2019
DOI: 10.1002/eji.201847910
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Lipopolysaccharide impacts murine CD103+ DC differentiation, altering the lung DC population balance

Abstract: Conventional DCs are a heterogeneous population that bridge the innate and adaptive immune systems. The lung DC population comprises CD103+XCR1+ DC1s and CD11b+ DC2s; their various combined functions cover the whole spectrum of immune responses needed to maintain homeostasis. Here, we report that in vivo exposure to LPS leads to profound alterations in the proportions of CD103+XCR1+ DCs in the lung. Using ex vivo LPS and TNF stimulations of murine lung and spleen‐isolated DCs, we show that this is partly due t… Show more

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Cited by 4 publications
(23 citation statements)
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“…Also, a higher migratory rate of cDC1s from the lung to the draining lymph nodes could take part in the observed decrease percentage of this population following P. aeruginosa exposure (Ho et al, 2011;Nakano et al, 2013). Supported by previously-published results (Brassard et al, 2019) and present data, we propose that under homeostatic conditions, newly-recruited lung pre-DCs acquire CD103 expression in response to GM-CSF stimulation through their final differentiation into cDCs. However, in the context of Gramnegative bacterial exposure, the interaction with the bacteria or LPS prevents CD103 mRNA synthesis resulting in lower GM-CSF-induced CD103 expression on cDC1s.…”
Section: Discussionsupporting
confidence: 84%
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“…Also, a higher migratory rate of cDC1s from the lung to the draining lymph nodes could take part in the observed decrease percentage of this population following P. aeruginosa exposure (Ho et al, 2011;Nakano et al, 2013). Supported by previously-published results (Brassard et al, 2019) and present data, we propose that under homeostatic conditions, newly-recruited lung pre-DCs acquire CD103 expression in response to GM-CSF stimulation through their final differentiation into cDCs. However, in the context of Gramnegative bacterial exposure, the interaction with the bacteria or LPS prevents CD103 mRNA synthesis resulting in lower GM-CSF-induced CD103 expression on cDC1s.…”
Section: Discussionsupporting
confidence: 84%
“…We also report a decrease in CD103 + XCR1 + cDC1 proportions and, in return, an increase in CD11b + Sirpa + cDC2 proportions (Figure 1C). These results indicate that, as observed previously with LPS (Brassard et al, 2019), P. aeruginosa modulates lung cDC populations in favor of the DC2/monocyte-derived DC population.…”
Section: Lung Exposure To the Gram-negative Bacteria Pseudomonas Aeruginosa Leads To A Major Modulation Of DC Populationssupporting
confidence: 89%
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