Liposarcoma retroperitoneal gigante

Abstract

El liposarcoma es un tumor maligno de origen mesodérmico derivado del tejido adiposo, que representa la variedad más frecuente dentro de los sarcomas de partes blandas del retroperitoneo aunque globalmente sólo supone el 0,1% de todas las neoplasias. Su crecimiento es lento y silente siendo su síntoma más frecuente la abdominalgia difusa inespecífica y su signo el aumento del perí-metro abdominal. El tratamiento es la cirugía radical siendo básica su resección completa para el control local de la enfermedad. Su tendencia a la afectación multiorgánica y el gran tamaño que alcanzan en su localización retroperitoneal, puede dificultar este objetivo precisando en un alto porcentaje la resección de diferentes órganos de la economía.Presentamos un caso de liposarcoma retroperitoneal gigante derecho que se manifestó por dolor continuo en el hemiabdomen izquierdo por el desplazamiento visceral, que englobaba el riñón derecho elongando su pedículo vascular y anulando su función.La alta probabilidad de persistencia de enfermedad microscópica residual obliga a un estricto seguimiento del paciente indicándose en ocasiones el tratamiento complementario con radioterapia.PALABRAS CLAVE: Tumor retroperitoneal. Liposarcoma. Tratamiento. ABSTRACTGIANT RETROPERITONEAL LIPOSARCOMA Liposarcoma is a malignant tumor that have an embryologic origin from mesodermal tissue depending on fatty tissue. Although liposarcoma is only 0.1% of all human neoplasms is the most common histology subtype of retroperitoneal soft tissue sarcomas.This tumor grows slowly. Diffuse abdominal pain is its most frequent symptom and abdominal mass is the most common sign. Aggressive surgical treatment is basic to get a complete resection and a local disease control. This objetive is difficult because of the large tumor size it gets in the retroperitoneal location and the multiorgan involvement that require the resection of a high percentage of contiguous organs.We report a case of a giant retroperitoneal liposarcoma presenting like continuous left hemiabdominal pain because the visceral compression. The right kidney was involved and suffering from renal vessels enlargement without renal function.There is a high probability of microscopic residual disease and a good follow-up of the patients is necessary as well as an adjuvant radiation therapy in some cases.

Long-Term Recurrence of Retroperitoneal Dedifferentiated Liposarcoma After a Complete Surgical Resection: A Report of a Rare Phenomenon

“…The gold standard of care for retroperitoneal liposarcoma is aggressive surgical management, however, radiation or chemotherapy are also possible treatment options [ 4 ]. In addition to the traditional treatment options, promising early clinical trial results with the use of cyclin-dependent kinase 4 (CDK4) inhibitor palbociclib have shown to help inhibit the growth of tumor cells, and have resulted in improved clinical outcomes for both WDL and DDL [ 5 ].…”