Liposomal co-encapsulation of a novel gemini lipopeptide and a CpG-ODN induces a strong Th1 response with the co-activation of a Th2/Th17 profile and high antibody levels

Reidel, Ivana Gabriela; Curti, Cecilia Carol; Dorémus, Léa; Béré, Emile; Delwail, Adriana; Russi, Romina Cecilia; Lecron, Jean-Claude; Morel, Franck; García, María Inés; Müller, Diana María; Jégou, Jean-François; Veaute, Carolina Melania

doi:10.1016/j.vaccine.2024.02.011

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A methamphetamine vaccine using short monoamine and diamine peptide linkers and poly-mannose

Hossain,

Davidson,

Feehan

et al. 2024

Bioorganic & Medicinal Chemistry

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A methamphetamine vaccine using short monoamine and diamine peptide linkers and poly-mannose

Hossain,

Davidson,

Feehan

et al. 2024

Bioorganic & Medicinal Chemistry

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Efficient Immune Shield: Biomimetic Nanovaccine of Acinetobacter Baumannii Recombinant Outer Membrane Protein W

Zhu,

Liang,

Yang

et al. 2024

Preprint

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Background The development of vaccines is an effective and safe strategy to combat multidrug-resistant (MDR) Acinetobacter baumannii (A. baumannii) infections. This study aimed to prepare a DC-targeting multiepitope peptide biomimetic nanovaccine and evaluate its immune response and protective effect in mice. Results The B-cell and T-cell epitopes of the OmpW protein from A. baumannii were predicted and screened using bioinformatics methods and identified by immunological means. The selected dominant epitopes were conjugated in series with 6-aminocaproic acid, and a multiepitope peptide, rOmpW, was chemically synthesized. Then, rOmpW was encapsulated with polylactic-co-glycolic acid (PLGA) and a neutrophil membrane (NM), and the surface was modified with DC-targeting peptide (DCpep) to construct the biomimetic nanovaccine DCpep-NM-PLGA-rOmpW. This biomimetic nanovaccinecan induce strong Th1 and Th17 cellular immune responses and humoral immunity. The biomimetic nanovaccine produced efficient immunological protection in an acute lethal pneumonia model of A. baumannii. Conclusions Our results indicate the potential translational value of this biomimetic nanovaccinefor preventing A.baumannii infection.

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Liposomal co-encapsulation of a novel gemini lipopeptide and a CpG-ODN induces a strong Th1 response with the co-activation of a Th2/Th17 profile and high antibody levels

Cited by 2 publications

References 48 publications

A methamphetamine vaccine using short monoamine and diamine peptide linkers and poly-mannose

A methamphetamine vaccine using short monoamine and diamine peptide linkers and poly-mannose

Efficient Immune Shield: Biomimetic Nanovaccine of Acinetobacter Baumannii Recombinant Outer Membrane Protein W

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