Lipoprotein Lipase Gene Polymorphisms in Croatian Patients with Coronary Artery Disease

Abstract

Modifications in lipoprotein lipase levels lead to elevated triglycerides and reduced high density lipoprotein (HDL), both of which are risk factors for coronary artery disease (CAD). Hence, we examined the influence of the -93T/G, D9N, N291S, and S447X polymorphisms in the lipoprotein lipase (LPL) gene on CAD risk and lipid levels in Croatian patients with and without angiographically confirmed CAD. The N291S polymorphism was significantly associated with CAD (OR = 0.36; 95% CI = 0.13, 0.99; p = 0.048). This association was only moderately affected by adjusting for various lipids (OR = 0.36; 95% CI = 0.12, 1.08; p = 0.068). HDL2-cholesterol and apolipoprotein A-I levels were significantly higher in non-carriers of the -93T/G and D9N polymorphisms in the CAD group (p = 0.017 and 0.028, respectively). The N291S genetic variant did not show any significant difference between carriers and non-carriers in either group studied for any of the lipids. Lower triglyceride and higher HDL2-cholesterol levels in the control group were associated with carriers of the S447X mutation (p = 0.043 and 0.056, respectively). LPL gene polymorphisms might be involved in predisposition to CAD and determination of lipid profiles.

A systematic review and meta-analysis of the relationship between lipoprotein lipase Asn291Ser variant and diseases

“…Of the 21 included publications, nine provided separate associations in different populations (7,8,11,14,16,18,21,24,26). These associations were considered as separate studies.…”

“…Based on 13 studies published up to 1997 (27), Asn291Ser heterozygous carriers had an average increase in plasma TG of 31% and an average decrease in HDL-C of 0.12 mM (P , 0.001). However, since then, a number of other studies have been published in which no association was observed (10,18,20,21,24). In addition to study power and other methodological issues, interactions with important dyslipidemic risk factors such as increasing age and weight gain could have resulted in heterogeneous findings.…”

Polymorphisms in APOA1 and LPL genes are statistically independently associated with fasting TG in men with CAD

“…Several studies found a similar association, 8,42 -44 while others did not find an association between LPL Asn291Ser and TG levels. 45,46 Carriers of LPL Asn291Ser are found to have modest decreases of LPL activity and higher TG levels. 47 In the present study, data on LPL activity were available.…”

Associations of three lipoprotein lipase gene polymorphisms, lipid profiles and coronary artery disease

“…However, Hallman et al (10) did not find any association between the HindIII(-) allele and higher LPL activity. The associations of certain polymorphic loci in the LPL promoter, introns or exons with lipid disorders and coronary artery disease (CAD) have been reported by some groups (rs285, rs1800590, rs320, rs268, rs1801177) (6)(7)(8)(11)(12)(13)(14) but contested by other authors (15)(16)(17). To the best of our knowledge, no data on the screening of such specific polymorphisms in the Saudi population have been reported.…”