Lipoprotein fractions, lipoprotein lipase and hepatic triglyceride lipase during short-term and long-term uptake of ethanol in healthy subjects

Schneider, Jürgen; Liesenfeld, A.; Mordasini, R; Schubotz, R; Zöfel, P.; Kubel, F.; Vandré-Plozzitzka, C.; Kaffarnik, H

doi:10.1016/0021-9150(85)90040-1

Cited by 65 publications

(31 citation statements)

References 24 publications

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“…Observations in alcoholic patients before and after alcohol withdrawal suggested further that, in addition to increased synthesis of apoA-I (46 -48) and changes in lipase activity (20,23,49,50), the combination of reduced CETP activity and increased PLTP activity may account for the shift of the plasma HDL fraction toward the large HDL 2a and HDL 2b subpopulations in alcoholic patients.…”

Section: Table IVmentioning

confidence: 99%

Opposite Effects of Cholesteryl Ester Transfer Protein and Phospholipid Transfer Protein on the Size Distribution of Plasma High Density Lipoproteins

Lagrost

Athias

Herbeth

et al. 1996

Journal of Biological Chemistry

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The aim of the present study was to investigate the role of the cholesteryl ester transfer protein (CETP) and the phospholipid transfer protein (PLTP) in determining the size distribution of high density lipoproteins (HDL) in human plasma. Whereas both purified CETP and PLTP preparations were able to promote the size redistribution of isolated HDL 3 , CETP favored the emergence of small HDL, while PLTP induced the formation of both small and large conversion products. When the total plasma lipoprotein fractions isolated from nine distinct subjects were incubated for 24 h at 37°C with either purified PLTP or purified CETP, significant alterations in the relative proportions of the five distinct plasma HDL subpopulations, i.e., HDL 2b (9.71-12.90 nm), HDL 2a (8.77-9.71 nm), HDL 3a (8.17-8.77 nm), HDL 3b (7.76 -8.17 nm), and HDL 3c (7.21-7.76 nm) were also observed. PLTP induced a significant increase in the relative abundance of HDL 2b (8.66 ؎ 2.34% versus 7.87 ؎ 1.83% in controls; p < 0.01) and a significant decrease in the relative abundance of HDL 3a (32.76 ؎ 3.42% versus 37.87 ؎ 2.62% in controls; p < 0.05). In contrast, CETP significantly reduced the relative proportion of HDL 2a (33.03 ؎ 2.53% versus 37.56 ؎ 6.43% in controls; p < 0.01) but significantly increased the relative proportion of both HDL 3b (21.36 ؎ 6.97% versus 15.58 ؎ 7.75% in controls; p < 0.01) and HDL 3c (3.21 ؎ 4.84% versus 1.13 ؎ 0.56% in controls; p < 0.05). Finally, in order to assess further the physiological relevance of in vitro observations, CETP activity, PLTP activity, and HDL size distribution were determined in plasmas from 33 alcoholic patients entering a cessation program. Alcohol withdrawal was associated with (i) a significant increase in plasma CETP activity (173.5 ؎ 70.5%/h/ml before versus 223.2 ؎ 69.3%/h/ml after alcohol withdrawal, p ‫؍‬ 0.0007), (ii) a significant reduction in plasma PLTP activity (473.9 ؎ 203.7%/h/ml before versus 312.7 ؎ 148.4%/h/ml after alcohol withdrawal, p ‫؍‬ 0. In human plasma, five distinct high density lipoprotein (HDL) 1 subpopulations have been identified on the basis of their apparent diameter as determined by using polyacrylamide gradient gel electrophoresis: HDL 2b (9.71-12.90 nm), HDL 2a (8.77-9.71 nm), HDL 3a (8.17-8.77 nm), HDL 3b (7.76 -8.17 nm), and HDL 3c (7.21-7.76 nm) (1). The heterogeneity of HDL in terms of size distribution may be of physiopathological relevance, and Cheung and coworkers (2) reported significant alterations in HDL size in patients with symptomatic coronary artery disease as compared with healthy control subjects. Interestingly, the presence of coronary artery disease was more strongly associated with abnormalities in HDL particle size distribution than with low HDL cholesterol levels (2). Therefore, these observations raised a considerable interest in identifying the factors that can induce alterations in the relative proportions of plasma HDL 2b , HDL 2a , HDL 3a , HDL 3b , and HDL 3c subfractions in vivo.It is now well established that plasma lipoproteins do ...

