Lipoprotein metabolism during normal pregnancy

Brizzi, Patrizia; Tonolo, Giancarlo; Esposito, Franca; Puddu, Leonardo; Dessole, Salvatore; Maioli, Mario; Milia, S

doi:10.1016/s0002-9378(99)70574-0

Cited by 195 publications

(154 citation statements)

References 19 publications

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“…When pregnancy progresses, specific changes in total cholesterol (TC), fractionated cholesterol and TG occur that leads to physiologically increased lipid levels towards the end of pregnancy (Sattar et al, 1997;Brizzi et al, 1999). It is thought that progressive increase in oestrogen levels during gestation induces most of these alterations in lipoprotein metabolism (Desoye et al, 1987), which suggests the necessity of these metabolic changes for pregnancy maintenance and foetal growth.…”

Section: Introductionmentioning

confidence: 99%

Ethnic differences in maternal total cholesterol and triglyceride levels during pregnancy: the contribution of demographics, behavioural factors and clinical characteristics

et al. 2011

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Background/Objectives: Lipid disturbances during pregnancy may lead to early onset of metabolic diseases in the offspring. However, there is little knowledge on ethnic differences in lipid levels during pregnancy. We evaluated ethnic differences in non-fasting total cholesterol (TC) and triglyceride (TG) levels during early gestation and the role of demographics, behavioural factors and clinical characteristics. Subjects/Methods: Non-diabetic pregnant women (N ¼ 3025) from the Amsterdam Born Children and their Development (ABCD) study. The studied ethnic groups were Dutch, Surinam-Hindustani, African-Caribbean, Turkish, Moroccan and Ghanaian. A multilingual questionnaire was used to gather information on maternal demographics, behavioural factors and clinical characteristics. Non-fasting TC, TG, percentage saturated fatty acid (%SFA) and percentage linoleic acid status (%LA) were assessed in blood samples collected at the first antenatal visit. Results: Ghanaian (À0.51 mmol/l), African-Caribbean (À0.19 mmol/l) and Moroccan (À0.15 mmol/l) women had significant lower TC levels compared with Dutch women. TG levels were lower in Ghanaian (log transformed À0.12 mmol/l) but significantly higher in Surinam-Hindustani (0.10 mmol/l) and Turkish women (0.07 mmol/l). Age, physical activity, pre-pregnancy body mass index (BMI), smoking, %SFA and %LA were independently related to TC and/or TG. However, only pre-pregnancy BMI could partly explain observed disparities. Furthermore, pre-pregnancy BMI had a relatively large effect on TG levels in Surinam-Hindustani and Turkish women. Conclusions: TC and TG levels differed between ethnic groups during early gestation. Only pre-pregnancy BMI partly explained the ethnic differences to a relevant degree. Reduction in BMI before pregnancy may improve lipid profile, especially in Surinam-Hindustani and Turkish women.

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Section: Introductionmentioning

confidence: 99%

Ethnic differences in maternal total cholesterol and triglyceride levels during pregnancy: the contribution of demographics, behavioural factors and clinical characteristics

et al. 2011

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“…34 Insulin resistance and relative hypoglycaemia results in lipolysis, allowing the pregnant mother to preferentially use fat for fuel, preserving the available glucose and amino acids for the foetus and minimising protein catabolism. The placenta allows transfer of glucose, amino acids and ketones to the foetus but is impermeable to large lipids.…”

Section: Glucose Metabolismmentioning

confidence: 99%

Physiological changes in pregnancy

Adamson¹,

Dhanjal²,

Nelson‐Piercy³

2011

OSH Heart Disease in Pregnancy

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Physiological changes occur in pregnancy to nurture the developing foetus and prepare the mother for labour and delivery. Some of these changes influence normal biochemical values while others may mimic symptoms of medical disease. It is important to differentiate between normal physiological changes and disease pathology. This review highlights the important changes that take place during normal pregnancy.

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“…Lipid metabolism alters during pregnancy [8]. The anabolic phase of early pregnancy encourages lipogenesis and fat storage in preparation for rapid fetal growth in late pregnancy [9].…”

Section: Introductionmentioning

confidence: 99%

Effect of Iron Supplementation on Plasma Lipid Levels in Pregnant Anemic Women

2016

IJSR

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Lipoprotein metabolism during normal pregnancy

Cited by 195 publications

References 19 publications

Ethnic differences in maternal total cholesterol and triglyceride levels during pregnancy: the contribution of demographics, behavioural factors and clinical characteristics

Ethnic differences in maternal total cholesterol and triglyceride levels during pregnancy: the contribution of demographics, behavioural factors and clinical characteristics

Physiological changes in pregnancy

Effect of Iron Supplementation on Plasma Lipid Levels in Pregnant Anemic Women

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