Liporotein-associated phospholipase-A2 can be a diagnostic marker inthe early stage diagnosis of acute mesenteric ischemia

Acar, Tarık; Koçak, Sedat; Cander, Başar; Ergin, Mehmet; Dikmetaş, Cesareddin

doi:10.3906/sag-1412-29

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…No new animal experiment was performed in the study. The serum samples obtained by Acar et al [11] were used for the present research. That study was approved by the Laboratory Animals Ethical Committee of Necmettin Erbakan University Experimental Medicine Research and Practice Center on January 20, 2012 (reg.…”

Section: Methodsmentioning

confidence: 99%

Role of Heparin Binding Protein (HBP) in the Diagnosis of Acute Mesenteric Ischemia

Koçak

Acar

Ertekin

et al. 2018

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Acute mesenteric ischemia (AMI) is associated with a high mortality rate, yet diagnostic difficulties persist. Although many biomarkers have been investigated for diagnostic purposes, as well as imaging methods, a sufficiently specific and sensitive marker has not been identified. This research was designed to examine whether heparin-binding protein (HBP), which has a role in the early phase of inflammation, could be useful in the diagnosis of AMI. METHODS: Serum samples obtained from a previously performed rabbit model of AMI were used in the study. HBP, C-reactive protein (CRP) and interleukin 6 (IL-6) levels were measured in blood samples obtained at baseline and 1, 3, and 6 hours from subjects that were separated into 3 groups: control, sham, and ischemia. The change in each marker over time and comparisons of the groups were evaluated statistically. RESULTS: A significant difference was not detected at the first hour in any of the studied markers. At the third hour, the CRP and IL-6 levels in the ischemia group indicated a significant increase in comparison with the control and sham groups (p<0.001). The HBP values showed a significant increase at the sixth hour in the ischemia group in comparison with the others (p<0.001). CONCLUSION: The HBP level demonstrated a slower increase in a rabbit model of AMI compared with CRP and IL-6. However, it still has the potential to become an early diagnostic biomarker. Diagnostic sensitivity and specificity should be evaluated in further clinical trials.

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Section: Methodsmentioning

confidence: 99%

Role of Heparin Binding Protein (HBP) in the Diagnosis of Acute Mesenteric Ischemia

Koçak

Acar

Ertekin

et al. 2018

Ulus Travma Acil Cerrahi Derg

Self Cite

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The Use of Multiple Cardiovascular Ischemia Markers in the Diagnosis of Acute Coronary Syndrome

图尔荪古丽

2023

ACM

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Liporotein-associated phospholipase-A2 can be a diagnostic marker inthe early stage diagnosis of acute mesenteric ischemia

Abstract: These findings showed the role of serum Lp-PLA2 and CRP levels in the early diagnosis of AMI. Thus, further studies are needed to describe the role of Lp-PLA2 in the early diagnosis of AMI.

Cited by 2 publications

References 19 publications

Role of Heparin Binding Protein (HBP) in the Diagnosis of Acute Mesenteric Ischemia

Role of Heparin Binding Protein (HBP) in the Diagnosis of Acute Mesenteric Ischemia

The Use of Multiple Cardiovascular Ischemia Markers in the Diagnosis of Acute Coronary Syndrome

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