Lipoprotein Profile and High-Density Lipoproteins: Subfractions Distribution in Centenarians

Barbagallo, Carlo M.; Averna, Maurizio; Frada, G; Noto, Davide; Cavera, G.; Notarbartoló, A

doi:10.1159/000021992

Cited by 23 publications

(18 citation statements)

References 23 publications

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“…Barbagallo et al examined HDL subfractions using polyacrylamide gradient gels in 16 female centenarians and 32 healthy normolipidemic postmenopausal women. They did not find any significant difference in lipid or apolipoprotein levels, however, the HDL2b level was increased, and the HDL3a level decreased in centenarians, compared to those in the controls (9). We have also demonstrated relatively higher levels of HDL2-C among 42 centenarians by ultracentrifugation (11).…”

Section: Hdl Cholesterol and Its Subpopulations In Centenariansmentioning

confidence: 50%

“…However, results from centenarian studies have been conflicting. Some investigators have reported that centenarians showed a lipid profile similar to that of the middle-aged population (9), but others have demonstrated lower total and HDL cholesterol in centenarians (10,11). This discrepancy may be attributable to differences in sampling, and the nutritional and functional status of centenarians (this issue is also described in later paragraphs).…”

Section: Hdl Cholesterol and Its Subpopulations In Centenariansmentioning

confidence: 98%

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Aging and HDL Metabolism in Elderly People More Than 100 Years Old

Arai

Hirose

2004

J Atheroscler Thromb

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Epidemiological studies have enhanced the importance of high-density lipoprotein (HDL) as a risk factor for CAD, as well as disability and frailty in the oldest elderly. Therefore, HDL and molecules involved in HDL metabolism seem to be attractive candidates for longevity-promoting factors. A series of observational studies has demonstrated that the predominance of the larger, more lipid-rich HDL2 subclass is a reproducible phenotype among centenarians. This finding was recently evolved by nuclear magnetic resonance technology in quantification of lipoprotein particle size. However, results of investigations into the mechanisms underlying the lipoprotein profiles in the oldest elderly have been conflicting. Genetic variation in cholesteryl ester transfer protein (CETP), which is a carrier protein in reverse cholesterol transport, was demonstrated to have no association with longevity in one study, but to have positive impacts on large HDL particles and longevity in another. Regarding environmental factors, acute phase reactant and nutritional status are frequently associated with HDL-C levels in the oldest elderly, however, the causality of the association remains to be elucidated. Determination of the association between cognitive function and HDL in the oldest elderly is also a future task. To obtain further insight into the mechanistic roles of low HDL in the pathophysiology of geriatric syndrome, a much greater effort should be invested in this research field. J Atheroscler Thromb, 2004; 11: 246-252.

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Section: Hdl Cholesterol and Its Subpopulations In Centenariansmentioning

confidence: 50%

Section: Hdl Cholesterol and Its Subpopulations In Centenariansmentioning

confidence: 98%

Aging and HDL Metabolism in Elderly People More Than 100 Years Old

Arai

Hirose

2004

J Atheroscler Thromb

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“…66 Precedent data on the same sample demonstrated that, in spite of an independent and inverse association of total HDL-C levels with CAD in older women, no relation exists between any lipoprotein parameter and longevity in Italian centenarians. 67 Finally, healthy Italian centenarians had LDL-C significantly lower and HDL-C with an opposite trend compared to aged subjects, suggesting a less atherogenic plasma lipid and lipoprotein profile in centenarians than aged subjects. 68 Recently, low concentrations of TC and LDL-C, and a relative predominance of HDL2-C were found also in Japanese centenarians.…”

Section: Lipoproteins and Human Longevitymentioning

confidence: 88%

Lipoproteins, Vascular-Related Genetic Factors, and Human Longevity

Panza

D’Introno

Capurso

et al. 2007

Rejuvenation Research

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The relationships among lipoprotein metabolism, genetic vascular factors, vascular disease, and Alzheimer's disease suggest that the examination of centenarian populations in relation to certain genes or lipoprotein metabolism provide insights into human longevity. The findings on the higher frequency of the apolipoprotein E epsilon4 allele in middle-aged subjects than in centenarians were substantially confirmed. On the contrary, recent findings did not confirm previous data on increased prevalence of the high-risk angiotensin I converting enzyme D allele in French centenarians. The variability in the strength of association between angiotensin I converting enzyme polymorphism and longevity could be related to regional differences in angiotensin I converting enzyme D allele frequency in Europe recently showed, as also recently reported for apolipoprotein Eepsilon2 and epsilon4 allele in centenarians. Indeed some studies of lipoprotein profiles in centenarians have also had contradictory outcomes, with evidence of lower serum levels of high-density lipoprotein cholesterol, with higher high-density lipoprotein 2 cholesterol subfraction, larger high-density lipoprotein and low-density lipoprotein particle sizes, and higher lipoprotein(a) concentration in centenarians, which is apparently disadvantageous for human longevity. Elevated lipoprotein(a) serum levels, increasing the risk for cerebrovascular disease, may play a role in determining clinical Alzheimer's disease, but lipoprotein(a) elevation in centenarians, in the absence of other coronary artery disease risk factors, appears as a positive survival factor. In different populations, there are significant trends in the reduction of serum apolipoprotein E levels from apolipoprotein E epsilon2- to epsilon4-carriers and significant differences in serum apolipoprotein E levels with respect to age in epsilon4-carriers but only after adjustment for high-density lipoprotein cholesterol. While further studies are needed to confirm the possible role of apolipoprotein E concentration as putative longevity factor this paper provides an overview of many of the investigated vascular factors with respect to longevity.

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“…SAI was also significantly but moderately associated with interviewer-rated health, which provides support to its criterion validity. For biomarkers, SAI was related to greater high-density lipoprotein cholesterol which tends to be related to better cognitive capacity (Atzmon et al, 2002) and lower risks of coronary heart disease (Barbagallo et al, 1998). This pattern of associations provides support to the validity of SAI as an indicator of favorable health.…”

Section: Discussionmentioning

confidence: 64%