Liposome-embedded SOD attenuated DSS-induced ulcerative colitis in mice by ameliorating oxidative stress and intestinal barrier dysfunction

Abstract

Oxidative stress is generally considered inseparable from the development and exacerbation of ulcerative colitis (UC), therefore, lessening oxidative stress has become a possible way to alleviate UC. In this study,...

Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID

“…The hyperglycemia in non-diabetic COVID‐19 patients could result from impaired pancreatic islet function as well as viral inflammation-induced insulin resistance and abnormal β cell activation 748 , 749 . Oral administration of liposome-embedded SOD (L-SOD) could ameliorate oxidative damage and inflammatory responses via inhibition of myeloperoxidase (MPO) and pro-inflammatory cytokines, as well as protect gut barrier function by promoting the expression of the tight junction proteins occludin and zonula occluden (ZO)-1 in the colon 750 . Furthermore, L-SOD could also reduce OxS to intestinal barrier, thereby ameliorating the vicious circle between hyperglycemia and the oxidative damage 751 .…”

Effect of bovine colostrum liposomes on the bioavailability of immunoglobulin G and their immunoregulatory function in immunosuppressed BALB/c mice

“…Similar results were reported for the improvement of immunity after the encapsulation of liposomes. 41–43 Oh et al in their study suggested that, compared with those not encapsulated by liposomes, the agents encapsulated by liposomes exhibited a superior immune regulatory effect and reduced the inflammation levels in mice ( P < 0.05). 44 In addition, in order to protect the biological activity of superoxide dismutase (SOD), which may be denatured and inactivated due to a high gastric enzyme activity, Zhang and colleagues constructed a liposome embedded with SOD, and the results indicated that compared with those not encapsulated by liposomes, the SOD entrapped by liposomes significantly improved the villus heights and restored the secretion of intestinal cytokines ( P < 0.05), which was consistent with our current results.…”

“…44 In addition, in order to protect the biological activity of superoxide dismutase (SOD), which may be denatured and inactivated due to a high gastric enzyme activity, Zhang and colleagues constructed a liposome embedded with SOD, and the results indicated that compared with those not encapsulated by liposomes, the SOD entrapped by liposomes significantly improved the villus heights and restored the secretion of intestinal cytokines ( P < 0.05), which was consistent with our current results. 43 The immunoglobulins released by differentiated B cells after immune stimulation are important components of humoral immunity, which can neutralize toxins and kill tumor cells and pathogens. 40,45 By determining the immunoglobulins levels, we found that CTX caused significant decreases in the serum and intestine contents of both IgG and IgA; however, the supplementation of BCL increased the IgG and IgA contents to a higher level compared to that by the supplementation of BC alone in the immunosuppressed BALB/c mice (Fig.…”

Effects of coated sodium butyrate on the growth performance, serum biochemistry, antioxidant capacity, intestinal morphology, and intestinal microbiota of broiler chickens

“…Their activity maintains a stable equilibrium between ROS generation and elimination in the bodies of livestock and poultry. SOD is a metalloenzyme ( Zhang et al, 2023 ), T-AOC and GSH-Px are comprehensive indicators of antioxidant substances and capacity in livestock and poultry ( Qin et al, 2022 ), CAT is an enzyme that decomposes hydrogen peroxide into oxygen and water ( Baker et al, 2023 ), and they all play important roles in eliminating ROS in the body, thereby improving the antioxidant capacity of livestock and poultry ( Li et al, 2021 ). MDA activities are often used as a marker of free radicals-induced lipid peroxidation and as an indicator of oxidative damage ( Zhou et al, 2006 ).…”