Lipopolysaccharide-binding protein and presepsin in patients with SARS-CoV-2 viral lung disease in the Republic of Crimea

Yatskov, I. A.; Белоглазов, В. А.; Kubyshkin, Anatoly V.; Nikolaeva, A. P.; Zyablitskaya, Evgeniya Y.; Kunitskaya, Ju. E.; Lavrenchuk, N. E.

doi:10.18093/0869-0189-2022-32-2-162-170

Pulʹmonologiâ (Mosk.)

2022

DOI: 10.18093/0869-0189-2022-32-2-162-170

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Lipopolysaccharide-binding protein and presepsin in patients with SARS-CoV-2 viral lung disease in the Republic of Crimea

I. A. Yatskov¹,

В. А. Белоглазов²,

Anatoly V. Kubyshkin³

et al.

Abstract: Although more than 2 years have passed since the beginning of the pandemic of the new coronavirus infection, treatment and prediction of the course of SARS-CoV-2 infection remain pressing global problems. In this regard, the search for additional links in the pathogenesis of SARS-CoV-2 is currently one of the most important tasks. The Aim. To assess the level of lipopolysaccharide-binding protein (LBP) and presepsin (sCD14-ST) in patients with SARS-CoV-2 viral lung disease in Crimea.Methods. We examined 121 pa… Show more

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Cited by 2 publications

References 37 publications

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Role of Toll-like receptor gene polymorphism in pathogenesis of new coronavirus infection

Beloglazov,

Yatskov,

Kamshiy

et al. 2023

Med. immunol.

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The review article contains data from literature which concern the role of Toll-like receptors (TLRs), immune sensors that play a key role in the systemic response to both bacterial and viral infections, e.g., in pathogenesis of a new coronavirus infection (COVID-19, SARS-CoV-2 infection). With advent of COVID-19, which has reached the scale of a pandemic, the interest in studying predictive factors for the severity of the infectious process has acquired a new cycle. The previous epidemics caused by severe acute respiratory syndrome virus (SARS-CoV), as well as the Middle East respiratory syndrome coronavirus (MERS-CoV), helped us to understand the degree of immune response in these conditions, as well as to suggest medical approaches to the pathogens of this family, i.e., which measures should be taken, and what long-term forecasts may be encountered for the SARS-CoV-2 outbreaks. Each of the 10 human TLRs recognizes a specific structure within a bacterial / viral or fungal pathogen. The effect on TLR activates the inflammatory signaling cascade via mediators, i.e., intracellular TIR domains mediated by adapter proteins. These reactions lead to the production of the most important antiviral response substances. The factors that lead to reduced / increased expression of TLR genes include gene polymorphisms which control the functioning of the immune system in some ways, thus causing a reduced, or hyperinflammatory response to an infectious agent. Genetic heterogeneity is likely to explain, at least partially, the wide range of clinical manifestations of COVID-19 infection in general population. Therefore, there is an increased interest in studies of these receptors, the degree of their expression throughout the infectious process, the polymorphisms of the TLR-encoding genes, and, consequently, the opportunity of using clinical and laboratory tests for their qualitative and quantitative assessment, as well as selection and prospects of further treatment in each personal case.

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Role of Toll-like receptor gene polymorphism in pathogenesis of new coronavirus infection

Beloglazov,

Yatskov,

Kamshiy

et al. 2023

Med. immunol.

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Low-grade systemic inflammation in patients with long COVID: The role of imbalance of endotoxin-releasing systems and vasoconstrictor markers

Beloglazov,

Dudchenko,

Useinova

et al. 2024

Acta biomedica scientifica

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Background. Currently, the pathophysiological mechanisms of acute damage to organs and systems caused by coronavirus infection have been studied quite fully, but the mechanisms underlying the clinical manifestations of long COVID have not yet been accurately described. The mechanisms of persistence of a number of symptoms in patients who have had COVID-19 and the role of systemic inflammation and endotoxemia markers in it remain a understudied aspect and a promising direction for further studying.The aim of the study. To assess the markers of systemic inflammation, endotoxin-releasing systems, intestinal permeability and endothelial dysfunction in patients with long COVID at the stage of health resort treatment.Methods. The study included 32 patients who had recovered from coronavirus infection and were undergoing health resort treatment in the pulmonology department of the I.M. Sechenov Academic Research Institute for Physical Therapy, Medical Climatology and Rehabilitation. We also selected a control group (n = 20). All patients underwent peripheral blood analysis to detect the levels of markers of systemic inflammation, endotoxin-releasing systems, intestinal permeability, endothelial dysfunction and vasoconstrictor agents: C-reactive protein (CRP), lipopolysaccharide-binding protein (LPB), tissue-type plasminogen activator (tPA), zonulin, bactericidal/ permeability-increasing protein (BPI), vasopressors of angiotensin 2 and endothelin (EDN1).Results. Patients who had recovered from coronavirus infection had a statistically significant increase in the levels of CRP (3.4 [2.56; 4.0] mg/l), LBP (18.46 [14.0; 25.5] ng/ml), tPA (0.07 [0.02; 0.32] ng/ml), angiotensin 2 (133.3 [63.0; 503.7] pg/ml) and a decrease in the level of BPI (1576 [276; 3588] pg/ml) (p < 0.05).Conclusion. A statistically significant increase in markers of systemic inflammation, endotoxinemia, and vasoconstrictor agents in patients with long COVID indicates an imbalance in endotoxin-binding and endotoxin-releasing systems in patients who have had coronavirus infection. Further study of the described markers is necessary to improve approaches to long-term personalized therapy for this category of patients.

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Lipopolysaccharide-binding protein and presepsin in patients with SARS-CoV-2 viral lung disease in the Republic of Crimea

Cited by 2 publications

References 37 publications

Role of Toll-like receptor gene polymorphism in pathogenesis of new coronavirus infection

Role of Toll-like receptor gene polymorphism in pathogenesis of new coronavirus infection

Low-grade systemic inflammation in patients with long COVID: The role of imbalance of endotoxin-releasing systems and vasoconstrictor markers

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