Liposome-Coated Iron Fumarate Metal-Organic Framework Nanoparticles for Combination Therapy

Abstract

One of the main problems for effective treatment of cancer is resistances, which often require combination therapy—for effective treatment. While there are already some potential drug carriers—e.g., liposomes, available for treatment—the effective loading and retention of the desired drug ratio can be challenging. To address this challenge, we propose a new type of drug carrier: liposome-coated metal-organic framework (MOF) nanoparticles. They combine the advantages of liposomes with an easy and efficient loading process. In this work, we present the successful synthesis of liposome-coated MOF nanoparticles via the fusion method. The resulting particles, once loaded, show no premature leakage and an efficient release. Their successful loading with both single and multiple drugs at the same time makes them an interesting candidate for use in combination therapy.

Metal–Organic Framework Nanoparticles

“…In addition to coordination chemistry approaches, external surface functionalization with lipids has also been achieved through electrostatic interactions and solvent‐exchange deposition strategies. [79a,80] For example, with the goal of developing new nanoscale drug delivery vehicles for cancer treatment, Wuttke and co‐workers reported the encapsulation of Fe‐MIL‐88A NPs within exosomes, which are endogenous cell‐derived vesicles composed of phospholipid bilayers . The encapsulation of drug‐loaded MOF NPs was realized using the fusion method, as developed by Liu et al, leading to a versatile drug delivery vehicle with efficient cell uptake and no premature leakage.…”

Encapsulation, Visualization and Expression of Genes with Biomimetically Mineralized Zeolitic Imidazolate Framework‐8 (ZIF‐8)

“…[16] Owing to their high loading capacity, controlled release profiles, biodegradability, and versatile functionality, nanoscale MOFs can serve as a good platform for biological applications. [17][18][19][20][21][22][23][24] A particular attraction of MOFs is their ability to bio-conjugate, infiltrate, and encapsulate biomolecules; thus, nano MOF biocomposites can be prepared with controlled stability and release rates for tailored biological functions. [25][26][27] Zeolitic imidazolate frameworks (ZIFs) are members of the MOF family and are made of zinc ions coordinated by imidazole rings to form topological isomorphs of zeolites.…”

Nanoparticles of Metal‐Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine

“…Numerous strategies have been proposed so far to modify the surface of nanoMOFs using a large variety of molecules, such as nucleic acids, polymers, cyclodextrins (CDs), or lipids, resulting into various degrees of improvement of the particles properties. One can classify these approaches into three categories: covalent, noncovalent, ( Table 2 ) or core–shell, as detailed below.…”