Lipoprotein‐associated phospholipase A2: The story continues

Huang, Fubao; Wang, Kai; Shen, Jianhua

doi:10.1002/med.21597

Cited by 131 publications

(149 citation statements)

References 270 publications

(736 reference statements)

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“…With the stimulation of INF-α/β/γ and 5-HT2R, PLA activity increases as well (Kurrasch-Orbaugh 2003;Wu et al, 1994). Conversely, PLA2 deactivates in response to glutamine and oxidants (Huang et al, 2020;.…”

Section: Membrane Phospholipidsmentioning

confidence: 99%

Lipid composition of the cancer cell membrane

Szlasa

Zendran

Zalesińska

et al. 2020

J Bioenerg Biomembr

264

191

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Cancer cell possesses numerous adaptations to resist the immune system response and chemotherapy. One of the most significant properties of the neoplastic cells is the altered lipid metabolism, and consequently, the abnormal cell membrane composition. Like in the case of phosphatidylcholine, these changes result in the modulation of certain enzymes and accumulation of energetic material, which could be used for a higher proliferation rate. The changes are so prominent, that some lipids, such as phosphatidylserines, could even be considered as the cancer biomarkers. Additionally, some changes of biophysical properties of cell membranes lead to the higher resistance to chemotherapy, and finally to the disturbances in signalling pathways. Namely, the increased levels of certain lipids, like for instance phosphatidylserine, lead to the attenuation of the immune system response. Also, changes in lipid saturation prevent the cells from demanding conditions of the microenvironment. Particularly interesting is the significance of cell membrane cholesterol content in the modulation of metastasis. This review paper discusses the roles of each lipid type in cancer physiology. The review combined theoretical data with clinical studies to show novel therapeutic options concerning the modulation of cell membranes in oncology.

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Section: Membrane Phospholipidsmentioning

confidence: 99%

Lipid composition of the cancer cell membrane

Szlasa

Zendran

Zalesińska

et al. 2020

J Bioenerg Biomembr

264

191

View full text Add to dashboard Cite

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“…Approximately 80% of Lp-PLA2 circulates bound to LDL, whereas the other 20% is bound to HDL and very low-density lipoprotein (VLDL) (31). Lp-PLA2 can hydrolyze oxPL at the surface of LDL, which produces a variety of cytokines, adhesion factors, and promotes the formation of atherosclerotic plaques (32). Meanwhile, histopathological examinations have shown that Lp-PLA2 is highly expressed in the late necrotic core of atheromatous plaque, suggesting that it is involved in the formation and development of vulnerable atherosclerotic plaques (33).…”

Section: Discussionmentioning

confidence: 99%

Association Between Plasma Lipoprotein-Associated Phospholipase A2 and Plaque Vulnerability in TIA Patients With Unilateral Middle Cerebral Artery Stenosis

Qin

Qian

Li³

et al. 2020

Front. Neurol.

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Background: Plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) has emerged as a novel biomarker for coronary atherosclerosis. However, the association between Lp-PLA2 and plaque vulnerability in atherosclerosis of cervicocerebral arteries remains poorly defined, especially for intracranial atherosclerotic stenosis (ICAS). We aimed to investigate the association between Lp-PLA2 and plaque vulnerability in transient ischemic attack (TIA) patients with unilateral middle cerebral artery stenoses (MCAs). Methods: In this study, a total of 207 patients were enrolled from April 2017 to April 2020. Clinical data were collected, and MCA plaques were examined with high-resolution magnetic resonance imaging (HRMRI). Baseline characteristics of patients were collected during hospitalization. Statistical comparisons were performed using Pearson's chi-squared test, Mann-Whitney U test, and the Breslow-Day/Tarone's test for the determination of heterogeneity in different age strata. Multivariate binary logistic analysis was used to investigate the potential independent predictors that were highly correlated to plaque vulnerability. Results: The results showed that a high Lp-PLA2 level (>221 ng/ml) was associated with plaque vulnerability in TIA patients with unilateral MCAs. High Lp-PLA2 was independently associated with plaque vulnerability in patients ≤60 years old [multivariate adjusted odds ratio (OR) = 9.854; 95% CI, 2.458-39.501] but not in patients >60 years old (multivariate adjusted OR = 1.901; 95% CI, 0.640-5.650). Predictors of plaque vulnerability in different age strata were also different. Conclusion: Lp-PLA2 levels may be correlated to plaque vulnerability in TIA patients with unilateral MCAs and might be a diagnostic biomarker for plaque vulnerability in this kind of patients, especially for ones aged ≤60 years old.

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“…Besides, it contributed to the pathogenesis of atherosclerosis [31] and mediation of inflammation [29,32]. Moreover, it could mediate the vasculitis through regulating the metabolism of blood fat [33]. To our best knowledge, rare studies have been focused on the roles of Lp-PLA2 in the WMH.…”

Section: Moreover No Correlation Was Noticed Between Serum Lp-pla2 Amentioning

confidence: 99%

Differential effects of serum lipoprotein-associated phospholipase A2 on periventricular and deep subcortical white matter hyperintensity in brain

Jiang

Gao

Zhang

et al. 2020

Preprint

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Background: High lipoprotein-associated phospholipase A2 (Lp-PLA2) was associated with white matter hyperintensity (WMH). There were differences in the anatomical structure and pathophysiological mechanism between periventricular WMH (PVWMH) and deep subcortical WMH (DSWMH). In this study, we aimed to investigate the effects of serum Lp-PLA2 on the PVWMH and DSWMH. Methods: This cross-sectional study recruited 711 Chinese adults aged ≥45 years presented to the Department of Neurology, the Affiliated Jiangning Hospital of Nanjing Medical University between January 2016 and July 2019. Enzyme linked immunosorbent assay (ELISA) was utilized to determine the serum Lp-PLA2. Fazekas scale was used to measure the severity of PVWMH and DSWMH. Ordinal logistic regression analysis was carried out to investigate the relationship between serum Lp-PLA2 and PVWMH or DSWMH. Results: A total of 567 cases were included in this study. Ordinal logistic regression analysis indicated that, after adjusting for the confounding variables, there was a lower risk of PVWMH in the patients with normal and moderately elevated serum Lp-PLA2 compared with those with significantly elevated serum Lp-PLA2. In addition, PVWMH was correlated to advanced age, hypertension, diabetes mellitus, and lacunar infarction. DSWMH was correlated to advanced age and lacunar infarction. There was no correlation between serum Lp-PLA2 and DSWMH. Conclusions: Serum Lp-PLA2 was closely associated with the pathogenesis of PVWMH rather than DSWMH. There might be different pathological mechanisms between PVWMH and DSWMH.

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Lipoprotein‐associated phospholipase A2: The story continues

Cited by 131 publications

References 270 publications

Lipid composition of the cancer cell membrane

Lipid composition of the cancer cell membrane

Association Between Plasma Lipoprotein-Associated Phospholipase A2 and Plaque Vulnerability in TIA Patients With Unilateral Middle Cerebral Artery Stenosis

Differential effects of serum lipoprotein-associated phospholipase A2 on periventricular and deep subcortical white matter hyperintensity in brain

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