Liposarcoma Arising in Uterine Lipoleiomyoma

McDonald, Anna G.; Cin, Paola Dal; Ganguly, Aniruddha; Campbell, Sharon; Imai, Yuki; Rosenberg, Andrew E.; Oliva, Esther

doi:10.1097/pas.0b013e31820414f7

Cited by 66 publications

(27 citation statements)

References 36 publications

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“…Many reported patients with liposarcoma have a neoplasm originating from the uterine cervix rather than the corpus. To the best of our knowledge, there are only 9 patients, including ours, reported in the English-language literature with a liposarcoma occurring in the uterine corpus( Bapat & Brustein, 1989 ; Sosnik et al, 2006 ; Hong et al, 2008 ; McDonald et al, 2011 ; Schoolmeester et al, 2016 ; Fadare & Khabele, 2011 ) ( Table 1 ). Patients with lipoleiomyosarcoma or mesenchymal malignant tumors having only a small part of liposarcomatous differentiation are excluded from this review.…”

Section: Discussionmentioning

confidence: 88%

Liposarcoma of the uterine corpus: A case report and literature review

Kiuchi

Hasegawa

Ochiai

et al. 2018

Gynecologic Oncology Reports

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Liposarcoma of the uterine corpus is extremely rare. We performed a laparotomy on a 55-year-old woman with the complaints of abdominal distension and genital bleeding who was found to have a uterine tumor, 17 × 16 cm in diameter. The preoperative diagnosis was a lipoma or lipoleiomyoma of the uterine corpus. However, pathological examination revealed proliferation of mature adipocytes and lipoblast-like atypical cells with small, weakly pleomorphic nuclei and foamy or vacuolated cytoplasm present within a fibrous septum. Immunohistochemistry showed that the tumor cells were focally positive for mouse double minute 2 homolog (MDM2). The final pathological diagnosis was a well-differentiated liposarcoma of International Federation of Gynecology and Obstetrics (FIGO) stage IB (pT1bNxM0). On magnetic resonance imaging (MRI), T1 -weighted and fat-saturated images showed high and low intensity in the tumor, respectively, suggesting that this tumor contained a fat component. The septum inside the tumor had a contrast enhancement on T1-weighted, gadolinium-enhanced imaging. The septum was nonuniformly thickened and partially nodular. In hindsight, these findings may have suggested a well-differentiated liposarcoma in the uterine corpus rather than a lipoma or lipoleiomyoma. Clinicians should be aware of the possibility of a liposarcoma of the uterine corpus when a neoplasm contains adipose tissue and a nonuniformly thickened or partially nodular septum on MRI.

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Section: Discussionmentioning

confidence: 88%

Liposarcoma of the uterine corpus: A case report and literature review

Kiuchi

Hasegawa

Ochiai

et al. 2018

Gynecologic Oncology Reports

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“…However, lipoleiomyosarcomas arising in uterine lipoleiomyomas and intravenous lipoleiomyomatosis have been rarely reported. 18 19 20 Therefore, patients may be followed-up with routine gynecological examinations. 8 Recurrence of some benign tumors after hysterectomy has been reported.…”

Section: Discussionmentioning

confidence: 99%

Uterine Lipoleiomyoma in Peri or Postmenopausal Women

Cho

Han

et al. 2015

J Menopausal Med

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Lipoleiomyoma is an uncommon neoplasm of the uterus, composed of smooth muscles intermixed with mature adipocytes. These tumors are considered a benign variant of uterine leiomyomas. Herein, we report six cases of lipoleiomyoma experienced in our institution from January 2005 to March 2015. The patients ranged in age from 45 to 70 years; the etiology may be related to estrogen deficiency occurring after menopausal transition. Except for one lipoleiomyoma in the broad ligament, all others were found in the uterine corpus. The presenting symptoms were nonspecific, and most cases were incidentally diagnosed during surgery for other reasons. We performed preoperative imaging studies, including abdominal and pelvic computed tomography and magnetic resonance imaging. Preoperatively, four patients were diagnosed as having a pelvic mass and one patient was diagnosed as having a right ovarian mature teratoma. In one case, we found a gynecologic malignancy (cervical cancer 1A1). Histologically, there was no gross or microscopic contiguity between the lipoleiomyoma and the malignancy. Lipoleiomyomas seem to have a benign clinical course. In our study, there were no recurrences of or deaths attributed to the lipoleiomyomas during a mean follow-up period of 16.17 ± 23.80 months.

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“…In the present case, although the uterine tumor was depicted as a poorly demarcated diffuse lesion within the myometrium on MRI, a lipomatous component indicative of a benign lipomatous tumor such as a lipoleiomyoma [ 11 – 13 ], angiomyolipoma [ 14 ], or pure lipoma [ 15 ] was also detected within the tumor. Although liposarcoma, which consists of less-differentiated fat cells that have undergone sarcomatous change, can be included in the differential diagnosis, it is exceptionally rare, with only 13 cases having been reported in conjunction with intravenous leiomyosarcomatosis [ 16 ]. In this respect, MRI may be able to provide precise information about the characteristics of the uterine tumor.…”

Section: Discussionmentioning

confidence: 99%

Uterine Intravenous Leiomyomatosis with Cardiac Extension: Radiologic Assessment with Surgical and Pathologic Correlation

Nakai

Maeda

Yamamoto

et al. 2015

Case Reports in Obstetrics and Gynecology

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We present the computed tomography (CT) and magnetic resonance (MR) imaging findings of a 71-year-old woman with a cardiac extension of intravenous leiomyoma (IVL) that arose from the uterus, extended to the inferior vena cava (IVC), and reached the right ventricle through the right ovarian vein. Radiologic-pathologic correlation showed that the intravascular cord-like mass originating from the IVC and extending to the right ventricle was composed of degenerated smooth muscle cells with a number of large vessels that were regarded as arteries; moreover, the arteries within the cord-like mass appeared to be looping internally. Given the disappearance of the right ovarian venous wall around the IVL pathologically, extracting the tumor from the ovarian vein during an operation is considered to be impossible retrospectively. Also it was difficult to identify even the intravenous extension of the uterine leiomyoma histopathologically. Therefore, contrast-enhanced CT, in particular arterial phase imaging, provided important information that revealed the mass, range, and path of the lesion, ensuring that an appropriate operative plan could be drawn up and the tumor completely excised.

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Liposarcoma Arising in Uterine Lipoleiomyoma

Cited by 66 publications

References 36 publications

Liposarcoma of the uterine corpus: A case report and literature review

Liposarcoma of the uterine corpus: A case report and literature review

Uterine Lipoleiomyoma in Peri or Postmenopausal Women

Uterine Intravenous Leiomyomatosis with Cardiac Extension: Radiologic Assessment with Surgical and Pathologic Correlation

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