Lipopolysaccharide-induced expression of inducible nitric oxide synthase in the guinea pig organ of Corti

Takumida, Masaya; Anniko, Matti; Popa, Raul; Zhang, De Ming

doi:10.1016/s0378-5955(99)00188-4

Cited by 46 publications

(30 citation statements)

References 38 publications

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“…21) Increased NO production from iNOS has been demonstrated in animals with hearing loss caused by drugs and loud sound stimulation. [22][23][24] Taken together with previous reports, our results suggest that excess NO under sildenafil treatment is toxic to auditory organs such as the cochlea and the auditory nerve.…”

supporting

confidence: 86%

High Dosage Sildenafil Induces Hearing Impairment in Mice

Hong

Kim

et al. 2008

Biological & Pharmaceutical Bulletin

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Sildenafil is widely administered for the treatment of erectile dysfunction. Recently, sensorineural hearing loss following the ingestion of sildenafil was reported in one male patient. We examined hearing in mice that were administered high doses of sildenafil for up to 105 d. To assess hearing impairment, we evaluated auditory brainstem responses, auditory middle latency responses, and otoacoustic emissions. At high doses, sildenafil increased the hearing threshold shift of auditory brainstem responses. High-dose sildenafil treatment also resulted in delayed latency of both auditory brainstem responses and auditory middle responses. Otoacoustic emissions differed between control and high-dose sildenafil groups with long-term treatment. Collectively, these data demonstrate that high-dose and long-term sildenafil administration can induce hearing impairment in mice.

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supporting

confidence: 86%

High Dosage Sildenafil Induces Hearing Impairment in Mice

Hong

Kim

et al. 2008

Biological & Pharmaceutical Bulletin

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“…These aforementioned alterations may be responsible or may happen together with NOS II expression, with NO production damaging hair cells and also the marginal cells of the stria vascularis and over activate the ON/GMPc via with consequent cochlear microcirculation dysfunction and greater glutamate release. The latter would block neural transmission through N-metil-D-aspartato receptors 2,7,8,10,29 . Aminoguanidine was probably capable of mitigating these lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Within this context we have nitric oxide (NO), participant in a number of physiological and physiopathological processes in various systems, in the inner ear it acts in neurotransmission and bears a regulating action on the vascular tonus and on homeostasis and endolymph 1,2 . NO is synthesized from L-arginine by a family of cytoplasm enzymes called nitric oxide synthetases (NOS).…”

Section: Introductionmentioning

confidence: 99%

“…NOS II has its production induced by different stimulus such as cytokines, ischemia, interferon or lipopolysaccharide, it is calcium-dependent, it is not usually expressed in the cochlea and produces NO in great amounts, about 100 to 1000 times more that NOS I and III 2,4,[5][6][7] . When produced in greater amounts and continuously, NO has neurotoxic and citotoxic effects, moreover, the former is catalyzed by NOS II 2,[7][8][9][10] . Studies in which NO donors are used, in other words, exogenous substances that release NO when metabolized, show that NO causes cell injury and loss of hair cells.…”

Section: Introductionmentioning

confidence: 99%

“…Studies in which NO donors are used, in other words, exogenous substances that release NO when metabolized, show that NO causes cell injury and loss of hair cells. Besides structural lesions, there are alterations in electrophysiological thresholds, endocochlear potential, auditory nerve action potential amplitude and cochlear microphone amplitude 2,11 . In a research carried out in guinea pigs with experimental endolymphatic hydrops secondary to endolymphatic sac and duct block, NOS II was detected in ganglionic cells, support cells, spiral ligament and stria vascularis.…”

Section: Introductionmentioning

confidence: 99%

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Hidropsia endolinfática experimental sob ação de inibidor da óxido nítrico sintase tipo II: avaliação com emissões otoacústicas e eletrococleografia

Ikino

Bittar²,

Sato

et al. 2006

Rev. Bras. Otorrinolaringol.

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No modelo experimental de hidropsia endolinfática há redução na amplitude das emissões otoacústicas produtos de distorção (EOAPD) e elevação nos limiares eletrofisiológicos na eletrococleografia. Estudos mostraram que há expressão da óxido nítrico sintase tipo II (ONS II) na cóclea com hidropsia, sugerindo a participação do óxido nítrico (ON) na patogênese desta doença. O objetivo deste trabalho foi avaliar a ação de um inibidor da ONS II nas EOAPD e eletrococleografia em cobaias com hidropisia endolinfática experimental. MATERIAL E MÉTODOS: Foram estudadas 16 cobaias nas quais se induziu hidropsia endolinfática experimental por obliteração do ducto e saco endolinfático na orelha direita durante 16 semanas, divididas em dois grupos: oito cobaias recebendo um inibidor da ONS II, a aminoguanidina, por via oral e um grupo de oito cobaias como controle. Comparamos as amplitudes das EOAPD nas médias geométricas de freqüências de 1062, 2187, 4375 e 7000Hz, os limiares eletrofisiológicos nas freqüências de 1000, 2000, 4000 e 6000Hz e a relação entre os potenciais de somação e de ação (PS/PA) entre os grupos. RESULTADOS: Não houve diferença significante nas EOAPD e na relação PS/PA entre os grupos. O grupo que recebeu a aminoguanidina apresentou menor elevação nos limiares eletrofisiológicos nas freqüências de 2000 (p<0,05) e 6000 Hz (p<0,05) na 12ª semana e nas freqüências de 1000 (p<0,05), 2000 (p<0,001), 4000 (p<0,001) e 6000Hz (p<0,001) na 16ª semana. CONCLUSÕES: O inibidor da ONS II reduziu a elevação dos limiares eletrofisiológicos na eletrococleografia na hidropsia endolinfática experimental.

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Phosphodiesterase Type 5 Inhibitor Use and Hearing Impairment

McGwin

2010

Arch Otolaryngol Head Neck Surg

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Lipopolysaccharide-induced expression of inducible nitric oxide synthase in the guinea pig organ of Corti

Cited by 46 publications

References 38 publications

High Dosage Sildenafil Induces Hearing Impairment in Mice

High Dosage Sildenafil Induces Hearing Impairment in Mice

Hidropsia endolinfática experimental sob ação de inibidor da óxido nítrico sintase tipo II: avaliação com emissões otoacústicas e eletrococleografia

Phosphodiesterase Type 5 Inhibitor Use and Hearing Impairment

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