Lipophilic modification of salirasib modulates the antiproliferative and antimigratory activity

Ballari, María Sol; Porta, Exequiel O. J.; Zalazar, Evelyn Arel; Etichetti, Carla M. Borini; Padrón, José M.; Girardini, Javier E.; Labadié, Guillermo R.

doi:10.1016/j.bmc.2023.117417

Cited by 1 publication

(1 citation statement)

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“…Despite numerous years of research in this field, scientists in medicinal chemistry continue to pursue optimal derivatives through trial and error [178]. The utilization of experimental methods [179] or computational approaches [180] to determine the ideal lipophilicity of the designed active substance remains a distant prospect.…”

Section: Discussionmentioning

confidence: 99%

Advances in the Synthesis of Biologically Active Quaternary Ammonium Compounds

Fedorowicz,

Sączewski

2024

IJMS

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This review provides a comprehensive overview of recent advancements in the design and synthesis of biologically active quaternary ammonium compounds (QACs). The covered scope extends beyond commonly reviewed antimicrobial derivatives to include synthetic agents with antifungal, anticancer, and antiviral properties. Additionally, this review highlights examples of quaternary ammonium compounds exhibiting activity against protozoa and herbicidal effects, as well as analgesic and anesthetic derivatives. The article also embraces the quaternary-ammonium-containing cholinesterase inhibitors and muscle relaxants. QACs, marked by their inherent permanent charge, also find widespread usage across diverse domains such as fabric softeners, hair conditioners, detergents, and disinfectants. The effectiveness of QACs hinges greatly on finding the right equilibrium between hydrophilicity and lipophilicity. The ideal length of the alkyl chain varies according to the unique structure of each QAC and its biological settings. It is expected that this review will provide comprehensive data for medicinal and industrial chemists to design and develop novel QAC-based products.

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Section: Discussionmentioning

confidence: 99%