Lipopolysaccharides detection on a grating-coupled surface plasmon resonance smartphone biosensor

Jin-ling, Zhang; Khan, Imran; Zhang, Qingwen; Liu, Xiaohu; Dostálek, Jakub; Liedberg, Bo; Wang, Yi

doi:10.1016/j.bios.2017.07.048

Cited by 104 publications

(32 citation statements)

References 35 publications

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“…First, we developed a sensor that detects lipopolysaccharides (LPS), an endotoxin, which is part of the cell wall of Gram-negative bacteria and is shed into the bacterial environment 37,41 . For this purpose, a LPS-binding peptide [42][43][44] was conjugated to ssDNA/ SWCNTs 30,45 (Fig. 2a, Supplementary Fig.…”

Section: Resultsmentioning

confidence: 99%

Remote near infrared identification of pathogens with multiplexed nanosensors

et al. 2020

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Infectious diseases are worldwide a major cause of morbidity and mortality. Fast and specific detection of pathogens such as bacteria is needed to combat these diseases. Optimal methods would be non-invasive and without extensive sample-taking/processing. Here, we developed a set of near infrared (NIR) fluorescent nanosensors and used them for remote fingerprinting of clinically important bacteria. The nanosensors are based on single-walled carbon nanotubes (SWCNTs) that fluoresce in the NIR optical tissue transparency window, which offers ultra-low background and high tissue penetration. They are chemically tailored to detect released metabolites as well as specific virulence factors (lipopolysaccharides, siderophores, DNases, proteases) and integrated into functional hydrogel arrays with 9 different sensors. These hydrogels are exposed to clinical isolates of 6 important bacteria (Staphylococcus aureus, Escherichia coli,…) and remote (≥25 cm) NIR imaging allows to identify and distinguish bacteria. Sensors are also spectrally encoded (900 nm, 1000 nm, 1250 nm) to differentiate the two major pathogens P. aeruginosa as well as S. aureus and penetrate tissue (>5 mm). This type of multiplexing with NIR fluorescent nanosensors enables remote detection and differentiation of important pathogens and the potential for smart surfaces.

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Section: Resultsmentioning

confidence: 99%

Remote near infrared identification of pathogens with multiplexed nanosensors

et al. 2020

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“…Since then, various SPR refractive index sensing substrates have been coupled with smartphones, including optical fiber sensors [220,221], gratings [222], and plasmonic nanoarrays [223,224]. For example, Wang et al developed a grating-based SPR and a smartphone sensing system for lipopolysaccharides (LPS) detection with a LOD of 32.5 ng/mL in water [222]. This SPR sensing system relied on the smartphone's flash light as illumination source and an Au grating or compact disk (CD) as the spectral dispersive unit.…”

Section: Smartphone Microscopesmentioning

confidence: 99%

Plasmonic molecular assays: Recent advances and applications for mobile health

Wei

2018

Nano Res.

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Plasmonics-based biosensing assays have been extensively employed for biomedical applications. Significant advancements in use of plasmonic assays for the construction of point-of-care (POC) diagnostic methods have been made to provide effective and urgent health care of patients, especially in resourcelimited settings. This rapidly progressive research area, centered on the unique surface plasmon resonance (SPR) properties of metallic nanostructures with exceptional absorption and scattering abilities, has greatly facilitated the development of cost-effective, sensitive, and rapid strategies for disease diagnostics and improving patient healthcare in both developed and developing worlds. This review highlights the recent advances and applications of plasmonic technologies for highly sensitive protein and nucleic acid biomarker detection. In particular, we focus on the implementation and penetration of various plasmonic technologies in conventional molecular diagnostic assays, and discuss how such modification has resulted in simpler, faster, and more sensitive alternatives that are suited for point-of-use. Finally, integration of plasmonic molecular assays with various portable POC platforms for mobile health applications are highlighted.

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“…Biochemical applications of smartphone adapter (A) by Lee et al, adopted with permission from Elsevier Publishing; (B) by Michelini et al, adopted with permission from Elsevier Publishing; (C) by Ming et al, © copyright 2015, American Chemical Society; (D) by Xiao et al, under the Creative Commons license; (E) by Wang et al, adopted with permission from the Royal Society of Chemistry; (F) by Wang et al, adopted with permission from Elsevier Publishing; (G) by Yang et al, adopted with permission from Elsevier Publishing; (H) by Zangheri et al, adopted with permission from Elsevier Publishing; and (I) by Zhang et al, adopted with permission from Elsevier Publishing…”

Section: Resultsmentioning

confidence: 99%

“…The adapter demonstrated rapid and sensitive diagnostics. As shown in Figure I, Zhang et al developed a smartphone adapter based on grating‐coupled surface plasmon resonance (GC‐SPR) for biosensing. The adapter consists of a filter, a filter holder, a polarizer, a gold sensor chip with a diffraction grating, a compact disk (CD) transmission diffraction grating, a substrate, a sample holder, an aperture, and a plastic body.…”

Section: Resultsmentioning

confidence: 99%

A review of smartphone point‐of‐care adapter design

Alawsi

Al-Bawi

2019

Engineering Reports

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In this review, we explore the potential of smartphone‐based applications based on their unique ability to support portable, easy‐to‐use, precise, and efficient functions, which, in turn, makes lab‐on‐hardware a trending area of novel research. Smartphones can assist surgeons, physicians, biologists, chemists, ophthalmologists, and laboratory technicians in maintaining an easy‐to‐use, cost‐effective, and integrated environment for treatment, diagnosis, and point‐of‐care (POC) applications. These POC applications can improve patients' quality of life, offering patients a precise diagnosis and the correct treatment. This is a noble goal that aims to reduce costs and to increase the accuracy of sample testing, treatment, and diagnosis. Recent innovations have made major advances in smartphone adapters, providing portability, robustness, self‐powered devices, small‐sized adapters, and ease of usage. Lab‐on‐hardware is a progressing field, and smartphone imaging applications are increasingly expanding, resulting in POC applications with the latest and most advanced image analysis, enhancement, recognition, and other image processing techniques. The most recent studies in the field are explored to provide a solid background to interested researchers against which they can choose of application and/or adapter design they aim to develop, with a discussion of the methods reviewed here.

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Lipopolysaccharides detection on a grating-coupled surface plasmon resonance smartphone biosensor

Cited by 104 publications

References 35 publications

Remote near infrared identification of pathogens with multiplexed nanosensors

Remote near infrared identification of pathogens with multiplexed nanosensors

Plasmonic molecular assays: Recent advances and applications for mobile health

A review of smartphone point‐of‐care adapter design

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