Liposclerosing myxofibrous tumor: A series of 9 cases and review of the literature

Regado, Eduardo Rinaldi; Garcia, Pedro Braga Linhares; Caruso, Anabela Cunha; Almeida, Ana Luzia Brito de; Aymoré, Ierecê Lins; Meohas, Walter; Aguiar, Diego Pinheiro

doi:10.1016/j.jor.2016.03.003

Cited by 12 publications

(10 citation statements)

References 7 publications

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“…Liposclerosing myxofibrous tumors (LSMFT) are rare, benign fibro-osseous lesions commonly occurring in the femoral intertrochanteric region. It can also be seen occasionally at other sites such as humerus, rib, iliac bone (Kransdorf et al, 1999;Ragsdale, 1993), tibia (Choi et al, 2005;Regado et al, 2016) and skull (Ploof et al, 2018). The reason for this strong predilection is unknown.…”

Section: Discussionmentioning

confidence: 99%

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Bone SPECT/CT imaging of a liposclerosing myxofibroid tumor in an unexpected localization

Kampen¹,

Antunovic

Luebke

et al. 2018

European J Hybrid Imaging

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Background: The combination of both functional and morphological information using three-phase bone scintigraphy and tomographic imaging with single photon emission tomography/computed tomography (SPECT/CT) allows precise characterization of most bone lesions. The hybrid imaging is most useful when conventional imaging is equivocal or contraindicated (e.g magnetic resonance imaging (MRI). Case presentation: A 69-year old, male patient with moderate pain in his posterior pelvic region was diagnosed with an unclear tumor of the iliac bone. Conventional radiographs, computed tomography (CT), and MRI imaging were inconclusive to confirm or refute a malignant process. There was no abnormal hyperperfusion on the early images. On the delayed images, moderately increased osteoblastic activity was noted, and the provisional diagnosis was in favor of a benign process. Histopathology confirmed a benign liposclerosing myxofibrous tumor located in the left iliac bone. Conclusion: Bone scan SPECT/CT might (a) help in classifying bone lesions by combining their metabolic and morphological (e.g CT) characteristics and (b), might help in discriminating benign and malignant tumors.

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Section: Discussionmentioning

confidence: 99%

“…The reason for this strong predilection is unknown. LSMFT commonly occurs in the 4th decade and affects both men and women equally (Regado et al, 2016). The most frequent presenting symptoms include mild bone pain or occasionally pathological fracture (Dattilo & McCarthy, 2012).…”

Section: Discussionmentioning

confidence: 99%

Bone SPECT/CT imaging of a liposclerosing myxofibroid tumor in an unexpected localization

Kampen¹,

Antunovic

Luebke

et al. 2018

European J Hybrid Imaging

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“…Recently, Regado et al studied the radiological, clinical and pathological features of nine cases of LSMFT. 7 In their cases, the femur was the most affected bone (77.7%), with six cases (66.6%) in the proximal metaphysis and one case (11.1%) in the distal metaphysis. One case (11.1%) of LSMFT was reported in distal tibia and the other (11.1%) in the iliac bone.…”

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confidence: 98%

“…2e5 Only a few cases of spontaneous 'malignant transformation' (MT) of LSMFT have been reported. 1,2,6,7 To the best of our knowledge, this is the first reported case of MT in LSMFT in association with presumed polyostotic FD.This study was approved by the institutional review board (IRB) of our hospital (No. UC18SESI0111).…”

mentioning

confidence: 99%

“…4 Some previous reports have stated that LSMFT shows a higher risk of MT (10e16%) than FD. 1,2,6,7,11 It has been suggested that the increased MT of LSMFT than of FD is related to involutional and ischaemic changes from an area of ischaemic ossification or progressive in situ atypism of altered lipomatous elements. 11 Reported entities of MT include osteosarcoma, undifferentiated pleomorphic sarcoma [UPS, previously called malignant fibrous histiocytoma (MFH)], malignant fibroxanthoma, and high-grade spindle cell tumour.…”

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confidence: 99%

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Malignant transformation of liposclerosing myxofibrous tumour

Bahk

Seo

2021

Pathology

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Malignant transformation of liposclerosing myxofibrous tumourSir, Liposclerosing myxofibrous tumour (LSMFT) is a benign fibro-osseous bone lesion that was first described by Ragsdale and Sweet in 1986. 1 LSMFT is a comparatively rare bone lesion, and it is thought to be related to fibrous dysplasia (FD) because of similarities in their histological and radiographic features. A recent molecular study provided additional evidence for the relationship between LSMFT and FD: an activating point mutation in the alpha subunit of a G protein (GNAS) was identified in some LSMFT samples, and the same mutation is present in nearly all cases of polyostotic and monostotic FD. 2e5 Only a few cases of spontaneous 'malignant transformation' (MT) of LSMFT have been reported. 1,2,6,7 To the best of our knowledge, this is the first reported case of MT in LSMFT in association with presumed polyostotic FD.This study was approved by the institutional review board (IRB) of our hospital (No. UC18SESI0111). Informed consent was obtained from the patient for publication of this case.A 75-year-old female patient with left knee joint pain was referred to our hospital. Plain radiographs of both knees revealed osteoarthritis of the left knee joint (Fig. 1A). In addition, multiple osteolytic and sclerotic lesions were incidentally found in the right proximal tibia and distal femur (Fig. 1A,B, arrows). These lesions demonstrated

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