Liposomal Vitamin D3 as an Anti-aging Agent for the Skin

Abstract

Vitamin D3 is an effective skin protective substance to prevent photoaging. Liposomes were used as a carrier to deliver vitamin D3 to improve the stability and to enhance the treatment effect of vitamin D3. The stability of vitamin D3 liposomes, average cumulative penetration, and retention of vitamin D3 in the skin were then evaluated and compared with free vitamin D3. Finally, the treatment effect of vitamin D3 liposomes in a rat photoaging model was appraised and Haematoxylin-Eosin (H&E) staining was used to assess the histology changes of the skin after vitamin D3 liposome treatment. The results indicated that liposomes could significantly improve the stability of vitamin D3. The average skin retention of vitamin D3 liposomes was 1.65 times that of the vitamin D3 solution. Vitamin D3 liposomes could repair the surface morphology of skin in the photoaging model and promote the production of new collagen fibers. Vitamin D3 liposomes as a potential skin care agent could significantly improve skin appearance and repair damage in the histology of photoaging.

<p>Development, Characterization and Use of Liposomes as Amphipathic Transporters of Bioactive Compounds for Melanoma Treatment and Reduction of Skin Inflammation: A Review</p>

“…The ethanol is removed by rotary evaporation. 9 Examples of this preparation method are given in Table 1. UDL has been used for vitiligo therapy. 38 In this investigation, liposomes were prepared by ethanol injection and thin-film hydration.…”

“…Both conditions stimulate inflammation and tumorigenesis, which unleash several reactions that promote photoaging since it alters the production of interleukin-10 (IL-10) and interleukin-2 (IL-2), as well as skin cancer by the mutation of the p53 suppressor gene leading the activation of ROS. [8][9][10] Melanoma is a type of skin cancer that occurs in areas barely exposed to the sun. Melanoma tumors are found mainly on the back of men and the legs of women.…”

“…13 Liposomes have been used in the cosmetic and drug industries because they can carry and protect encapsulated substances, improve the solubility of certain substances, and provide controlled drug release. 9 Some liposomes have been prepared for treatment of certain pathologies, such as melanoma, in which their use has a positive effect in reducing tumor size/weight and melanoma cell proliferation. [15][16][17] The objective of this review is to provide an up-to-date description of existing techniques for development and use of liposomes as transporters of bioactive compounds for treatment of melanoma and reduction of skin inflammation.…”

Simil-Microfluidic Nanotechnology in Manufacturing of Liposomes as Hydrophobic Antioxidants Skin Release Systems

“…Some examples are the 86% e.e. found by Bi and collaborators for vitamin D3 entrapped in liposomal vesicles about 100 nm in size to be used as an anti-aging agent for the skin [16]; a 97% e.e. found by Qu and coworkers for vitamin E encapsulated in nanoliposomes about 230 nm in size to be embedded into a chitosan hydrogel and used as a tissue-engineered scaffold [57]; an 82% e.e.…”

“…In another work of Bi and collaborators, a liposomal vitamin D3 formulation to be used as skin anti-aging agent was produced by means of the TFH and EI techniques obtaining, with the last method, more homogeneous vesicles (92 nm in size and 80% e.e. of vitamin D3) but always in small volumes (100 mL) [16].…”