Liposomal curcumin and its application in cancer

Abstract

Curcumin (CUR) is a yellow polyphenolic compound derived from the plant turmeric. It is widely used to treat many types of diseases, including cancers such as those of lung, cervices, prostate, breast, bone and liver. However, its effectiveness has been limited due to poor aqueous solubility, low bioavailability and rapid metabolism and systemic elimination. To solve these problems, researchers have tried to explore novel drug delivery systems such as liposomes, solid dispersion, microemulsion, micelles, nanogels and dendrimers. Among these, liposomes have been the most extensively studied. Liposomal CUR formulation has greater growth inhibitory and pro-apoptotic effects on cancer cells. This review mainly focuses on the preparation of liposomes containing CUR and its use in cancer therapy.

Water Soluble Octenyl Succinylated Cassava Starch‐Curcumin Nanoformulation With Enhanced Bioavailability and Anticancer Potential

“…Wet grinding process could partly break down curcumin crystals also and turn them into the amorphous state. [8] Therefore, in the present study, the crystallinity of starch as well as curcumin had been affected by the grinding process and the XRD pattern of OSA starch loaded nanocurcumin was mostly amorphous. It was also reported that the solubility of curcumin in water was due to the www.advancedsciencenews.com www.starch-journal.com change of curcumin from its crystalline form to amorphous form when curcumin was wet milled with OSA starch.…”

“…Amylopectin molecules are more susceptible to degradation because of their rigid double helical crystallites than the more flexible amylose molecules. Wet grinding process could partly break down curcumin crystals also and turn them into the amorphous state . Therefore, in the present study, the crystallinity of starch as well as curcumin had been affected by the grinding process and the XRD pattern of OSA starch loaded nanocurcumin was mostly amorphous.…”

“…However, low bioavailability due to insolubility in water is a major problem of curcumin which limits its application in pharmaceutical products. Different approaches to increase the bioavailability of curcumin includes loading on various materials such as nanoparticles, liposomes, phospholipid complexes, micelles, or converting curcumin to its nanoform . A wet milling process of curcumin with a commercially available hydrophobically modified starch was reported for the preparation of curcumin nanodispersion with enhanced solubility and in vitro anti‐cancer bioactivity .…”

“…Different approaches to increase the bioavailability of curcumin includes loading on various materials such as nanoparticles, liposomes, phospholipid complexes, micelles, or converting curcumin to its nanoform. [7][8][9] A wet milling process of curcumin with a commercially available hydrophobically modified starch was reported for the preparation of curcumin nanodispersion with enhanced solubility and in vitro anti-cancer bioactivity. [10] Giat et al [11] reported preparation of curcumin nanoformulation by wet milling process by using glass balls.…”

Alternative Therapeutic Approach for Cartilage Repair

“…Besides, it downregulates the expression of differentiated embryochondrocyte expressed gene 1 (DEC1) and hypoxia-inducible factor-1-α (HIF-1α) [33][34][35][36].…”