Lipoprotein lipase: From gene to atherosclerosis

Li, Yuan; He, Ping; Zhang, Da Wei; Zheng, Xi-Long; Cayabyab, Fracisco S.; Yin, Wang; Tang, Chao-Ke

doi:10.1016/j.atherosclerosis.2014.10.016

Cited by 104 publications

(72 citation statements)

References 195 publications

(152 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…LPL not only interacts with triglycerides during the pathogenesis of atherosclerosis but also promotes retention of LDL-C within the intimal space by binding LDL-C to proteoglycans, found on smooth muscle cells. This retention allows more time for LDL-C particle modification and subsequently promotes uptake by macrophages (Li et al 2014). However, whether LPL is antiatherogenic or proatherogenic is dependent on the cell/tissue that is expressing the enzyme (Mead and Ramji 2002).…”

Section: Sedentary Behaviour and Physical Activity: Impact On Glucosementioning

confidence: 99%

The emergence of sedentary behaviour physiology and its effects on the cardiometabolic profile in young and older adults

Ryan

Stebbings

Onambélé

2015

AGE

View full text Add to dashboard Cite

It has recently emerged that sedentary behaviour is independent of a lack of physical activity as individuals can be sufficiently active, based on the recommended physical activity guidelines, but also spend the majority of their waking hours engaging in sedentary behaviour. Individuals who follow this pattern of physical activity and sedentary behaviour are known as 'active couch potatoes'. Sedentary behaviour has been found to have detrimental effects on cardiometabolic markers associated with cardiovascular disease. Since the positive effects of moderate-to-vigorous intensity physical activity do not necessarily negate the deleterious effects of sedentary behaviour on cardiometabolic markers, it is postulated that engaging in light physical activity is an intervention that will successfully reduce levels of sedentary behaviour and may hence improve health markers of quality of life. We propose that such lifestyle changes may be particularly relevant to older populations as these engage in sedentary behaviour for the majority of their waking hours, thereby adding to the negative aging effect on cardiometabolic markers.

show abstract

Section: Sedentary Behaviour and Physical Activity: Impact On Glucosementioning

confidence: 99%

The emergence of sedentary behaviour physiology and its effects on the cardiometabolic profile in young and older adults

Ryan

Stebbings

Onambélé

2015

AGE

View full text Add to dashboard Cite

show abstract

“…LPL regulation in diabetes has been recently reviewed [51]. Both glucocorticoids and insulin are essential for LPL translation [52].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…LPL-mediated lipolysis is generally considered rate-limiting for tissue TAG utilisation. It has a complex cell biology which is not yet fully elucidated (see [51,52,62]. The attachment of mature, active LPL to EC-H"PG GPIHBP [63] permitting plasma TAG hydrolysis [64].…”

Section: Lipoprotein Lipase Mediated Myocardial Tag Uptakementioning

confidence: 99%

See 1 more Smart Citation

The role of triacylglycerol in cardiac energy provision

Evans

Hui‐Kang

2016

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

View full text Add to dashboard Cite

Triacylglycerols (TAG) constitute the main energy storage resource in mammals, by virtue of their high energy density. This in turn is a function of their highly reduced state and hydrophobicity.Limited water solubility, however, imposes specific requirements for delivery and uptake mechanisms on TAG-utilising tissues, including the heart, as well as intracellular disposition. TAGs constitute potentially the major energy supply for working myocardium, both through bloodborne provision and as intracellular TAG within lipid droplets, but also provide the heart with fatty acids (FA) which the myocardium cannot itself synthesise but are required for glycerolipid derivatives with (non-energetic) functions, including membrane phospholipids and lipid signalling molecules. Furthermore they serve to buffer potentially toxic amphipathic fatty acid derivatives.Intracellular handling and disposition of TAGs and their FA and glycerolipid derivatives similarly requires dedicated mechanisms in view of their hydrophobic character. Dysregulation of utilisation can result in inadequate energy provision, accumulation of TAG and/or esterified species, and these may be responsible for significant cardiac dysfunction in a variety of disease states. This review will focus on the role of TAG in myocardial energy provision, by providing FAs from exogenous and endogenous TAG sources for mitochondrial oxidation and ATP production, and how this can change in disease and impact on cardiac function. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 3Key words:heart; triacylglycerol; very-low-density lipoprotein; VLDL; chylomicron; lipid droplet Highlights: Triacylglycerols are supplied to the myocardium within chylomicrons and VLDL  Heart assimilates triacylglycerol-rich lipoproteins by LPL and receptor-mediated routes  Exogenous triacylglycerol-derived fatty acids enter an intracellular lipid pool  Intracardiac triacylglycerol is an important source of fatty acids for oxidation  Dysregulation of triacylglycerol metabolism is associated with cardiac dysfunction

show abstract

“…This results when the breakdown of triglyceride (TG) rich very low density lipoproteins (VLDL) and chylomicrons is interrupted. The key step in degradation of both chylomicrons and VLDL is lipoprotein lipase (LPL) 2. The activity of LPL requires the presence of insulin and therefore, in insulin deficient and resistant states, the clearance of TG‐rich lipoproteins is impaired 3, 4.…”

Section: Introductionmentioning

confidence: 99%