Lipopolysaccharide-induced goblet cell hypersecretion in the guinea pig trachea: inhibition by macrolides

Tamaoki, J; Takamatsu, Kiyoshi; Yamawaki, Isao; Kondo, Mitsuko; Konno, K.

doi:10.1152/ajplung.1997.272.1.l15

Cited by 31 publications

(29 citation statements)

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“…In addition, the time to successful discontinuation of mechanical ventilation was shorter in participants given macrolides, compared with participants not receiving macrolides (adjusted hazard ratio [HR] for successful ventilator models suggest a therapeutic role for macrolide antibiotics in ALI. [14][15][16][17][18][19][20] We sought to investigate the association between macrolide antibiotics and mortality in patients with ALI using data from the Acute Respiratory Distress Syndrome Network (ARDSNet) Lisofylline and Respiratory Management of Acute Lung Injury (LARMA) trial. 8 We hypothesized that use of macrolide antibiotics would be associated with reduced mortality in patients with ALI.…”

Section: Resultsmentioning

confidence: 99%

“…the use of macrolide therapy in community-acquired pneumonia, 11 ventilator-associated pneumonia, 29 diffuse panbronchiolitis, 12 and cystic fi brosis. 13 Specifi cally, the pleiotropic antiinfl ammatory activities of macrolides include attenuation of pulmonary epithelial cell nuclear factor-k B activity, 30 decreased survival 31 and oxidative burst 32 of activated neutrophils, reduced endotoxin-induced goblet cell hypersecretion, 18 and inhibition of immune-complex-induced lung injury. 17 The potential therapeutic value of the antiinfl ammatory effects of macrolides is supported by observations in murine models of ALI caused by endotoxin, 16,19 infl uenza, 14 or bleomycin, 15,20 which have demonstrated less severe injury and increased survival with macrolide treatment.…”

Section: Discussionmentioning

confidence: 99%

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Macrolide Antibiotics and Survival in Patients With Acute Lung Injury

Walkey

Wiener

2012

Chest

101

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Macrolide Antibiotics and Survival in Patients With Acute Lung Injury

Walkey

Wiener

2012

Chest

101

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“…With regard to the effect of macrolide treatment on mucus secretion, previous studies reported that erythromycin inhibits respiratory glycoconjugate secretion from human airways in vitro (12) and reduced mucin secretion from cultured guinea pig epithelial cells (33). However, to our knowledge, there are no studies that have previously analyzed the effect of macrolides on mucin core proteins.…”

Section: Discussionmentioning

confidence: 99%

Clarithromycin inhibits overproduction of muc5ac core protein in murine model of diffuse panbronchiolitis

Kaneko

Yanagihara²,

Seki³

et al. 2003

American Journal of Physiology-Lung Cellular and Molecular Phys

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Long-term treatment of macrolide antibiotics is considered an effective treatment for diffuse panbronchiolitis (DPB). Although hypersecretion is a common feature of this disease, and it is known that macrolides inhibit mucin production, the mechanism of the effect on mucin production is unclear. The aim of our study was to determine the production of muc5ac core protein, a major core protein of mucin in airway secretion, and the effect of clarithromycin treatment on such production in a mouse model mimicking DPB. Alcian blue-periodic acid-Schiff-positive cells were detected in the lungs of Pseudomonas aeruginosa-infected mice. Western blots of these mice showed muc5ac glycoprotein at day 1 and increased progressively from day 4 to day 14 after inoculation of bacteria. Clarithromycin (10 mg · kg-1 · day-1 for 7 days) significantly reduced the muc5ac expression at both the mRNA and protein levels. To investigate the role of molecules upstream in muc5ac regulation, we examined the role of mitogen-activated protein kinase. Extracellular signal-regulated kinase 1/2 phosphorylation increased in the infected lung and decreased after treatment. Our results suggest that overproduction of muc5ac plays an important role in the pathogenesis of DPB and that clinical improvement following macrolide therapy seems to involve, at least in part, its inhibition of mucin overproduction, through modulation of intracellular signal transduction.

