Lipoprotein(a) is an independent risk factor for coronary artery disease in NIDDM patients in South India.

Mohan, Viswanathan; Deepa, R; Haranath, Sai Prashanth; Premalatha, G.; Rema, M.; Sastry, Nadiminti Ganapathi; Enas, E. A.

doi:10.2337/diacare.21.11.1819

Cited by 69 publications

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“…Lp(a) has been shown to be elevated in Indian heart patients (Gambhir et al, 2000) and was an independent risk factor for CHD in NIDDM patients in South India (Mohan et al, 1998). Lp(a) is elevated in South Asians living in North America (Anand et al, 1998;Hoogeveen et al, 2001) and in Britain (Bhatnagar, 1998) in comparison with host populations.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for coronary heart disease in two similar Indian population groups, one residing in India, and the other in Sydney, Australia

Mahajan

Bermingham

2004

Eur J Clin Nutr

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Objective: To identify the prevalence of coronary risk factors among South Asian Indians in Australia and India. Design: Cross-sectional intercountry comparison. Subjects: Healthy volunteers aged 23-75 y recruited from the Indian community in Sydney Australia (n¼125), and their nominated relatives in India, (n¼125). Results: The two groups were of similar background with over 90% of the group in India being siblings, parents or relatives of the group in Australia. There was no difference in the populations between India and Australia with regard to mean age (40711.5 vs 39710. Conclusion:The group in Australia (especially women) have a more favourable disease risk profile than those in India. The fact that the groups are of such similar background and partly related, make it unlikely that changes due to migration have a strong genetic bias. In contrast to other studies, the absence here of excessive weight gain on migration may be a key factor in disease risk prevention.

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Section: Introductionmentioning

confidence: 99%

Risk factors for coronary heart disease in two similar Indian population groups, one residing in India, and the other in Sydney, Australia

Mahajan

Bermingham

2004

Eur J Clin Nutr

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“…O possível papel dos níveis plasmáticos de Lp(a) no desenvolvimento de DAC em pacientes diabéticos é controverso. Alguns estudos demonstram a associação direta entre níveis plasmáticos de Lp(a) e o desenvolvimento de DAC (4,10,13,21,22,27) , enquanto outros demonstram o contrário (9,(23)(24)(25) . Gazzaruso et al (2001) (7) demonstraram que os níveis plasmáticos de Lp(a) foram independentemente associados com DAC em pacientes com DM, entretanto os níveis dessa lipoproteína comportaram-se como fator de risco cardiovascular menos importante em pacientes diabéticos do que em indivíduos não-diabéticos.…”

Section: Discussionunclassified

Correlação entre os níveis plasmáticos de apolipoproteínas A-I e B e o perfil lipídico em indivíduos com e sem diabetes mellitus tipo 2 e hipertensão arterial

Lima¹,

Carvalho²,

Soares³

et al. 2005

J. Bras. Patol. Med. Lab.

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y unitermos key words resumo Introdução: As dislipidemias, o diabetes mellitus (DM) e a hipertensão arterial sistêmica (HAS) são importantes fatores no desenvolvimento da doença arterial coronariana (DAC), a principal causa de morte de indivíduos adultos no mundo. Diversos estudos têm demonstrado correlação positiva entre concentrações plasmáticas elevadas de colesterol presente na lipoproteína de baixa densidade (LDL-C) e/ou baixas concentrações de colesterol presente na lipoproteína de alta densidade (HDL-C) e aumento de risco para doenças cardiovasculares (DCV). Objetivo: Correlacionar os valores do perfil lipídico, apolipoproteínas (Apo) A-I e B, lipoproteína(a) [Lp(a)] e microalbuminúria em indivíduos com e sem DM e HAS. Material e métodos: Os participantes, com faixa etária de 40 a 65 anos, foram divididos em cinco grupos: 1. controle (indivíduos hígidos, n = 16); 2. HAS (hipertensos, n = 12); 3. DM (DM2, normotensos e normoalbuminúricos, n = 7); 4. DM + HASnAlb (DM2, hipertensos e normoalbuminúricos, n = 18); e 5. DM + HASmAlb (DM2, hipertensos e microalbuminúricos, n = 9). Resultados: Foram observadas diferenças estatísticas para o LDL-C entre a média do grupo 5 em relação às médias dos demais grupos; para triglicérides (TGL), entre as médias dos grupos 2, 4 e 5 em relação à do grupo 1. Para as médias de colesterol total (CT), HDL-C, Lp(a) e Apo A-I não houve diferença significativa entre os grupos. As médias para Apo B dos grupos 4 e 5 apresentaram diferenças significativas com relação ao grupo 1. Foi observada correlação positiva entre o LDL-C e a Apo B (r = 0,684); p < 0,0001) e entre o HDL-C e a Apo A-I (r = 0,374; p = 0,003), de acordo com a literatura. Conclusão: Entre todos os parâmetros avaliados o LDL-C foi o único que apresentou diferenças significativas entre o grupo 5, cujos indivíduos apresentam as duas patologias combinadas (DM e HAS), além da microalbuminúria, em relação aos demais grupos estudados, sugerindo que a associação das duas patologias, aliada à presença de microalbuminúria, poderia ter contribuído para o agravamento da dislipidemia. Perfil lipídico ApolipoproteínasDiabetes mellitus tipo 2 A-I and B, Lipoprotein(a) 684); p < 0,0001) and 374; p = 0,003), according to literature. Conclusion: Among all parameters assessment, LDL-C was the unique one that showed significant differences between the group 5, whose participants present both alterations (DM and HAS) besides the microalbuminuria, related to other groups studied. This comes to suggest that the association between the two diseases allied to microalbuminuria may contribute to the dyslipidemia aggravation. Hipertensão arterial abstract Background: Dyslipidemias, diabetes mellitus (DM), high blood pressure are important factors for development of the coronary artery disease (CAD), principal cause of death in the world. Several studies have demonstrated positive correlation between both LDL-C high plasma levels and HDL-C low concentrations and increased risk for cardiovascular diseases. Objectives: To establish the possi...

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“…SA patients also have increased levels of other risk factors for CAD. In particular, the increased levels of lipoprotein(a), fibrinogen, homocysteine and plasminogen activator inhibitor-1, as documented in SA patients (15)(16)(17), can potentially further increase the risk of CAD. Elevated inflammatory markers, such as C-reactive protein, may also be associated with increased prevalence of CAD in this population (18).…”

Section: Discussionmentioning

confidence: 99%

Long-term prognosis of south Asians following acute coronary syndromes

Raghavan

Rahme

Nedjar

et al. 2008

Canadian Journal of Cardiology

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Lipoprotein(a) is an independent risk factor for coronary artery disease in NIDDM patients in South India.

Abstract: The data suggests that serum Lp(a) is an independent risk factor for CAD in NIDDM patients in South India.

Cited by 69 publications

References 0 publications

Risk factors for coronary heart disease in two similar Indian population groups, one residing in India, and the other in Sydney, Australia

Risk factors for coronary heart disease in two similar Indian population groups, one residing in India, and the other in Sydney, Australia

Correlação entre os níveis plasmáticos de apolipoproteínas A-I e B e o perfil lipídico em indivíduos com e sem diabetes mellitus tipo 2 e hipertensão arterial

Long-term prognosis of south Asians following acute coronary syndromes

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