Lipoprotein(a) levels are increased in healthy young subjects with parental history of premature myocardial infarction

Gaeta, Giovanni Battista; Cuomo, Sergio; Capozzi, Giovanbattista; Foglia, M; Barra, Silvia; Madrid, Alfredo; Stornaiuolo, Vincenzo; Trevisan, Maurizio

doi:10.1016/j.numecd.2007.03.006

Cited by 16 publications

(7 citation statements)

References 40 publications

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“…The ranking of Lp(a) levels at birth mirrored adult Singaporean coronary mortality rates by the three ethnic groups [70]. Lipoprotein(a) levels are also increased in healthy young subjects with a family history of premature MI [71–74]. Such observations have also been made among SAs [75].…”

Section: Resultsmentioning

confidence: 99%

South Asian Cardiovascular Disease & Cancer Risk: Genetics & Pathophysiology

Palaniappan

Garg

Enas³

et al. 2018

J Community Health

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South Asians (SAs) are at heightened risk for cardiovascular disease as compared to other ethnic groups, facing premature and more severe coronary artery disease, and decreased insulin sensitivity. This disease burden can only be partially explained by conventional risk factors, suggesting the need for a specific cardiovascular risk profile for SAs. Current research, as explored through a comprehensive literature review, suggests the existence of population specific genetic risk factors such as lipoprotein(a), as well as population specific gene modulating factors. This review catalogues the available research on cardiovascular disease and genetics, anthropometry, and pathophysiology, and cancer genetics among SAs, with a geographical focus on the U.S. A tailored risk profile will hinge upon population customized classification and treatment guidelines, informed by continued research.

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Section: Resultsmentioning

confidence: 99%

South Asian Cardiovascular Disease & Cancer Risk: Genetics & Pathophysiology

Palaniappan

Garg

Enas³

et al. 2018

J Community Health

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“…13 One of the candidate genes associated with EOCHD is LPA, which codes for apolipoprotein(a) (apo(a)), an apolipoprotein covalently bound to apoB 100 , thus forming lipoprotein(a) (Lp(a)), a highly atherogenic subclass of lowdensity lipoprotein (LDL) particles. [14][15][16] A low level of Lp(a) is associated with increased risk of new-onset T2DM and, among diabetics, with accelerated loss of BCF. 17 It is unclear whether Lp(a), which is genetically controlled, is involved in accruing BCF loss in T2DM patients with an FH of DM.…”

Section: Introductionmentioning

confidence: 99%

Crossing family histories of diabetes and cardiovascular disease leads to unexpected outcomes in diabetic offspring

Hermans

Ahn

Rousseau

2018

Journal of Diabetes

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Familial histories of DM and EOCHD predispose to increased microvascular and macrovascular risk, respectively, with hyperinsulinemia, lipoprotein(a), and dysfunctional HDLs standing out as mediators of the inherited macrovascular risk. Yet, crossing these FHs did not randomly redistribute vascular risk, because patients with parental T2DM had fewer macrovascular diseases regardless of familial EOCHD. The odds of being left-handed were unexpectedly greater in patients with crossed parental histories.

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“…In our study, the 9/26 children with high Lp(a) levels (34.62%) had a positive family history of premature CAD. Previous studies in children have also shown a positive correlation between high Lp(a) levels and family history of premature CAD [1, 27, 29, 30]. There are also studies showing ethnicity-related differences, with higher Lp(a) levels observed in African-American children [1, 27].…”

Section: Discussionmentioning

confidence: 89%

Similar Myocardial Perfusion and Vascular Stiffness in Children and Adolescents with High Lipoprotein (a) Levels, in Comparison with Healthy Controls

Papadopoulou-Legbelou

Triantafyllou²,

Vampertzi

et al. 2021

Pulse

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Background and Aims: This study investigated the possible correlation between elevated lipoprotein (a) (Lp(a)) levels and early vascular aging biomarkers in healthy children and adolescents. Methods: Twenty-seven healthy children/adolescents, mean age 9.9 ± 3.7 years, with high Lp(a) levels without other lipid abnormalities and 27 age- and sex-matched controls with normal Lp(a) levels, were included in the study. The investigation of possible early vascular aging was assessed by measuring vascular function indices: carotid intima-media thickness (c-IMT), pulse wave velocity (PWV), augmentation index (AIx), and subendocardial viability ratio (SEVR). Results: Although serum lipid values were within normal levels, mean values of total cholesterol and apolipoprotein B were higher in the group of children with high Lp(a) levels than controls (p = 0.006 and p < 0.001, respectively). Vascular function indices did not show significant differences, neither between the 2 groups nor in the subgroups of children with increased Lp(a) levels. These subgroups were defined by the presence or absence of family history of premature coronary artery disease. Lp(a) levels did not show a significant correlation with the other parameters studied, both regarding the whole sample (patients and controls), as well as in the subgroups of elevated Lp(a) levels. However, in the group of children with high Lp(a) levels, c-IMT and PWV were positively correlated with diastolic blood pressure (r = 0.427, p = 0.026 and r = 0.425, p = 0.030, respectively), while SEVR was negatively correlated with AIx (r = −0.455, p = 0.017). Conclusions: Healthy children and adolescents with high Lp(a) levels do not yet have impaired vascular indices, compared to controls. However, in order to prevent early atherosclerosis, it is crucial to early identify and follow up children with high Lp(a) levels and positive family history of premature coronary disease or other cardiovascular risk factors.

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Lipoprotein(a) levels are increased in healthy young subjects with parental history of premature myocardial infarction

Cited by 16 publications

References 40 publications

South Asian Cardiovascular Disease & Cancer Risk: Genetics & Pathophysiology

South Asian Cardiovascular Disease & Cancer Risk: Genetics & Pathophysiology

Crossing family histories of diabetes and cardiovascular disease leads to unexpected outcomes in diabetic offspring

Similar Myocardial Perfusion and Vascular Stiffness in Children and Adolescents with High Lipoprotein (a) Levels, in Comparison with Healthy Controls

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