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Section: Table IVmentioning

confidence: 99%

Opposite Effects of Cholesteryl Ester Transfer Protein and Phospholipid Transfer Protein on the Size Distribution of Plasma High Density Lipoproteins

Lagrost

Athias

Herbeth

et al. 1996

Journal of Biological Chemistry

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“…Alcohol-induced increase in activity of lipoprotein lipase which transfers of cholesterol and phospholipids from triglyceride-rich lipoproteins to HDL during the lipolysis may be a possible explanation for HDL-C increase due to alcohol consumption [11,12].…”

Section: Resultsmentioning

confidence: 99%

Effects of Alcohol Consumption on HDL Metabolism in Asian Populations

Yanai

2014

J Endocrinol Metab

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Low serum high-density lipoprotein-cholesterol (HDL-C) is an independent coronary risk factor, because HDL acts to mediate the uptake of peripheral cholesterol and return it to the liver. Therefore, raising HDL-C may be one of the goals in the management of atherogenic dyslipidemia for cardiovascular disease risk reduction. Although lifestyle modification such as diet and exercise may be important to increase HDL-C, effects of dietary factors on HDL-C remained largely unknown. Interracial differences on HDL metabolism may exist. Here we reviewed published articles about effect of alcohol consumption on HDL metabolism in Asian populations, regarding systematic review and meta-analysis and also clinical studies performed in Asian populations as important articles in this review.

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“…Furthermore, cigarette smoking increases beta lipoproteins, and this effect is secondary to the higher very low density lipoprotein (VLDL) triglyceride levels in whole serum and a VLDL fraction in smokers 28) . The rise in serum triglycerides caused by alcohol is mainly due to increased synthesis of triglycerides in VLDL 29,30) . There is the abundant evidence that serum triglycerides independently predict initial CHD events 1-3, 5, 6, 31-36) , and mild to moderately elevated levels generally considered as normal are associated with CHD risk 5,6,35,36) .…”

Section: Discussionmentioning

confidence: 99%

Distribution and Cardiovascular Risk Correlates of Serum Triglycerides in Young Japanese Adults.

et al. 2002

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To examine the distribution and cardiovascular risk correlates of serum triglycerides, a cross-sectional population study based on annual health examinations at the workplace was performed in 2199 young Japanese adults aged 23 to 37 years. Triglyceride levels showed significant sex (male > female) differences, and the percentages of those with high triglycerides (≥ 150 mg/dl) were 9.4% for males and 0.8% for females. In terms of conjoint trait of dyslipidemia, 86.1% of males displayed normal levels of both triglycerides (< 150 mg/dl) and high-density lipoprotein (HDL) cholesterol (≥ 40 mg/dl), while 98.7% of females had normal values. Age-and sex-specific triglyceride levels above the 75th percentile (equivalent to 82-116 mg/dl for males and 56-63 mg/dl for females) increased the risk (odds ratio (OR)) for having obesity, hypertension, and hyperuricemia by 2.9 (95% confidence interval (CI)=2.0-4.3), 1.7 (CI=1.1-2.9), and 3.0 (CI=1.6-5.9), respectively. The respective ORs for triglyceride levels above the 75th percentile and HDL cholesterol below the 25th percentile (equivalent to 45-49 mg/dl for males and 58-63 mg/dl for females), compared with triglyceride levels the 75th percentile or less and HDL cholesterol levels the 25th percentile or more, were 8.7 (CI=5.8-12.9), 2.2 (CI=1.5-3.3), and 6.0 (CI=3.2-11.5). Our results suggest a threshold effect of triglyceride levels considered as normal on enhanced cardiovascular risk in young Japanese adults, especially in those with low HDL cholesterol levels.

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Lipoprotein fractions, lipoprotein lipase and hepatic triglyceride lipase during short-term and long-term uptake of ethanol in healthy subjects

Cited by 65 publications

References 24 publications

Opposite Effects of Cholesteryl Ester Transfer Protein and Phospholipid Transfer Protein on the Size Distribution of Plasma High Density Lipoproteins

Opposite Effects of Cholesteryl Ester Transfer Protein and Phospholipid Transfer Protein on the Size Distribution of Plasma High Density Lipoproteins

Effects of Alcohol Consumption on HDL Metabolism in Asian Populations

Distribution and Cardiovascular Risk Correlates of Serum Triglycerides in Young Japanese Adults.

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