Lipoprotein(a) : new insights into an atherogenic lipoprotein

Bartens, Werner; Wanner, Christoph

doi:10.1007/bf00227446

Cited by 26 publications

(15 citation statements)

References 98 publications

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“…pregnancy (7,(10)(11)(12)(13)(14), under the influence of drugs (19,25), oral contraceptives (17) and hormones (19,26,27), including gonadotropins (15,16). Results from animal studies (28) cannot be compared directly with results from humans (5) without due consideration of animal physiology.…”

Section: Resultsmentioning

confidence: 99%

“…Reports of behavour of lipoprotein(a) during pregnancy are also conflicting, some authors not seeing an increase (10,12,29), others reporting significant increases (11,13,14). In a study of smoking and non-smoking pregnant women, van Wersch et al (30) showed that the lipoprotein(a) levels in non-smoking pregnant women were on average twice as high as in women who smoked, the latter having the same concentrations as non-pregnant women.…”

Section: Resultsmentioning

confidence: 99%

“…The non-OniHian distribution of lipoprotein(a) concen-nanc y ( 7 > »O" 14 ). pituitary hormones (15,16) and diftrations, together with the wide range of concentrations ferent dru S s (»· I7~19 ) are weU documented, found in serum, allow only non-parametric statistics to be used.…”

Section: Introductionmentioning

confidence: 99%

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Do Gonadotropins Influence Serum Lipoprotein(a) Concentrations? Observations on Children, Adolescents and Adults

Schumacher¹,

Weigert²,

Wood³

1996

CCLM

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Summary:Data from 7045 subjects were examined. The main groups consisted of the following in-and outpatients: 1414 neonates, 2554 children and adolescents (1336 males, 1218 females), 1209 women directly postpartum, 786 non-pregnant women and 1090 men aged between 18 and 100 years of age. Unless otherwise stated, persons were under medical observation or therapy.The results were obtained over a three-year period using an in-house immunolurninometric assay specific for apolipoprotein(a) using two polyclonal antibodies and a single lot of reagents to allow for comparability of results.Girls aged between 10 and 12 years of age had significantly higher serum lipoprotein(a) (median 124 mg/1) levels than boys (median 88 mg/1) of the same age (p < 0.05 -Mann-Wliitney U-test). Post-pubertal lipoprotein(a) concentrations were not significantly different from pre-pubertal levels. Between the ages of 0-9 and 13-17 years there were no statistically significant sex-linked differences in serum lipoprotein(a).In adults, lipoprotein(a) serum levels were significantly higher in women (median 163 mg/1) aged between 50 and 59 years, when compared with men (median 128 mg/1) of the same age group (p = 0.05 -Kruskal-Wallis one way ANOVA followed by the Nemenyi test).There was no significant difference in serum lipoprotein(a) concentrations between healthy women (median 91 mg/1), women direct postpartum (median 116 mg/1) and in-patient women (median 117 mg/1) aged between 18 and 41 years of age (p = 0.11-0.96). There was no correlation between maternal lipoprotein(a) and birth weight in mature newborns (r = -0.028-0.085).The results may indicate a direct influence of gonadotropins at puberty and during the menopause which cause an increase in serum lipoprotein(a) concentrations.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Do Gonadotropins Influence Serum Lipoprotein(a) Concentrations? Observations on Children, Adolescents and Adults

Schumacher¹,

Weigert²,

Wood³

1996

CCLM

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“…Lp(a) is known to be synthesized almost exclusively by the liver [17] but its sites of catabolism and clearance are unknown. Lp(a) differs from LDL-C by having a larger particle size, higher buoyant density, higher neuraminic acid content, a different electrophoretic mobility, and a different protein composition [18]. Approximately 27% of the premature myocardial infarctions in men under 60 years of age have been attributed to increased Lp(a) levels [15,19].…”

Section: And Discussionmentioning

confidence: 99%

Plasma Lipoprotein(a) Levels Showing Age-Related Changes in Diabetic and Hypertensive Individuals.

