2015
DOI: 10.1159/000441506
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Lipopolysaccharide Induces Chronic Kidney Injury and Fibrosis through Activation of mTOR Signaling in Macrophages

Abstract: Background: Septic kidney injury is one of the most common complications in critically ill patients with a high risk of developing chronic kidney disease (CKD). Emerging data indicate that mammalian target of rapamyci (mTOR) signaling plays a major role in septic inflammation by regulating the immune response of macrophage. This study was designed to evaluate the role of mTOR signaling in kidney macrophages during endotoxemia-induced chronic kidney injury and subsequent fibrogenesis. Methods: Male C57BL/6 mice… Show more

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Cited by 48 publications
(38 citation statements)
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“…Inflammation and fibrosis are featured events in the progress of CKD, regardless of the initial cause (6). Interstitial fibrosis is the common final outcome of progressive CKDs and results in irreversible renal damage.…”
Section: Discussionmentioning
confidence: 99%
“…Inflammation and fibrosis are featured events in the progress of CKD, regardless of the initial cause (6). Interstitial fibrosis is the common final outcome of progressive CKDs and results in irreversible renal damage.…”
Section: Discussionmentioning
confidence: 99%
“…Inappropriate mTORC1 activation in NAFLD and CKD inhibits autophagy (23,67) and promotes insulin resistance, ectopic lipid accumulation, lipotoxicity, and proinflammatory monocyte recruitment in the liver and kidney (Fig. 2B) (24,25). Consistently, mTORC1 inhibition has reversed metabolic abnormalities and attenuated lipid accumulation, inflammation, and fibrosis in diverse models of NASH and CKD (68,69) and may represent a therapeutic option for NAFLD and CKD (70) ( Table 2).…”
Section: Role Of Cellular Energy Oxygen and Nutrient Sensorsmentioning
confidence: 91%
“…The gut microbiome can shift markedly in CKD patients and uremic rats [7]. Gut microbiotaderived metabolites, such as ammonia [8,9], indoxyl sulfate, pcresyl sulfate [10], short-chain fatty acids [11,12], and lipopolysaccharides [13] may be associated with kidney injury and DM progression.…”
Section: Introductionmentioning
confidence: 99%