Liposome-Based Drug Delivery Systems in Cancer Immunotherapy

Abstract

Cancer immunotherapy has shown remarkable progress in recent years. Nanocarriers, such as liposomes, have favorable advantages with the potential to further improve cancer immunotherapy and even stronger immune responses by improving cell type-specific delivery and enhancing drug efficacy. Liposomes can offer solutions to common problems faced by several cancer immunotherapies, including the following: (1) Vaccination: Liposomes can improve the delivery of antigens and other stimulatory molecules to antigen-presenting cells or T cells; (2) Tumor normalization: Liposomes can deliver drugs selectively to the tumor microenvironment to overcome the immune-suppressive state; (3) Rewiring of tumor signaling: Liposomes can be used for the delivery of specific drugs to specific cell types to correct or modulate pathways to facilitate better anti-tumor immune responses; (4) Combinational therapy: Liposomes are ideal vehicles for the simultaneous delivery of drugs to be combined with other therapies, including chemotherapy, radiotherapy, and phototherapy. In this review, different liposomal systems specifically developed for immunomodulation in cancer are summarized and discussed.

Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles

“…Among approaches to modification of mesoporous silica nanoparticles, special attention is paid to the decoration of the carrier surface by a lipid bilayer. These structures of core-shell type allow authors to combine advantages of lipid bilayer based nanovehicles, i.e., liposomes, (biocompatibility, prolongation of drug release, protection of cargo from premature enzymatic decomposition) [2,[244][245][246] and porous silica material (nontoxicity and high encapsulation capability of various cargos). Usually as a material for lipid bilayer fabrication various two-tailed amphiphilic compounds are applied, including 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE); 1,2-distearoylsn-glycero-3-phosphoethanolamine (DSPE); 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC), DPPC and their mixtures in various proportions.…”

Nanotechnology Approaches for Enhanced CNS Drug Delivery in the Management of Schizophrenia

“…Liposomes have versatility in therapeutic applications in immunology, tumour therapy, gene therapy, antiviral therapy, and the most important is drug delivery. 149 Liposomes are composed of biodegradable and biocompatible material, which make them safe for drug delivery. Since liposomes are composed of phosphates, they can easily fuse with a cell's plasma membrane, which is more efficient than pinocytosis.…”

Design of Gelatin-Capped Plasmonic-Diatomite Nanoparticles with Enhanced Galunisertib Loading Capacity for Drug Delivery Applications

“…For this therapeutic agent, nanoscale delivery systems can protect the drug from the liver’s primary mechanism of metabolization, improving their therapeutic effect and reducing the administered dose [ 6 ]. Thanks to the progression of nanotechnology, a variety of nanocarriers have been proposed for disease therapy and diagnosis, including organic, inorganic, and liposome-based nanosystems [ 7 , 8 ].…”