260oft tissue sarcomas are rare tumors accounting for 0.7% of all adult malignancies.1 Liposarcomas develop from mature adipose tissue cells (lipoblasts) or more frequently from primitive mesenchymal cells. 2,3 Liposarcomas are the second most common soft tissue sarcomas in adults (14-18%).4 Based on pathologic evaluation, liposarcomas are classified as well-differentiated, poorly-differentiated, myxoid, pleomorphic, and mixed types. 5 The most common type of liposarcoma is the myxoid liposarcoma; it involves the lower extremity, thigh or retroperitoneum and is sometimes multifocal.6 Liposarcomas have five subtypes with prognoses directly related with histopathologic features. Liposarcomas are located on the head and neck regions at a rate of approximately 1%.7,8 Here we present a patient with a myxoid liposarcoma on the thigh with metastasis to the scalp with a review of the literature.