Liposomal doxorubicin-loaded chitosan microspheres capable of controlling release of doxorubicin for anti-cancer chemoembolization: in vitro characteristics

Kim, Hyeong-Min; Lee, Ga-Hyeon; Kuh, Hyo-Jeong; Kwak, Byung Kook; Lee, Jaehwi

doi:10.1016/s1773-2247(13)50042-6

Cited by 6 publications

(3 citation statements)

References 20 publications

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“…Typically, drug loading onto microbeads was performed through an ion exchange reaction by immersing the beads in the drug solution for more than 30 min. Another difficulty encountered was controlling the drug release from microbeads as it depended on the exchange of drugs with endogenous ions in the blood vessels Table shows several commercial products for DEB-TACE.…”

Section: Non-radioactive Microspheresmentioning

confidence: 99%

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The Use of Microspheres for Cancer Embolization Therapy: Recent Advancements and Prospective

Nuzulia,

Mart,

Ahmed

et al. 2024

ACS Biomater. Sci. Eng.

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Embolization therapy involving biomaterials has improved the therapeutic strategy for most liver cancer treatments. Developing biomaterials as embolic agents has significantly improved patients' survival rates. Various embolic agents are present in liquid agents, foam, particulates, and particles. Some of the most applied embolic agents are microparticles, such as microspheres (3D micrometer-sized spherical particles). Microspheres with added functionalities are currently being developed for effective therapeutic embolization. Their excellent properties of high surface area and capacity for being loaded with radionuclides and alternate active or therapeutic agents provide an additional advantage to overcome limitations from traditional cancer treatments. Microspheres (nonradioactive and radioactive) have been widely used and explored for localized cancer treatment. Non-radioactive microspheres exhibit improved clinical performance as drug delivery vehicles in chemotherapy due to their controlled and sustained drug release to the target site. They offer better flow properties and are beneficial for the ease of delivery via injection procedures. In addition, radioactive microspheres have also been exploited for use as an embolic platform in internal radiotherapy as an alternative to cancer treatment. This short review summarizes the progressive development of non-radioactive and radioactive embolic microspheres, emphasizing material characteristics. The use of embolic microspheres for various modalities of therapeutic arterial embolization and their impact on therapeutic performance are also discussed.

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Section: Non-radioactive Microspheresmentioning

confidence: 99%

“…Another difficulty encountered was controlling the drug release from microbeads as it depended on the exchange of drugs with endogenous ions in the blood vessels. 78 Table 3 shows several commercial products for DEB-TACE.…”

Section: Conventional Tace (C-tace)mentioning

confidence: 99%

The Use of Microspheres for Cancer Embolization Therapy: Recent Advancements and Prospective

Nuzulia,

Mart,

Ahmed

et al. 2024

ACS Biomater. Sci. Eng.

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“…Tumor size was decreased by about one-third of the initial size in CMs treated groups, whereas other groups treated with normal saline, DX solution, and blank chitosan microspheres showed increased tumor size. Kim et al [55] conducted another study to improve conventional CMs for chemoembolization. They noticed that the drug loading prior to clinical use was time consuming and the drug release was instable.…”

Section: Diversity Of Chitosan-based Local Drug Deliverymentioning

confidence: 99%

Chitosan-Based Multifunctional Platforms for Local Delivery of Therapeutics

et al. 2017

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Chitosan has been widely used as a key biomaterial for the development of drug delivery systems intended to be administered via oral and parenteral routes. In particular, chitosan-based microparticles are the most frequently employed delivery system, along with specialized systems such as hydrogels, nanoparticles and thin films. Based on the progress made in chitosan-based drug delivery systems, the usefulness of chitosan has further expanded to anti-cancer chemoembolization, tissue engineering, and stem cell research. For instance, chitosan has been used to develop embolic materials designed to efficiently occlude the blood vessels by which the oxygen and nutrients are supplied. Indeed, it has been reported to be a promising embolic material. For better anti-cancer effect, embolic materials that can locally release anti-cancer drugs were proposed. In addition, a complex of radioactive materials and chitosan to be locally injected into the liver has been investigated as an efficient therapeutic tool for hepatocellular carcinoma. In line with this, a number of attempts have been explored to use chitosan-based carriers for the delivery of various agents, especially to the site of interest. Thus, in this work, studies where chitosan-based drug delivery systems have successfully been used for local delivery will be presented along with future perspectives.

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Enzyme-responsive destabilization of stabilized plasmid-lipid nanoparticles as an efficient gene delivery

Song

Lee

et al. 2016

European Journal of Pharmaceutical Sciences

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Liposomal doxorubicin-loaded chitosan microspheres capable of controlling release of doxorubicin for anti-cancer chemoembolization: in vitro characteristics

Cited by 6 publications

References 20 publications

The Use of Microspheres for Cancer Embolization Therapy: Recent Advancements and Prospective

The Use of Microspheres for Cancer Embolization Therapy: Recent Advancements and Prospective

Chitosan-Based Multifunctional Platforms for Local Delivery of Therapeutics

Enzyme-responsive destabilization of stabilized plasmid-lipid nanoparticles as an efficient gene delivery

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