Liposomal-encapsulated Ascorbic Acid: Influence on Vitamin C Bioavailability and Capacity to Protect against Ischemia–Reperfusion Injury

Abstract

Intravenous administration of vitamin C has been shown to decrease oxidative stress and, in some instances, improve physiological function in adult humans. Oral vitamin C administration is typically less effective than intravenous, due in part to inferior vitamin C bioavailability. The purpose of this study was to determine the efficacy of oral delivery of vitamin C encapsulated in liposomes. On 4 separate randomly ordered occasions, 11 men and women were administered an oral placebo, or 4 g of vitamin C via oral, oral liposomal, or intravenous delivery. The data indicate that oral delivery of 4 g of vitamin C encapsulated in liposomes (1) produces circulating concentrations of vitamin C that are greater than unencapsulated oral but less than intravenous administration and (2) provides protection from ischemia–reperfusion-mediated oxidative stress that is similar to the protection provided by unencapsulated oral and intravenous administrations.

Witamina C w leczeniu nowotworów i profilaktyce chorób niezakaźnych

“…Standardowo zalecana suplementacja witaminą C to dawka od 100 do 1000 mg/dzień w postaci tabletek powlekanych [6,49]. Przy zaawansowanych postaciach szkorbutu polecana jest forma liposomalna, charakteryzująca się zwiększoną wchłanialnością [48]. Przy stanach zapalnych pochwy zaleca się suplementację dopochwową w dawce 250 mg/dzień [49].…”

Design and development of vitamin C-encapsulated proliposome with improved in-vitro and ex-vivo antioxidant efficacy

“…The alternative route, i.e. oral vitamin C, however, has less bioavailability than infusion (Davis et al 2016). Vitamin C is a chemically active and highly unstable agent against environmental factors such as temperature, pH, light, and oxygen, which shows wide instability in aqueous solutions (Matos-Jr et al 2015, Alvim et al 2016, Fong et al 2016.…”

Liposomal Nanotechnology - A New Frontier for Sport and Exercise Nutrition?

“…Liposomal vitamin C produced higher blood levels of vitamin C than those elicited by unencapsulated vitamin C, but less than that following intravenous vitamin C administration (Figure 2). Moreover all treatments, except placebo, provided equal protection from ischemia-reperfusion injury [21].…”

“…The authors reported that the highest peak plasma level (~ 400 uM/L) was achieved with 36 g, peaking after ~5-6 hours post-ingestion. A more recent study investigated the efficacy of liposomal vitamin C and its effects on ischemia-reperfusion injury [21]. Oral placebo or 4 g of vitamin C via oral unencapsulated, oral liposomal, or intravenous delivery were administered.…”