Lipoprotein-associated phospholipase A2 and arterial stiffness evaluation in patients with inflammatory bowel diseases

Theocharidou, Eleni; Tellis, Constantinos C.; Mavroudi, Melachrini; Soufleris, Konstantinos; Gossios, Thomas D.; Γιουλεμέ, Όλγα; Athyros, Vasilios G.; Tselepis, Alexandros D.; Karagiannis, Asterios

doi:10.1016/j.crohns.2014.01.016

Cited by 21 publications

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“…In total, 7092 articles were excluded according to a review of the title and the abstract only. The remaining 10 crosssectional studies, published within the last 5 years, reported PWV measurements for the IBD patients and their respective control patients [17][18][19][20][21][22][23][24][25][26]. One of these studies, which included 42 patients with IBD (Crohn's disease 60%) and 73 control patients, measured ab-PWV [17]; the main results of this study are reported in Tables 1 and 2.…”

Section: Discussionmentioning

confidence: 92%

“…One of these studies, which included 42 patients with IBD (Crohn's disease 60%) and 73 control patients, measured ab-PWV [17]; the main results of this study are reported in Tables 1 and 2. The remaining nine studies, which included 234 patients with Crohn's disease, 342 patients with ulcerative colitis, and 435 control patients, measured cf-PWV and were included in the metaanalysis [18][19][20][21][22][23][24][25][26]. The main results of these studies and the devices and techniques used to measure the cf-PWV are reported in Tables 1 and 2.…”

Section: Discussionmentioning

confidence: 99%

“…The main results of these studies and the devices and techniques used to measure the cf-PWV are reported in Tables 1 and 2. Furthermore, eight of the nine studies included in the meta-analysis reported the use of anti-TNFa therapy and were included in the metaregression analysis [18][19][20][21][22][23][24]26] ( Table 2).…”

Section: Discussionmentioning

confidence: 99%

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Arterial stiffness in inflammatory bowel disease

Zanoli

Rastelli

Basile

et al. 2016

Journal of Hypertension

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Arterial stiffness in inflammatory bowel disease

Zanoli

Rastelli

Basile

et al. 2016

Journal of Hypertension

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“…Em outro estudo, onde 73% dos pacientes com DII estavam em remissão, foram encontrados níveis de LDL-c e CT baixos tanto na DC como na RCU [24]. No presente estudo, tanto na DC quanto na RCU, verificaram-se níveis adequados de LDL-c, CT e TG, e apenas discreta redução do HDL-c nos pacientes com RCU que se encontravam em grave processo inflamatório, o que pode sugerir menor efeito protetor desse lipídeo na DII.…”

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Avaliação do perfil lipídico em pacientes com doença inflamatória intestinal

Adorne

Bodanese²

2016

Sci Med

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Este artigo está licenciado sob forma de uma licença Creative Commons Atribuição 4.0 Internacional, que permite uso irrestrito, distribuição e reprodução em qualquer meio, desde que a publicação original seja corretamente citada. Resultados: Participaram do estudo 122 pacientes de ambos os sexos com doença inflamatória intestinal, estratificados em: doença de Crohn (n=64) e retocolite ulcerativa (n=58). As mulheres representaram 54,1% da amostra, a média de idade foi de 41,6±12,6 anos e a média de índice de massa corporal foi de 25 ± 4,4kg/m 2 . O colesterol ligado à lipoproteína de baixa densidade (LDL-c) mostrou-se significativamente mais elevado nos pacientes com retocolite ulcerativa comparando-se aos pacientes com doença de Crohn (p=0,006). A proteína C reativa aumentada esteve associada com maior gravidade do processo inflamatório em pacientes com doença de Crohn (p=0,027), quando analisada pelo índice de Harvey-Bradshaw. Na retocolite ulcerativa, conforme o índice de Truelove e Witts, houve correlação fraca entre atividade da doença e colesterol ligado à lipoproteína de alta densidade (HDL-c) (r s = -0,29; p=0,036) e entre atividade da doença e colesterol total (r s = -0,30; p=0,028). Cerca de dois terços dos pacientes (67,6%) apresentaram o HDL-c abaixo dos valores recomendados. Conclusões: O LDL-c mostrou-se significativamente mais elevado nos pacientes com retocolite ulcerativa comparados aos pacientes com doença de Crohn. O HDL-c apresentou níveis reduzidos em pacientes com doença inflamatória mais grave na retocolite ulcerativa. A proteína C reativa aumentada em pacientes com doença de Crohn esteve associada com a gravidade do processo inflamatório determinada pelo índice de Harvey-Bradshaw. A detecção dessas alterações metabólicas pode auxiliar na identificação de indivíduos com potencial risco para eventos cardiovasculares. DESCRITORES: doença de Crohn; retocolite ulcerativa; dislipidemias. ABSTRACT Aims:To evaluate the lipid profile and inflammatory parameters in patients with Crohn's disease (CD), and ulcerative colitis (UC) and correlate them with disease activity levels. Methods: Cross-sectional study of patients followed up at the Inflammatory Bowel Disease Outpatient Clinic of São Lucas Hospital at Pontifícia Universidade Católica do Rio Grande do Sul, Brazil. The demographic, anthropometric, and metabolic characteristics of patients with chronic inflammatory disease were evaluated. Lipids and inflammatory parameters were evaluated as well as the correlation between the severity of inflammatory disease and metabolic parameters using the Harvey-Bradshaw index for CD and Truelove and Witts' method for UC. Results: The study included 122 male and female patients with inflammatory bowel disease classified into CD (n=64) and UC (n=58). Women accounted for 54.1% of the sample, with a mean age of 41.6±12.6 years and a BMI of 25±4.4kg/m 2 . Low-density lipoprotein cholesterol (LDL-c) was significantly higher in UC than in CD (p=0.006). Higher C-reactive protein levels were associated with a more seve...

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“…There is an increasing number of mainly small studies that utilized noninvasive markers of atherosclerosis, such as carotid intima-media thickness and aortic stiffness as estimated by carotid-femoral pulse wave velocity, to predict the risk of cardiovascular disease (CVD) in these patients. 3,4 Several of these studies have demonstrated early changes in the arterial wall reflecting increased risk of atherosclerosis and CVD events. 5 It has been hypothesized that chronic systemic inflammation can precipitate proatherogenic changes via the circulation of proinflammatory cytokines, such as tumor necrosis factor a and interleukin 6.…”

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confidence: 99%

Acute Coronary Syndrome in Patients With Inflammatory Bowel Diseases: The Plaque and the Thrombus

2017

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The risk of acute coronary syndrome (ACS) in patients with inflammatory bowel disease (IBD) has to this point not been studied prospectively. A meta-analysis of 9 retrospective studies including approximately 150 000 patients with IBD demonstrated an increase of 18% in the risk of myocardial infarction (MI) and stroke compared to the general population.1 This observation has been challenged by a more recent study that included more than 550 000 inpatients with IBD from a US Nationwide Database and demonstrated a significantly lower risk of MI in these patients.

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Lipoprotein-associated phospholipase A2 and arterial stiffness evaluation in patients with inflammatory bowel diseases

Cited by 21 publications

References 44 publications

Arterial stiffness in inflammatory bowel disease

Arterial stiffness in inflammatory bowel disease

Avaliação do perfil lipídico em pacientes com doença inflamatória intestinal

Acute Coronary Syndrome in Patients With Inflammatory Bowel Diseases: The Plaque and the Thrombus

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