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“…Erythromycin was also reported to attenuate bronchial hyperresponsiveness in patients with bronchial asthma, probably through its inhibitory action on superoxide production and chemotaxis of neutrophils [32]. Erythromycin may also be helpful in asthma management, through protection of the ciliated airway epithelium from the action of bioactive phospholipids [33], reduction of mucus production [34] and improvement of the biophysical properties of mucus [35]. Finally, it has been suggested that erythromycin inhibits glucocorticoid clearance and enhances the effect of steroid therapy on asthma [36].…”

Section: Discussionmentioning

confidence: 99%

Treatment of chronic rhinosinusitis and its effects on asthma

Ragab

Scadding²,

Lund³

et al. 2006

Eur Respir J

145

100

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The effects of rhinosinusitis treatment upon asthma are disputed.The first randomised prospective study of surgical compared with medical therapy of chronic rhinosinusitis in 90 patients with and without nasal polyps was previously reported. Asthma symptoms, control, forced expiratory volume in one second (FEV1), peak flow, exhaled nitric oxide, medication use and hospitalisation at 6 and 12 months from the start of the study were also monitored. This paper reports these results in 43 of those patients with concomitant asthma.Both medical and surgical treatment of chronic rhinosinusitis were associated with subjective and objective improvements in asthma. Overall asthma control improved significantly following both treatment modalities, but was better maintained after medical therapy, where improvement could also be demonstrated in the subgroup with nasal polyps. Medicine was superior to surgery with respect to a decrease in exhaled nitric oxide and increase in FEV1 in the polyp patients. Two patients noted worsening of asthma post-operatively.Improvement in upper airway symptoms, as assessed using a visual analogue scale, correlated with improvement in asthma symptoms and control. Treatment of chronic rhinosinusitis, medical or surgical, benefits concomitant asthma; that associated with nasal polyposis benefits more from medical therapy.KEYWORDS: Asthma, chronic rhinosinusitis, endoscopic sinus surgery, exhaled nitric oxide, forced expiratory volume in one second, nasal polyps R hinosinusitis coexisted with asthma in 34% of patients in one study [1]. Radiological studies have shown abnormal sinus radiographs in 53% [2,3] and mucosal thickening on sinus computed tomography (CT) scans in 74% [4] of patients with asthma. Recently, .84% of CT scans were found to be abnormal in severe asthma, with a correlation between the extent of CT changes, sputum eosinophilia and pulmonary function [5].A number of authors have investigated the effect of surgical treatment of rhinosinusitis upon asthma, with improvement [6-8], worsening [9, 10] and equivocal effect [11,12] being reported. Only two studies of medical chronic rhinosinusitis (CRS) treatment exist, one included four medical patients [13], whereas the other considered CRS with polyposis alone and was nonrandomised [14]. MATERIALS AND METHODSPatients were recruited over 2 yrs from the Rhinology Clinics of the Royal National Throat, Nose and Ear Hospital (London, UK). The study was approved by the Ethics Committee of the Royal Free Hospital (London, UK). After application of exclusion criteria, the study was discussed with 327 consecutive patients with a primary diagnosis of CRS. Of these, 90 patients who agreed to the process of randomisation were finally included and were randomised equally into the medical and surgical groups. The study design and flow chart showing the course of the study are presented in figures 1 and 2, respectively. Diagnosis of CRS was based on the criteria described by the Staging and Therapy Group [15]. The criteria for diagnosis of...

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Lipopolysaccharide-induced goblet cell hypersecretion in the guinea pig trachea: inhibition by macrolides

Cited by 31 publications

References 0 publications

Macrolide Antibiotics and Survival in Patients With Acute Lung Injury

Macrolide Antibiotics and Survival in Patients With Acute Lung Injury

Clarithromycin inhibits overproduction of muc5ac core protein in murine model of diffuse panbronchiolitis

Treatment of chronic rhinosinusitis and its effects on asthma

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