Lipoprotein-associated Phospholipase A2 Is Associated with Risk of Mild Cognitive Impairment in Chinese Patients with Type 2 Diabetes

Cai, Rongrong; Huang, Rong; Han, Jing; Sun, Hao; Sun, Jie; Xia, Wenqing; Tian, Sai; Xue, Dong; Shen, Yanjue; Wang, Zhanpeng

doi:10.1038/s41598-017-12515-z

Cited by 20 publications

(23 citation statements)

References 75 publications

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“…Our findings were similar to a cross-sectional study from Scotland [12], which has shown that IL-6 was associated with estimated lifetime cognitive status after adjusting for vocabulary, education level, cardiovascular dysfunction, duration of diabetes, and glycemic control in older patients with T2D. The findings of a recent study from China have also suggested that plasma hs-CRP was associated with the risk of MCI among T2D patients [11]. Meanwhile, another Chinese case-control study in T2D has reported that the patients with MCI have a significantly higher hs-CRP than those without MCI, but CRP was not significantly correlated with the cognitive status [34].…”

Section: Discussionsupporting

confidence: 89%

“…In previous, one cohort study of 168 Chinese elderly patients has demonstrated that plasma high-sensitivity C-reactive protein (hs-CRP) level was associated with cognitive function and development of dementia in non-diabetics [10]. Currently, several epidemiological studies have focus on the association between inflammatory markers and the risk of MCI in T2D patients [11, 12], which showed that hs-CRP or IL-6 were found to be associated with the risk of MCI among T2D patients. Moreover, it has been reported that MCI was often associated with folate [8] and folic acid supplementation appeared to improve cognitive function and reduce blood levels of Aβ-related biomarkers in MCI [13].…”

Section: Introductionmentioning

confidence: 99%

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Relationship between inflammatory markers and mild cognitive impairment in Chinese patients with type 2 diabetes: a case-control study

et al. 2019

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Background Several studies have indicated that inflammatory markers were associated with the risk of mild cognitive impairment (MCI) in type 2 diabetes (T2D). Serum folate was related to MCI as well as inflammation. However, no studies have investigated the association between inflammatory markers and MCI taking account of serum folate level in T2D patients. This study aimed to conduct a case-control study to evaluate the association between inflammatory markers and MCI taking account of serum folate level in Chinese patients with T2D. Methods This study consisted of 126 T2D patients (63 cases with MCI and 63 controls without MCI). Clinical parameters, serum folate, high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) were measured. Spearman correlation analysis and logistic regression analysis were used to analyze the association between the inflammatory markers and the risk of MCI in T2D patients. Results There were higher serum hs-CRP, IL-6 and TNF-α in T2D cases with MCI compared with the controls. Serum folate was negatively correlated with hs-CRP, TNF-α, and IL-6 ( P < 0.05). In multivariate analysis, there were significant associations between serum IL-6 or hs-CRP and MCI after adjusting for the confounding variables, however, the association between hs-CRP and MCI disappeared after further adjusting for serum folate. Further subgroup analysis revealed that the significant association between hs-CRP and MCI only existed in the low folate subgroup (< 7.0 μg/L; OR = 3.34, 95% CI: 1.05–10.64), not in the high folate subgroup (≥7.0 μg/L; OR = 2.16, 95% CI: 0.68–6.88) after adjusting for the confounding variables. Conclusions Serum IL-6 and hs-CRP were associated with the risk of MCI in Chinese patients with T2D. Serum folate might modify the association between serum hs-CRP and MCI in T2D patients.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Relationship between inflammatory markers and mild cognitive impairment in Chinese patients with type 2 diabetes: a case-control study

et al. 2019

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“…This hypothesis is supported by data showing that higher Lp-PLA2 mass/activity is an independent risk factor for MCI in type 2 diabetes mellitus patients. In light of these observations, Lp-PLA2 might represent a central player in the vicious circle leading to the accumulation of inflammatory cells and cytokines and vascular deficit [ 96 ].…”

Section: Lipoprotein Phospholipase A2 (Lp-pla2)mentioning

confidence: 99%

Connection between the Altered HDL Antioxidant and Anti‐Inflammatory Properties and the Risk to Develop Alzheimer’s Disease: A Narrative Review

Zimetti

Adorni

Marsillach

et al. 2021

Oxidative Medicine and Cellular Longevity

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The protein composition of high-density lipoprotein (HDL) is extremely fluid. The quantity and quality of protein constituents drive the multiple biological functions of these lipoproteins, which include the ability to contrast atherogenesis, sustained inflammation, and toxic effects of reactive species. Several diseases where inflammation and oxidative stress participate in the pathogenetic process are characterized by perturbation in the HDL proteome. This change inevitably affects the functionality of the lipoprotein. An enlightening example in this frame comes from the literature on Alzheimer’s disease (AD). Growing lines of epidemiological evidence suggest that loss of HDL-associated proteins, such as lipoprotein phospholipase A2 (Lp-PLA2), glutathione peroxidase-3 (GPx-3), and paraoxonase-1 and paraoxonase-3 (PON1, PON3), may be a feature of AD, even at the early stage. Moreover, the decrease in these enzymes with antioxidant/defensive action appears to be accompanied by a parallel increase of prooxidant and proinflammatory mediators, in particular myeloperoxidase (MPO) and serum amyloid A (SAA). This type of derangement of balance between two opposite forces makes HDL dysfunctional, i.e., unable to exert its “natural” vasculoprotective property. In this review, we summarized and critically analyzed the most significant findings linking HDL accessory proteins and AD. We also discuss the most convincing hypothesis explaining the mechanism by which an observed systemic occurrence may have repercussions in the brain.

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“…These clinical studies indicate Lp‐PLA2 as an independent risk factor for these inflammation‐related conditions. In addition, another study observed that Lp‐PLA2 is associated with a higher risk of developing mild cognitive impairment in type two diabetes mellitus patients . Thus, this inflammatory factor can be used as an indicator of multiple diseases depending on context.…”

Section: Introductionmentioning

confidence: 99%

Measuring lipoprotein‐associated phospholipase A2 activity in China: Protocol comparison and recalibration

Wang

Guo

Hou

et al. 2018

Clinical Laboratory Analysis

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Lipoprotein-associated Phospholipase A2 Is Associated with Risk of Mild Cognitive Impairment in Chinese Patients with Type 2 Diabetes

Cited by 20 publications

References 75 publications

Relationship between inflammatory markers and mild cognitive impairment in Chinese patients with type 2 diabetes: a case-control study

Relationship between inflammatory markers and mild cognitive impairment in Chinese patients with type 2 diabetes: a case-control study

Connection between the Altered HDL Antioxidant and Anti‐Inflammatory Properties and the Risk to Develop Alzheimer’s Disease: A Narrative Review

Measuring lipoprotein‐associated phospholipase A2 activity in China: Protocol comparison and recalibration

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