Liposoluble portion of the red alga Pyropia yezoensis protects alcohol induced liver injury in mice

Lee, Ji-Hyeok; Ahn, Ginne; Ko, Ju-Young; Kang, Ning; Jung, Kyungsook; Han, Eui-Jeong; Kim, Gwang Hoon; Kim, Hee Jeong; Choi, Cheol Soo; Jeon, You‐Jin

doi:10.4490/algae.2021.36.4.28

Cited by 3 publications

(2 citation statements)

References 45 publications

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“…The Bangiales (Rhodophyta) contains some of the commercially most important red algae that have been used for millennia and support multi-million dollars industries mainly in Asia (Kim et al 2014, Badis et al 2020, Dai et al 2020, Lee et al 2021. The order contains two morphological types in the gametophytes: a group consisting mostly of monostromatic blades, and a filamentous group.…”

Section: Introductionmentioning

confidence: 99%

Splitting blades: why genera need to be more carefully defined; the case for <italic>Pyropia</italic> (Bangiales, Rhodophyta)

Zuccarello¹,

Wen²,

Kim³

2022

Algae

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The trend in naming genera based almost exclusively on molecular data, and not on morphological diagnostic characters, is increasing. In bifurcating phylogenetic trees generic cut-offs are arbitrary, but at the bare minimum nomenclatural changes should be supported by multiple phylogenetic methodologies using appropriate models for all the various gene partitions, strong support with all branch support methods, and should also result in adding to our knowledge of the interrelationships of taxa. We believe that a recent taxonomic treatment of the genus Pyropia (Yang et al. 2020) into several genera is unwarranted. We reanalysed the data presented in the recent article, using additional phylogenetic methods. Our results show that many of the newly established genera are not well supported by all methods, and the new circumscription of the genus Pyropia renders it unsupported. We also tested additional outgroups, which were previously suggested as sister to Pyropia, but this did not substantially change our conclusions. These generic nomenclatural changes of the previously strongly supported genus Pyropia, do not shed light on the evolution of this group and have serious consequences in these commercially important algae, that are also governed by a plethora of regulation and by-laws that now need to be amended. We suggest that the over-splitting of groups based only on poorly produced and modestly supported phylogenies should not be accepted and that the genus Pyropia sensu Sutherland et al. (2011) be restored.

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Section: Introductionmentioning

confidence: 99%

Splitting blades: why genera need to be more carefully defined; the case for <italic>Pyropia</italic> (Bangiales, Rhodophyta)

Zuccarello¹,

Wen²,

Kim³

2022

Algae

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“…Treatment with UD seed oil alone decreased the elevated level of MDA in the blood, and increased antioxidants such as glutathione (GSH), ceruloplasmin, vitamin E, vitamin C, beta-carotene and retinol in the serum of CCl 4 -treated rats [ 83 ]. It was suggested that the properties of UD observed in the study, such as the increase in antioxidants and the decrease in lipid peroxidation may be utilized in hepatoprotective therapies [ 83 , 84 , 85 ].…”

Section: Antioxidant Potential Of Udmentioning

confidence: 99%

Antioxidant Activity of Urtica dioica: An Important Property Contributing to Multiple Biological Activities

Jaiswal

Lee

2022

Antioxidants

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Urtica dioica (UD) is a multi-functional plant known to be used as both food and medicine from ancient times. The plant has the potential to be used as a fertilizer and for biological pest control. It is also used in textile and related industries for its quality fibers. In the recent past, the plant has received great attention for its numerous important biological activities and food applications. The antioxidant activity of UD is the crucial factor supporting its important biological activities, such as anticancer, antidiabetic and anti-inflammatory properties. The antioxidant activity of UD is also found to be protective in different organs, including the brain, liver, lungs, kidney, ovary, and uterus, and may also be protective against diseases associated with these organs. Few clinical studies have endorsed the antioxidant potential of UD in patients. The current work is an attempt to comprehensively compile and discuss the antioxidant activity of UD from in vitro, in vivo and human studies. The insights of the current study would be helpful in getting a panoramic view of the antioxidant potential of UD, and provide direction for optimizing and developing it for therapeutic applications against important diseases and conditions in the near future.

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Antiviral effect of fucoxanthin obtained from Sargassum siliquastrum (Fucales, Phaeophyceae) against severe acute respiratory syndrome coronavirus 2

Kang,

Heo,

Kim

et al. 2023

Algae

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Human coronavirus diseases, particularly severe acute respiratory syndrome coronavirus 2, still remain a persistent public health issue, and many recent studies are focusing on the quest for new leads against coronaviruses. To contribute to this growing pool of knowledge and explore the available marine natural products against coronaviruses, this study investigated the antiviral effects of fucoxanthin isolated from Sargassum siliquastrum—a brown alga found on Jeju Island, South Korea. The antiviral effects of fucoxanthin were confirmed in severe acute respiratory syndrome coronavirus 2-infected Vero cells, and its structural characteristics were verified in silico using molecular docking and molecular dynamic simulations and in vitro colorimetric method. Fucoxanthin inhibited the infection in a concentration-dependent manner, without showing cytotoxicity. Molecular docking simulations revealed that fucoxanthin binds to the angiotensinconverting enzyme 2-spike protein (binding energy -318.306 kcal mol<sup>-1</sup>) and main protease (binding energy -205.118 kcal mol<sup>-1</sup>). Moreover, molecular dynamic simulations showed that fucoxanthin remains docked to angiotensin-converting enzyme 2-spike protein for 20 ns, whereas it breaks away from main protease after 3 ns. Also, the in silico prediction of the fucoxanthin was verified through the in vitro colorimetric method by inhibiting the binding between angiotensinconverting enzyme 2 and spike protein in a concentration-dependent manner. These results indicate that fucoxanthin exhibits antiviral effects against severe acute respiratory syndrome coronavirus 2 by blocking the entry of the virus. Therefore, fucoxanthin from S. siliquastrum can be a potential candidate for treating coronavirus infection.

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Liposoluble portion of the red alga Pyropia yezoensis protects alcohol induced liver injury in mice

Cited by 3 publications

References 45 publications

Splitting blades: why genera need to be more carefully defined; the case for <italic>Pyropia</italic> (Bangiales, Rhodophyta)

Splitting blades: why genera need to be more carefully defined; the case for <italic>Pyropia</italic> (Bangiales, Rhodophyta)

Antioxidant Activity of Urtica dioica: An Important Property Contributing to Multiple Biological Activities

Antiviral effect of fucoxanthin obtained from Sargassum siliquastrum (Fucales, Phaeophyceae) against severe acute respiratory syndrome coronavirus 2

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