Liposome-based antitubercular drug therapy in a guinea pig model of tuberculosis

Pandey, Rajesh; Sharma, Sadhna; Khuller, G. K.

doi:10.1016/j.ijantimicag.2004.01.002

Cited by 32 publications

(24 citation statements)

References 4 publications

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“…This study was designed to evaluate the potential of using DPPC liposomes as surfactant biomaterials and drug‐delivery systems for antitubercular drugs. Antitubercular drug‐loaded DPPC liposomes developed had encapsulations comparable to the conventional DPPC: cholesterol liposomes had about 22% and 14% entrapment for RFM and INH, respectively 26. Conventional liposomes containing cholesterol inhibit the surface activity of lung surfactants when present in larger amounts 27.…”

Section: Discussionmentioning

confidence: 98%

Evaluation of antitubercular drug‐loaded surfactants as inhalable drug‐delivery systems for pulmonary tuberculosis

Chimote

Banerjee

2008

J Biomedical Materials Res

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Pulmonary tuberculosis is associated with a year-long chemotherapy, poor alveolar drug levels, drug-related systemic toxicity, and patient noncompliance. In this study, exogenous pulmonary surfactant is proposed as a drug carrier for antitubercular drugs. Dipalmitoylphosphatidylcholine (DPPC), the major lung-surfactant lipid, has been combined with antitubercular drugs isoniazid (INH), rifampicin (RFM), and ethambutol (ETH) in 1:1 ratio by weight, in which drugs had a ratio of 1:2:3 by weight. At 37 degrees C, the formulation had better surfactant function with quicker reduction of surface tension on adsorption (32.71 +/- 0.65 mN/m) than DPPC liposomes (44.67 +/- 0.57 mN/m) and maintained 100% airway patency in a capillary surfactometer. Drug-loaded surfactant liposomes were about 2 microm and had entrapment efficiency of 30.04% +/- 2.05%, 18.85% +/- 2.92%, and 61.47% +/- 3.32% for INH, RFM, and ETH, respectively. Sustained release of the drugs from surfactants was observed over 24 h. In vitro alveolar deposition efficiency using the twin impinger showed 12.06% +/- 1.87% of INH, 43.30% +/- 0.87% of RFM, and 22.07% +/- 2.02% of ETH deposited in the alveolar chamber upon nebulization for a minute using a jet nebulizer. The formulation was biocompatible and stable with physicochemical properties being retained even after storage for a month at 4 degrees C. Antitubercular drug-loaded surfactants developed could serve dual purposes of alveolar stabilization due to surfactant action and better reach of these drugs to the alveoli due to antiatelectatic effect of the surfactant.

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Section: Discussionmentioning

confidence: 98%

Evaluation of antitubercular drug‐loaded surfactants as inhalable drug‐delivery systems for pulmonary tuberculosis

Chimote

Banerjee

2008

J Biomedical Materials Res

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“…In recent studies on drug delivery against M. tuberculosis infection, microspheres composed of liposomes or biodegradable polymers such as poly(DL-lactide-co-glycolide) (PLGA) have been used [3]. In these studies, the drugs contained in these carriers showed higher transfer rates and longer half-lifes than free drugs in the organs such as lung [4], liver [5,6], and spleen [7]. The killing effect caused an approximately 1.2-fold decrease in number (log colony forming unit; CFU) of M. tuberculosis in the tissues [5].…”

Section: Introductionmentioning

confidence: 99%

Selective delivery of rifampicin incorporated into poly(dl-lactic-co-glycolic) acid microspheres after phagocytotic uptake by alveolar macrophages, and the killing effect against intracellular Mycobacterium bovis Calmette–Guérin

Yoshida

Matumoto

Hshizume

et al. 2006

Microbes and Infection

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“…dose of liposomal formulation (INH+RIF) was able to maintain the therapeutic levels in the plasma for 4-7 days as against free drugs, which were cleared within 10-12 hour period. The sustained drug release resulted in 12-46 fold higher mean residence time for encapsulated drugs [25]. Weekly therapy with liposomal formulation for 6 weeks produced equivalent clearance of M. tuberculosis from organs as did daily conventional oral therapy with free drugs [26].…”

Section: Multilamellarmentioning

confidence: 99%

Particulate and Vesicular Drug Carriers in the Management of Tuberculosis

Rastogi¹,

Sultana²,

Ali³

et al. 2006

CDD

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Although oral drug therapy for tuberculosis exists and is widely followed, its major drawbacks are lack of patient compliance and development of adverse effects like hepatotoxicity on long term use. Absence of new therapeutic agents and the above mentioned demerits have led to search for alternative methods for delivery of antitubercular agents. Colloidal drug carriers, a popularly utilized delivery system has been deeply explored for the cause. The article discusses the advances in the management of tuberculosis by the use of particulate and vesicular drug carriers by parenteral, inhalational and oral routes. Use of this delivery strategy has led to massive reduction in the dosage resulting in toxicity alleviation. As a number of studies have already been undertaken in experimental models, it will be a promising tool in the prevention of relapse and successful treatment of tuberculosis in patients.

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Liposome-based antitubercular drug therapy in a guinea pig model of tuberculosis

Cited by 32 publications

References 4 publications

Evaluation of antitubercular drug‐loaded surfactants as inhalable drug‐delivery systems for pulmonary tuberculosis

Evaluation of antitubercular drug‐loaded surfactants as inhalable drug‐delivery systems for pulmonary tuberculosis

Selective delivery of rifampicin incorporated into poly(dl-lactic-co-glycolic) acid microspheres after phagocytotic uptake by alveolar macrophages, and the killing effect against intracellular Mycobacterium bovis Calmette–Guérin

Particulate and Vesicular Drug Carriers in the Management of Tuberculosis

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