Lipopolysaccharide and Liposome-Encapsulated MTP-PE- Induced Cytotoxicity and Release of Eicosanoids, Tumor Necrosis Factor- α and Nitric Oxide in Liver Macrophages

Dieter, Peter; Ambs, Petra; Fitzke, Edith; Schwende, H.

doi:10.1007/978-1-4899-1813-0_72

Cited by 4 publications

(6 citation statements)

References 12 publications

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“…Dieter et al (1997) observed an induction of cytotoxicity of liver macrophages against tumor cells after stimulation with L-MTP-PE. In addition, Xu and Fidler (1984) recorded increased tumoricidal activity of Kupffer cells in mice after application of L-MTP-PE.…”

Section: Discussionmentioning

confidence: 86%

“…Kuppfer cells (liver macrophages) residing in the sinusoids of the liver appear to be target cells for the biological effect of MTP-PE (Dieter et al 1999). Macrophages activated by liposomized MTP-PE stimulate Th1 subpopulation of lymphocytes and pro-inflammatory mediators via cytokine secretion (Hsieh et al 1993;Asano et al 1994;Dieter et al 1997;ten Hagen et al 1998). T lymphocytes therefore constitute an active component of immune reactions after immunomodulation with muramylpeptides.…”

Section: Discussionmentioning

confidence: 99%

“…Muramyltripeptide phosphatidylethanolamine (MTP-PE) is a lipophilic derivate of MDP. Liposome-encapsulated MTP-PE has an enhanced effect on macrophages to secrete pro-inflammatory cytokines that results in the increase of cytotoxicity of these cells (Dieter et al 1997;Asano et al 1994;Melissen et al 1993a).…”

Section: Introductionmentioning

confidence: 99%

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Imunomodulative effect of liposomized muramyltripeptide phosphatidylethanolamine (L-MTP-PE) on mice with alveolar echinococcosis and treated with albendazole

2008

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The effect of liposomized muramyltripeptide phosphatidylethanolamine (L-MTP-PE) administered separately or with anthelmintic albendazole (ABZ) on cellular immunity of mice with alveolar echinococcosis was studied. The proliferative activity of splenic T and B lymphocytes was the most stimulated after combined L-MTP-PE + ABZ therapy [from weeks 8 to 14 post-infection (p.i.)] that also induced a long-term development of protective Th1 response (the highest serum concentration of IFN-gamma from weeks 8 to 18 p.i.). On the contrary, Th2 response (cytokine IL-5) in infected mice treated with L-MTP-PE was inhibited since week 8 p.i., but a significant long-term decrease in IL-5 concentration was found after combined L-MTP-PE+ABZ therapy until the end of the experiment (until week 26 p.i.). L-MTP-PE stimulated the production of superoxide anion (O2-) by peritoneal macrophages from weeks 8 to 12 p.i., but the highest O2- production was accordingly recorded after therapy L-MTP-PE+ABZ from weeks 8 to 18 p.i. Stimulation of cellular immunity of mice with alveolar echinococcis with L-MTP-PE and an interaction with ABZ's anti-parasitic effect resulted in the greatest and long-term reduction of growth of Echinococcus multilocularis cysts in the host from week 10 p.i. until the end of the experiment.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

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Imunomodulative effect of liposomized muramyltripeptide phosphatidylethanolamine (L-MTP-PE) on mice with alveolar echinococcosis and treated with albendazole

2008

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“…Muramyltripeptide phosphatidylethanolamine (MTP-PE) is a lipofilic derivate of MDP. Liposome-encapsulated MTP-PE has an enhanced effect on macrophages to secrete pro-inflammatory cytokines, which results in increasing of cytotoxicity of these cells [28][29][30].…”

Section: Muramyltripeptidementioning

confidence: 99%

“…The biological effect of MTP-PE takes place in Kuppfer cells in the liver (macrophage's equivalent) [32]. Macrophages activated by liposomized MTP-PE stimulate Th1 subpopulation of lymphocytes and proinflammatory mediators via cytokine secretion [28,29,33,34]. T lymphocytes therefore constitute an active component of immune reactions after immunomodulation with muramylpeptides.…”

Section: Muramyltripeptidementioning

confidence: 99%

Immunotherapy Can Enhance Anthelmintic Efficacy in Alveolar Echinococcosis

Dvorožnáková

2015

Current Topics in Echinococcosis

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The immune response of the intermediate host with alveolar echinococcosis was investigated on mice intraperitoneally infected with Echinococcus multilocularis protoscoleces. The study was focused on cell-mediated immune response (dependent on interactions of T lymphocytes and macrophages), which is considered protective in alveolar echinococcosis. The immune response to E. multilocularis is regulated by Th1/Th2 cytokines produced by the CD4+ T lymphocyte subpopulation. Metacestode has been known for its ability to modify immune functions and suppress effective specific cell response to ensure its survival in host organism. The influence of immunomodulatory substances -muramyltripeptide (L-MTP-PE), glucan (GI), glucan with zinc (GIZn), and transfer factor (TF) -applied alone or combined with anthelmintic albendazole (ABZ) on regulative and effector components of immunity were tested and at the same time, antiparasitic efficacy of immunomodulators was evaluated.

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Sensitization by interleukin-6 of rat hepatocytes to tumor necrosis factor α-induced apoptosis

Böer

Fennekohl

Püschel

2003

Journal of Hepatology

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Lipopolysaccharide and Liposome-Encapsulated MTP-PE- Induced Cytotoxicity and Release of Eicosanoids, Tumor Necrosis Factor- α and Nitric Oxide in Liver Macrophages

Cited by 4 publications

References 12 publications

Imunomodulative effect of liposomized muramyltripeptide phosphatidylethanolamine (L-MTP-PE) on mice with alveolar echinococcosis and treated with albendazole

Imunomodulative effect of liposomized muramyltripeptide phosphatidylethanolamine (L-MTP-PE) on mice with alveolar echinococcosis and treated with albendazole

Immunotherapy Can Enhance Anthelmintic Efficacy in Alveolar Echinococcosis

Sensitization by interleukin-6 of rat hepatocytes to tumor necrosis factor α-induced apoptosis

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