Kulkarni

Viswanathan

1996

J. Clin. Biochem. Nutr.

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SummaryWe measured plasma levels of lipoprotein (a) [Lp(a)] in 117 individuals. A highly significant relationship between Lp(a) and increasing age was found in hypertensive patients but not in normals. These patients also showed marked variation in both total cholesterol and low-density lipoprotein (LDL)-cholesterol levels. In diabetic subjects, despite the significant elevation in TG and very low-density lipoprotein-cholesterol, the increase in Lp(a) concentration was not significant, probably due to a more rapid clearance of triglyceride rich particle apo (a) of Lp(a) compared to the slower apo (a) catabolism in the LDL density range.Key Words: lipoprotein(a), diabetes, hypertension, age Lipoprotein (a) [Lp(a)], an antigen variant of human low-density lipoprotein (LDL), has pre-fl mobility on lipoprotein electrophoresis but floats in a high density range between 1.05 to 1.10 g/ml during ultracentrifugation. Its protein moiety consists of apolipoprotein B-100 (apo B-loo) and a specific apolipoprotein a [apo (a)] that form a macromolecular complex linked together by a disulfide bridge [1,2]. Since apo (a) has an affinity for apo B-containing lipoprotein (apo B-Lp), enhanced binding of the apo (a) of Lp(a) to the arterial wall could increase the accumulation of LDL in the matrix and thus promote the development of cardiovascular disease (CVD) [3].Many case studies showed that high Lp(a) is an independent risk factor for premature CVD and that its level has a direct correlation with the disease. Studies carried out on Lp(a) concentrations in plasma indicated that the Lp(a) level is not modified by changes in diet, life style, or therapy with most lipid-lowering drugs except nicotinic acid; rather, it is genetically controlled [4][5][6][7][8]. Lp(a) also competes with plasminogen for binding to endothelial cells and macrophages, preventing

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“…Plasma levels exceeding 20 to 30 mg/dL have been associated with increased CV risk [210]. It has been suggested that Lp( ) may be more atherogenic when carrying small apo ( ) isoforms (defined as <22 kringle-4 repeats) than larger ones [211].…”

Section: Lipoprotein ( ) [Lp( )]mentioning

confidence: 99%

Associations of Thrombotic-Hemostatic Factors with Cardiovascular Disease~!2009-10-29~!2009-12-22~!2010-04-08~!

Lioudaki¹,

Ganotakis²

2012

TOCCHEMJ

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Cardiovascular disease (CVD) remains a leading cause of global morbidity and mortality despite identification of major cardiovascular (CV) risk factors and risk reduction via appropriate interventions. During the last years several markers have been studied as potential predictors of CV events. Hemostatic and thrombotic factors such as fibrinogen, homocysteine, factor VII, von Willebrand, tissue plasminogen activator, plasminogen activator inhibitor -1, D-dimer and lipoprotein ( ) have been found to be closely related to CVD. Many epidemiological studies have indicated that raised levels of these factors are associated with higher incidence of CVD, while some others have yielded conflicting results. As a consequence, it remains obscure whether they contribute to prediction of future CV events on top of conventional risk factors. Although data suggest that most of them are somehow implicated in CVD pathophysiology, it is not clearly defined yet whether treatment of abnormal levels leads to CV risk reduction. As a result measurement and treatment of these factors are justified only in exceptional cases. Further investigation is required in order to conclude whether and which of these factors may claim a position in everyday clinical practice.

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Lipoprotein(a) : new insights into an atherogenic lipoprotein

Cited by 26 publications

References 98 publications

Do Gonadotropins Influence Serum Lipoprotein(a) Concentrations? Observations on Children, Adolescents and Adults

Do Gonadotropins Influence Serum Lipoprotein(a) Concentrations? Observations on Children, Adolescents and Adults

Plasma Lipoprotein(a) Levels Showing Age-Related Changes in Diabetic and Hypertensive Individuals.

Associations of Thrombotic-Hemostatic Factors with Cardiovascular Disease~!2009-10-29~!2009-12-22~!2010-04-08~!

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