by 13 publications

(4 citation statements)

References 84 publications

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“…Lipophilic fluorescent end-CL-products of free radicals may be an interesting marker [84]. Oxidative stress is also evaluated by tert-butyl hydroperoxide-initiated chemiluminescence [85] or the formation of ROS from 2′,7′-dichlorodihydrofluorescein-diacetate fluorescence [86].…”

Section: The Importance Of Os In Msmentioning

confidence: 99%

New Insights into the Role of Oxidative Stress Mechanisms in the Pathophysiology and Treatment of Multiple Sclerosis

Adamczyk

Adamczyk-Sowa

2016

Oxidative Medicine and Cellular Longevity

121

100

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Multiple sclerosis (MS) is a multifactorial disease of the central nervous system (CNS) characterized by an inflammatory process and demyelination. The etiology of the disease is still not fully understood. Therefore, finding new etiological factors is of such crucial importance. It is suspected that the development of MS may be affected by oxidative stress (OS). In the acute phase OS initiates inflammatory processes and in the chronic phase it sustains neurodegeneration. Redox processes in MS are associated with mitochondrial dysfunction, dysregulation of axonal bioenergetics, iron accumulation in the brain, impaired oxidant/antioxidant balance, and OS memory. The present paper is a review of the current literature about the role of OS in MS and it focuses on all major aspects. The article explains the mechanisms of OS, reports unique biomarkers with regard to their clinical significance, and presents a poorly understood relationship between OS and neurodegeneration. It also provides novel methods of treatment, including the use of antioxidants and the role of antioxidants in neuroprotection. Furthermore, adding new drugs in the treatment of relapse may be useful. The article considers the significance of OS in the current treatment of MS patients.

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Section: The Importance Of Os In Msmentioning

confidence: 99%

New Insights into the Role of Oxidative Stress Mechanisms in the Pathophysiology and Treatment of Multiple Sclerosis

Adamczyk

Adamczyk-Sowa

2016

Oxidative Medicine and Cellular Longevity

121

100

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“…Fluorescent oxidation products (FlOP) are a global marker of oxidative stress. Compared to commonly used oxidative stress biomarkers that reflect oxidative damage to specific cellular components, experimental studies demonstrated that reactive oxygen species, such as aldehydes or hydroperoxides, interact with subcellular components—including amino groups, fatty acids and DNA—to increase the formation of fluorescent products [ 23 , 24 , 25 , 26 ]. Thus, higher FlOP concentrations reflect higher levels of oxidative stress that arises from multiple cellular components.…”

Section: Introductionmentioning

confidence: 99%

Healthy Dietary Patterns and Oxidative Stress as Measured by Fluorescent Oxidation Products in Nurses’ Health Study

et al. 2016

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Healthy diets may lower oxidative stress and risk of chronic diseases. However, no previous studies examined associations between diet and fluorescent oxidation products (FlOP), a global marker of oxidative stress. We evaluated associations between healthy eating patterns (Alternative Healthy Eating Index (AHEI), Dietary Approach to Stop Hypertension (DASH), and Alternate Mediterranean Diet (aMED)) and FlOP, measured at three excitation/emission wavelengths (FlOP_360, FlOP_320, FlOP_400) from 2021 blood samples collected from 1688 women within the Nurses’ Health Study. AHEI, DASH, and aMED scores were significantly positively associated with FlOP_360 and FlOP_320 concentrations (p-trend ≤ 0.04), but not associated with FlOP_400. Among specific food groups that contribute to these diet scores, significantly positive associations were observed with legumes and vegetables for FlOP_360, vegetables and fruits for FlOP_320, and legumes and alcohol for FlOP_400. Inverse associations were observed with nuts, sweets or desserts, and olive oil for FlOP_360, nuts for FlOP_320 and sweets or desserts for FlOP_400 (all p-trend ≤ 0.05). However, FlOP variation due to diet was small compared to overall FlOP variation. In conclusion, AHEI, DASH, and aMED scores were unexpectedly positively, but weakly, associated with FlOP_360 and FlOP_320. However, these findings should be interpreted cautiously as the determinants of FlOP concentrations are not fully understood.

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“…This reaction results in the formation of intermediary products that continue to damage biological materials and finally results in chloroform-extractable lipophilic end products that contain innate fluorescent pigments ( Ayala et al, 2014 ). These fluorescent compounds (FC) have not been fully chemically defined but are widely used as markers of lipid oxidation ( Ivica and Wilhelm, 2014 ). In addition, when polyunsaturated fatty acids are oxidized, rearrangements of double bonds lead to the formation of membrane-conjugated dienes (CD) that are also a marker of lipid peroxidation ( Kodali et al, 2020 ).…”

Section: Methodsmentioning

confidence: 99%

Hypercapnia Causes Injury of the Cerebral Cortex and Cognitive Deficits in Newborn Piglets

Fritz,

Sanidas,

Cardenas

et al. 2024

eNeuro

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In critically ill newborns, exposure to hypercapnia (HC) is common and often accepted in neonatal intensive care units (NICUs) to prevent severe lung injury. However, as a “safe” range of arterial partial pressure of carbon dioxide (PaCO2) levels in neonates has not been established, the potential impact of HC on the neurodevelopmental outcomes in these newborns remains a matter of concern. Here, in a newborn Yorkshire piglet model of either sex, we show that acute exposure to HC induced persistent cortical neuronal injury, associated cognitive and learning deficits, and long-term suppression of cortical electroencephalographic (EEG) frequencies. HC induced a transient energy failure in cortical neurons, a persistent dysregulation of calcium-dependent pro-apoptotic signaling in the cerebral cortex, and activation of the apoptotic cascade, leading to nuclear deoxyribonucleic acid (DNA) fragmentation. While neither one hour of HC nor the rapid normalization of HC were associated with changes in cortical bioenergetics, rapid resuscitation resulted in a delayed onset of synaptosomal membrane lipid peroxidation, suggesting a dissociation between energy failure and the occurrence of synaptosomal lipid peroxidation. Even short durations of HC triggered biochemical responses at the subcellular level of the cortical neurons resulting in altered cortical activity and impaired neurobehavior. The deleterious effects of HC on the developing brain should be carefully considered as crucial elements of clinical decisions in the neonatal intensive care unit.Significance StatementHospitalized critically ill neonates commonly experience hypercapnia as part of common practice in neonatal intensive care, as ventilated newborns are subjected to "permissive hypercapnia" to reduce lung injury associated with positive pressure ventilation. To answer the clinically important question of how "safe" that practice is, the present study provides new insights into the complex effects of hypercapnia on neuronal processes, with significant ramifications for ongoing neurodevelopment.

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Lipophilic fluorescent products of free radicals

Cited by 13 publications

References 84 publications

New Insights into the Role of Oxidative Stress Mechanisms in the Pathophysiology and Treatment of Multiple Sclerosis

New Insights into the Role of Oxidative Stress Mechanisms in the Pathophysiology and Treatment of Multiple Sclerosis

Healthy Dietary Patterns and Oxidative Stress as Measured by Fluorescent Oxidation Products in Nurses’ Health Study

Hypercapnia Causes Injury of the Cerebral Cortex and Cognitive Deficits in Newborn Piglets

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