Lipoprotein Metabolism in Japanese Centenarians: Effects of Apolipoprotein E Polymorphism and Nutritional Status

Arai, Yasumichi; Hirose, Nobuyoshi; Nakazawa, S; Yamamura, Kazuo; Shimizu, Ken; Takayama, M.; Ebihara, Yoshinori; Osono, Yasunori; Homma, Satoki

doi:10.1046/j.1532-5415.2001.4911234.x

Cited by 39 publications

(26 citation statements)

References 60 publications

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“…They did not find any significant difference in lipid or apolipoprotein levels, however, the HDL2b level was increased, and the HDL3a level decreased in centenarians, compared to those in the controls (9). We have also demonstrated relatively higher levels of HDL2-C among 42 centenarians by ultracentrifugation (11). Recently, nuclear magnetic resonance (NMR) spectroscopy was efficiently applied for the quantification of lipoprotein particle size (14,15).…”

Section: Hdl Cholesterol and Its Subpopulations In Centenariansmentioning

confidence: 70%

“…However, results from centenarian studies have been conflicting. Some investigators have reported that centenarians showed a lipid profile similar to that of the middle-aged population (9), but others have demonstrated lower total and HDL cholesterol in centenarians (10,11). This discrepancy may be attributable to differences in sampling, and the nutritional and functional status of centenarians (this issue is also described in later paragraphs).…”

Section: Hdl Cholesterol and Its Subpopulations In Centenariansmentioning

confidence: 91%

“…Regarding the oldest elderly, however, we should consider the effects of age-related immune alteration or activation, which is ubiquitously observed in this exceptional population (35). A modest increase in CRP (11,26), IL-6 (11), and tumor nocrosis factor-α (TNF-α) (36) was demonstrated in centenarians even when they were in good health. Moreover, low-grade inflammatory activation is often associated with undernutrition indicated by hypoalbuminemia, poor health status, and chronic conditions such as atherosclerosis and dementia in the oldest elderly.…”

Section: Effects Of Nutritional Status and Inflammationmentioning

confidence: 99%

“…Log-transformed CRP and IL-6 were inversely correlated with HDL and apo A1. Multiple regression analysis was performed to evaluate independent contributions of these factors to the variance of lipid profiles, and indicated that the level of albumin was the strongest predictor of HDL-C in centenarians (11). However, in the oldest elderly, malnutrition often coexists with inflammatory activation, and the albumin level does not necessary reflect nutritional status.…”

Section: Effects Of Nutritional Status and Inflammationmentioning

confidence: 99%

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Aging and HDL Metabolism in Elderly People More Than 100 Years Old

Arai

Hirose

2004

J Atheroscler Thromb

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Epidemiological studies have enhanced the importance of high-density lipoprotein (HDL) as a risk factor for CAD, as well as disability and frailty in the oldest elderly. Therefore, HDL and molecules involved in HDL metabolism seem to be attractive candidates for longevity-promoting factors. A series of observational studies has demonstrated that the predominance of the larger, more lipid-rich HDL2 subclass is a reproducible phenotype among centenarians. This finding was recently evolved by nuclear magnetic resonance technology in quantification of lipoprotein particle size. However, results of investigations into the mechanisms underlying the lipoprotein profiles in the oldest elderly have been conflicting. Genetic variation in cholesteryl ester transfer protein (CETP), which is a carrier protein in reverse cholesterol transport, was demonstrated to have no association with longevity in one study, but to have positive impacts on large HDL particles and longevity in another. Regarding environmental factors, acute phase reactant and nutritional status are frequently associated with HDL-C levels in the oldest elderly, however, the causality of the association remains to be elucidated. Determination of the association between cognitive function and HDL in the oldest elderly is also a future task. To obtain further insight into the mechanistic roles of low HDL in the pathophysiology of geriatric syndrome, a much greater effort should be invested in this research field. J Atheroscler Thromb, 2004; 11: 246-252.

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Section: Hdl Cholesterol and Its Subpopulations In Centenariansmentioning

confidence: 70%

Section: Hdl Cholesterol and Its Subpopulations In Centenariansmentioning

confidence: 91%

Section: Effects Of Nutritional Status and Inflammationmentioning

confidence: 99%

Section: Effects Of Nutritional Status and Inflammationmentioning

confidence: 99%

See 2 more Smart Citations

Aging and HDL Metabolism in Elderly People More Than 100 Years Old

Arai

Hirose

2004

J Atheroscler Thromb

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“…This conclusion apparently clashes with the results of several previous epidemiological surveys, concluding that elevated plasma lipoprotein(a) concentration is a rather frequent finding in centenarians. [2][3][4][5][6] This apparent paradox has engaged the minds of several scientists for many years, trying to find a reliable bridge between the cardiovascular potency of elevated concentrations of this elusive lipoprotein and human longevity. [7][8] Apolipoprotein(a), which characterizes lipoprotein(a), is constituted by an inactive protease domain, a single copy of the plasminogen kringle V and multiple repeats of domains homologous to the plasminogen kringle IV.…”

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confidence: 99%