Lipopolysaccharide, VE-cadherin, HMGB1, and HIF-1α levels are elevated in the systemic circulation in chronic migraine patients with medication overuse headache: evidence of leaky gut and inflammation

Vuralli, Doga; Ceren Akgor, Merve; Gok Dagidir, Hale; Gulbahar, Ozlem; Yalinay, Meltem; Bolay, Hayrunnisa

doi:10.1186/s10194-024-01730-5

Cited by 6 publications

(1 citation statement)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The genus Bacteroides is reduced in a treatment-nonresponsive depressed subgroup compared to in healthy controls [78], and it has a rich arsenal for metabolizing more complex carbohydrates, including glycans of human mucin [166,167]. In agreement with this hypothesis, Vuralli et al [168] reported that an increased intestinal permeability, probably related to gut microbiota changes, would impact the response to anti-CGRP monoclonal antibodies in people with migraine. Figure 2 shows the microbiota-GBA crosstalk in migraine and depression.…”

Section: Potential Mechanisms Related To Microbiota and Relevant To T...mentioning

confidence: 86%

A Narrative Review of Intestinal Microbiota’s Impact on Migraine with Psychopathologies

Francavilla,

Facchetti,

Demartini

et al. 2024

IJMS

View full text Add to dashboard Cite

Migraine is a common and debilitating neurological disorder characterized by the recurrent attack of pulsating headaches typically localized on one side of the head associated with other disabling symptoms, such as nausea, increased sensitivity to light, sound and smell and mood changes. Various clinical factors, including the excessive use of migraine medication, inadequate acute treatment and stressful events, can contribute to the worsening of the condition, which may evolve to chronic migraine, that is, a headache present on >15 days/month for at least 3 months. Chronic migraine is frequently associated with various comorbidities, including anxiety and mood disorders, particularly depression, which complicate the prognosis, response to treatment and overall clinical outcomes. Emerging research indicates a connection between alterations in the composition of the gut microbiota and mental health conditions, particularly anxiety and depression, which are considered disorders of the gut–brain axis. This underscores the potential of modulating the gut microbiota as a new avenue for managing these conditions. In this context, it is interesting to investigate whether migraine, particularly in its chronic form, exhibits a dysbiosis profile similar to that observed in individuals with anxiety and depression. This could pave the way for interventions aimed at modulating the gut microbiota for treating difficult-to-manage migraines.

show abstract

Section: Potential Mechanisms Related To Microbiota and Relevant To T...mentioning

confidence: 86%

A Narrative Review of Intestinal Microbiota’s Impact on Migraine with Psychopathologies

Francavilla,

Facchetti,

Demartini

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

Dairy and Headaches: What is the Connection?

Ceren Akgör,

Ekizoğlu,

Özge

2024

Curr Pain Headache Rep

View full text Add to dashboard Cite

Purpose of Reviews Headaches represent a prevalent and burdensome health condition, affecting individuals of all ages worldwide. While dietary factors have been implicated in headache pathophysiology, the association between dairy consumption and headaches remains controversial and inadequately understood. This comprehensive review systematically examines the existing literature to elucidate the relationship between dairy intake and headaches, addressing methodological challenges, potential biases, and gaps in the current knowledge. Recent Findings A thorough search of electronic databases identified relevant observational studies, clinical trials, and mechanistic investigations exploring the impact of dairy consumption on headache incidence, frequency, severity, and duration. Methodological considerations, including study design, measurement of exposure and outcome variables, confounding factors, and sources of bias, were critically evaluated to assess the strength of evidence and validity of findings. Despite heterogeneity across studies, emerging evidence suggests a complex and multifaceted relationship between dairy intake and headaches, influenced by individual characteristics, dietary patterns, headache subtype, and study context. While some studies report a positive association between dairy consumption and headaches, others indicate no significant effect or potential therapeutic benefits of dairy restriction. Mechanistic insights suggest plausible biological mechanisms, including neuroinflammatory pathways, neurotransmitter modulation, vascular effects, and gut-brain interactions, which may mediate the observed associations. Summary Future research directions encompass longitudinal studies, mechanistic investigations, stratified analyses, randomized controlled trials, and exploration of the gut microbiota to further elucidate the underlying mechanisms and inform evidence-based dietary recommendations for headache management. This integrative review underscores the importance of interdisciplinary collaboration and personalized approaches to address the complex interplay between diet, headaches, and overall health.

show abstract

Pediatric migraine is characterized by traits of ecological and metabolic dysbiosis and inflammation

Papetti,

Del Chierico,

Frattale

et al. 2024

J Headache Pain

View full text Add to dashboard Cite

Background Recently, there has been increasing interest in the possible role of the gut microbiota (GM) in the onset of migraine. Our aim was to verify whether bacterial populations associated with intestinal dysbiosis are found in pediatric patients with migraine. We looked for which metabolic pathways, these bacteria were involved and whether they might be associated with gut inflammation and increased intestinal permeability. Methods Patients aged between 6 and 17 years were recruited. The GM profiling was performed by the 16S rRNA metataxonomics of faecal samples from 98 patients with migraine and 98 healthy subjects. Alpha and beta diversity analyses and multivariate and univariate analyses were applied to compare the gut microbiota profiles between the two group. To predict functional metabolic pathways, we used phylogenetic analysis of communities. The level of indican in urine was analyzed to investigate the presence of metabolic dysbiosis. To assess gut inflammation, increased intestinal permeability and the mucosal immune activation, we measured the plasmatic levels of lipopolysaccharide, occludin and IgA, respectively. Results The α-diversity analysis revealed a significant increase of bacterial richness in the migraine group. The β-diversity analysis showed significant differences between the two groups indicating gut dysbiosis in patients with migraine. Thirty-seven metabolic pathways were increased in the migraine group, which includes changes in tryptophan and phenylalanine metabolism. The presence of metabolic dysbiosis was confirmed by the increased level of indican in urine. Increased levels of plasmatic occludin and IgA indicated the presence of intestinal permeability and mucosal immune activation. The plasmatic LPS levels showed a low intestinal inflammation in patients with migraine. Conclusions Pediatric patients with migraine present GM profiles different from healthy subjects, associated with metabolic pathways important in migraine. Supplementary Information The online version contains supplementary material available at 10.1186/s10194-024-01871-7.

show abstract

Lipopolysaccharide, VE-cadherin, HMGB1, and HIF-1α levels are elevated in the systemic circulation in chronic migraine patients with medication overuse headache: evidence of leaky gut and inflammation

Cited by 6 publications

References 42 publications

A Narrative Review of Intestinal Microbiota’s Impact on Migraine with Psychopathologies

A Narrative Review of Intestinal Microbiota’s Impact on Migraine with Psychopathologies

Dairy and Headaches: What is the Connection?

Pediatric migraine is characterized by traits of ecological and metabolic dysbiosis and inflammation

Contact Info

Product

Resources

About