Liposomal honokiol promotes hair growth via activating Wnt3a/β-catenin signaling pathway and down regulating TGF-β1 in C57BL/6N mice

Li, Shenglan; Chen, Jinyi; Chen, Feng; Guo, Xiaodi; Wang, Can; Fan, Yaqiong; Wang, Yali; Yue, Peng; Li, Wenbin

doi:10.1016/j.biopha.2021.111793

Cited by 24 publications

(25 citation statements)

References 31 publications

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“…Specialized mesenchymal cells, hHFDPC, play a vital role in hair follicle development and hair growth by supporting multi-potent stem cells, cytokines, growth factors, and nutrients [ 24 ]. Synchronized intercellular signaling cascades of hHFDPC and other adjacent cells implicate the hair follicle’s formation, maintenance, and homeostasis [ 7 , 23 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Constitution, Anti-Inflammation, Anti-Androgen, and Hair Growth-Promoting Potential of Shallot (Allium ascalonicum L.) Extract

Ruksiriwanich

Khantham

Muangsanguan

et al. 2022

Plants

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In Thai folklore wisdom, shallot (Allium ascalonicum L.) was applied as a traditional herbal medicine for hair growth promotion with no scientific evidence. Androgenetic alopecia (AGA) is a progressive hair loss caused by multiple factors, including androgen hormones, inflammation, and oxidative stress. Conventional medicines (finasteride, dutasteride, corticosteroids, and minoxidil) have been used with limited therapeutic efficacy and unpleasant side effects. In this study, we aimed to give the first estimation of bioactive compounds in shallot extract and evaluate the hair growth-promoting activities regarding anti-inflammatory and gene expression modulation involving androgen, Wnt/β-catenin, sonic hedgehog, and angiogenesis pathways. The results reveal that phenolic compounds (quercetin, rosmarinic, and p-coumaric acids) are the major constituents of the methanolic shallot extract. Compared with the lipopolysaccharide-stimulated control group (2.68 ± 0.13 µM), nitric oxide production was remarkably diminished by shallot extract (0.55 ± 0.06 µM). Shallot extract improves hair growth promotion activity, as reflected by the downregulation of the androgen gene expression (SRD5A1 and SRD5A2) and the upregulation of the genes associated with Wnt/β-catenin (CTNNB1), sonic hedgehog (SHH, SMO, and GIL1), and angiogenesis (VEGF) pathways. These findings disclose the new insights of shallot extract on hair growth promotions. Shallot extract could be further developed as nutraceutical, nutricosmetic, and cosmeceutical preparations for AGA treatment.

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Section: Discussionmentioning

confidence: 99%

Phytochemical Constitution, Anti-Inflammation, Anti-Androgen, and Hair Growth-Promoting Potential of Shallot (Allium ascalonicum L.) Extract

Ruksiriwanich

Khantham

Muangsanguan

et al. 2022

Plants

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“…The primary WNT includes WNT3, WNT4, and WNT6. WNT3a is only expressed in bulge and decreased in expression during catagen, and not is expressed at all during telogen ( Li et al, 2021 ; Xing et al, 2018 ). Guo et al (2012) found that melanocytes in hair follicles express both WNT3a and β-catenin proteins at the same time.…”

Section: The Molecular Regulation Of Hair Follicle Morphogenesis and ...mentioning

confidence: 99%

Morphogenesis, Growth Cycle and Molecular Regulation of Hair Follicles

Lin

Liang

2022

Front. Cell Dev. Biol.

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As one of the main appendages of skin, hair follicles play an important role in the process of skin regeneration. Hair follicle is a tiny organ formed by the interaction between epidermis and dermis, which has complex and fine structure and periodic growth characteristics. The hair growth cycle is divided into three continuous stages, growth (anagen), apoptosis-driven regression (catagen) and relative quiescence (telogen). And The Morphogenesis and cycle of hair follicles are regulated by a variety of signal pathways. When the signal molecules in the pathways are abnormal, it will affect the development and cycle of hair follicles, which will lead to hair follicle-related diseases.This article will review the structure, development, cycle and molecular regulation of hair follicles, in order to provide new ideas for solving diseases and forming functional hair follicle.

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“…For example, resveratrol liposomes showed protective effects on mitochondria in substantia nigra cells of parkinsonized rats ( Chen et al, 2021 ). Liposomal honokiol has shown various biological activities ( Niu and Gao, 2009 ; Guillermo-Lagae et al, 2017 ; Ong et al, 2020 ; Li et al, 2021b ; Li et al, 2021c ). Liposomal honokiol significantly suppressed Lewis lung carcinoma overexpressing VEGF-D by inhibiting the tumor-associated lymphangiogenesis and metastasis ( Wen et al, 2009 ).…”

Section: Construction Of Liposomal Systems For Medicinal Natural Prod...mentioning

confidence: 99%

Liposomes as Multifunctional Nano-Carriers for Medicinal Natural Products

et al. 2022

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Although medicinal natural products and their derivatives have shown promising effects in disease therapies, they usually suffer the drawbacks in low solubility and stability in the physiological environment, low delivery efficiency, side effects due to multi-targeting, and low site-specific distribution in the lesion. In this review, targeted delivery was well-guided by liposomal formulation in the aspects of preparation of functional liposomes, liposomal medicinal natural products, combined therapies, and image-guided therapy. This review is believed to provide useful guidance to enhance the targeted therapy of medicinal natural products and their derivatives.

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Liposomal honokiol promotes hair growth via activating Wnt3a/β-catenin signaling pathway and down regulating TGF-β1 in C57BL/6N mice

Cited by 24 publications

References 31 publications

Phytochemical Constitution, Anti-Inflammation, Anti-Androgen, and Hair Growth-Promoting Potential of Shallot (Allium ascalonicum L.) Extract

Phytochemical Constitution, Anti-Inflammation, Anti-Androgen, and Hair Growth-Promoting Potential of Shallot (Allium ascalonicum L.) Extract

Morphogenesis, Growth Cycle and Molecular Regulation of Hair Follicles

Liposomes as Multifunctional Nano-Carriers for Medicinal Natural Products

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