Liposomal form of dihydroquercetin contributes to skin regeneration after thermal burns

Naumov, Andreas; Potselueva, M. M.

doi:10.1134/s1990519x10030041

Cited by 8 publications

(3 citation statements)

References 5 publications

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“…The antioxidants did not allow the rise in any reactive oxygen species in cells and thus the same level of proteins, uric acid and α-tocopherol is maintained. This formulation was found to be attributed towards reduction of inflammation, necrosis and deepened the formation of oil glands and hair follicles at burnt site (Naumova and Potselueva 2010). Ma et al (2014) Grape seed Vitis vinifera Antioxidant, nutraceutical Kidd (2009) …”

Section: Tissue Regenerationmentioning

confidence: 97%

Liposomal and Phytosomal Formulations

Guliani

Singla

Kumari

et al. 2016

Nanoscale Materials in Targeted Drug Delivery, Theragnosis and Tissue Regeneration

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Liposomes and phytosomes are kind of nanoparticles (NPs) which serve as an imperative tool for the delivery of various bioactive molecules. The molecules possessing lesser water solubility, bioavailability and retention time are encapsulated into both of these formulations. More specifically, liposomes can encapsulate both hydrophobic as well as hydrophilic molecules. While phytosomes contain only plant-based molecules having poor solubility in biological media like flavanones and terpenes. The various advantages of liposomes and phytosomes like biocompatibility, nontoxicity, ease to administer, decrease in dosage and increase in retention time make them potent vehicles for the drug delivery of various molecules. These nanoformulations find potential applications for delivery of various bioactive molecules, in tissue regeneration and as antimicrobials. This chapter highlights the importance of liposomes and phytosomes, methods of their preparation, mechanism of their action and applications.

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Section: Tissue Regenerationmentioning

confidence: 97%

Liposomal and Phytosomal Formulations

Guliani

Singla

Kumari

et al. 2016

Nanoscale Materials in Targeted Drug Delivery, Theragnosis and Tissue Regeneration

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“…None Thermal burn Reduce inflammatory reactions in wound zones; stabilize the endogenous antioxidant system and minimize the area of secondary necrosis of wound; intensify the skin regeneration and repair of hair follicles and sebaceous glands (Naumov and Potselueva, 2010).…”

Section: Lecithin and Glycine Amino Acidmentioning

confidence: 99%

Current status and future outlook of nano‐based systems for burn wound management

et al. 2019

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Wound healing process is a natural and intricate response of the body to its injuries and includes a well-orchestrated sequence of biochemical and cellular phenomena to restore the integrity of skin and injured tissues. Complex nature and associated complications of burn wounds lead to an incomplete and prolonged recovery of these types of wounds. Among different materials and systems which have been used in treating the wounds, nanotechnology driven therapeutic systems showed a great opportunity to improvement and enhancement of the healing process of different type of wounds. The aim of this study is to provide an overview of the recent studies about the various nanotechnology-based management of burn wounds and the future outlook of these systems in this area. Laboratory and animal models for assessing the efficacy of these systems in burn wound management also discussed. K E Y W O R D S burn wound, laboratory and animal models, multicomposites, nanomedicine, nanotechnologybased systems, nanoparticles, scaffolds

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“…Некоторые фармакологические эффекты ДКВ были выявлены как в рамках целенаправленного анализа in silico, так и в полномасштабных трансляционных исследованиях, включающих молекулярное моделирование [8][9]. В последнее время рядом исследователей получены разнообразные формы ДКВ, так называемые физические модификации, характеризующиеся специфической морфологией, различными физико-химическими свойствами и биофармацевтическими параметрами [10][11][12]. К одной из таких модификаций можно отнести микроструктурированную трубчатую форму, синтезированную из фармацевтической субстанции путём осаждения водой из этанольного раствора ДКВ в присутствии мочевины [13].…”

Section: Introductionunclassified

Analysis of dihydroquercetin physical modification via in vitro and in silico methods

et al. 2019

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Flavonoid-mediated materials are promising substances for the design of new functional materials because of their bioactivity, eco-friendliness, and cost-effectiveness. Dihydroquercetin (DHQ) is the major flavonoid in the wood of Larix dahurica Turcz. Previously some new modifications were created on the basis of DHQ, they were characterized by different morphological, physico-chemical and biopharmaceutical properties. This study was performed to research the influence of the solvent on the formation of the solid phase in DHQ microtubes and crystal form as commercially available active pharmaceutical ingredient (API). The choice of the models for the computational simulation was based on the data of differential scanning calorimetry. All calculations were performed using Materials Science Suite. In silico analysis demonstrated that the molecules of solvent are a key player in the formation of the solid phase of the flavonoid-mediated material. Also the comparative analysis of physical characteristics between DHQ microtubes and crystal form was performed. These data give an opportunity to suggest, that DHQ microtubes may have a grate application as the dressing material and in the drug delivering. The results of this study could be helpful for the design of the new flavonoid-mediated materials by crystal engineering.

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Liposomal form of dihydroquercetin contributes to skin regeneration after thermal burns

Cited by 8 publications

References 5 publications

Liposomal and Phytosomal Formulations

Liposomal and Phytosomal Formulations

Current status and future outlook of nano‐based systems for burn wound management

Analysis of dihydroquercetin physical modification via in vitro and in silico methods

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