Liposarcoma of the retropharyngeal space

Nguyen, Jacqueline; Manji, Jamil; Vodanovich, Domagoj; Hart, Cameron; Corry, June; Lyons, Bernard; Dixon, Benjamin J.

doi:10.1111/ans.17754

Cited by 1 publication

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Surgical intervention is the primary treatment for retropharyngeal liposarcomas and surgical approach depends on tumor size and extension into neighboring structures. Literature reports cases of retropharyngeal liposarcomas that have been resected via an open anterior neck dissection, cervical or transoral approach [ 3 - 9 ]. In our case, the surgical approach involved a series of meticulous procedures aimed at ensuring optimal management and preservation of vital structures.…”

Section: Discussionmentioning

confidence: 99%

A Case Report of a 17 cm Retropharyngeal Well-Differentiated Liposarcoma With Bilateral Neck Extension

Melero-Pardo,

Pimentel-Soler,

Rullán-Marín

et al. 2024

Cureus

View full text Add to dashboard Cite

Liposarcomas, malignant adipocytic tumors, primarily manifest in the lower extremities and retroperitoneum, with a strikingly low incidence in the head and neck region. Symptomatology typically remains absent until the tumor attains significant size, leading to cosmetic concerns or compression-related complications. This report presents a unique case of well-differentiated retropharyngeal liposarcoma in an 81-year-old male, emphasizing diagnostic challenges, management strategies, and the crucial role of Mouse double minute 2 (MDM2) fluorescence in situ hybridization (FISH) analysis in confirmation.The patient exhibited dysphagia attributed to a retropharyngeal mass, prompting suspicion of malignancy. Diagnostic assessments, including flexible laryngoscopy and percutaneous tru-cut biopsy, highlighted unique features such as atypical nuclear features in adipocytes. MDM2 FISH analysis definitively confirmed the diagnosis by detecting MDM2 gene amplification.The rarity of retropharyngeal liposarcomas complicates diagnosis, often leading to confusion with benign lesions. Surgical excision, the mainstay of treatment, varies based on tumor size and extension. In this case, a left neck dissection via a hockey stick incision successfully resected a 17 cm well-differentiated liposarcoma. Pathologic analysis revealed focal involvement of resection margins, with no complications or vocal cord damage.In conclusion, retropharyngeal liposarcomas pose diagnostic challenges, warranting reliance on MDM2 FISH analysis for accurate confirmation. Early surgical intervention, guided by tumor size and extension, is paramount for optimal outcomes in managing these rare tumors. This case underscores the significance of a detailed surgical approach in achieving successful outcomes for retropharyngeal liposarcomas.

show abstract

Section: Discussionmentioning

confidence: 99%