Liposome-Enabled Synergistic Interaction of Antimicrobial Agents

Schiffelers, Raymond M.; Storm, Gert; Kate, Marian T. ten; Stearne-Cullen, Lorna E. T.; Hollander, Jan G. den; Verbrugh, Henri A.; Bakker-Woudenberg, Irma A. J. M.

doi:10.1081/lpr-120004784

Cited by 14 publications

(9 citation statements)

References 6 publications

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“…It is very likely that the success of liposome chemotherapy is due to this passive targeting; however, targeting is not specific to liposomes, but should be common to all nanoparticle drug delivery schemes. Passive targeting also has been observed in infectious or inflammatory pathologies, as substantial liposome localization at the target site has been demonstrated in a variety of models of infection and inflammation [14]. Long-circulation times have been shown to be linearly related to the degree of target localization in inflammation as well [14].…”

Section: Targetingmentioning

confidence: 97%

“…Both biocompatibility and stability can be imparted on colloidal particles or emulsion droplets by encapsulation within a bilayer membrane; changes in ionic environment that would lead to flocculation would be interrupted by the bilayer, and the size of the flocs would be limited, minimizing sedimentation. The vesosome structure could be used to deliver a cocktail of antibiotics or antimicrobials to sites at a fixed ratio; such mixtures have been shown to act synergistically when delivered in a single liposome [14]. Such multi-drug formulations may be useful to avoid inducing pathogen resistance to a single drug.…”

Section: New Structures -Multiple Membranes For Multiple Tasks and Mumentioning

confidence: 99%

“…a wall k l a i + k 2 d = g pore = (14) κ and are the bend and saddle-splay elastic constants of the bilayer. For many bilayer forming phospholipids, κ and are of order 10 -12 ergs and increase with bilayer thickness, and hence, the chain length of the phospholipids [107 -110].…”

Section: Serum Vs Saline Releasementioning

confidence: 99%

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The Vesosome - A Multicompartment Drug Delivery Vehicle

Kisak¹,

Coldren²,

Evans³

et al. 2004

CMC

159

131

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Assembling structures to divide space controllably and spontaneously into subunits at the nanometer scale is a significant challenge, although one that biology has solved in two distinct ways: prokaryotes and eukaryotes. Prokaryotes have a single compartment delimited by one or more lipid-protein membranes. Eukaryotes have nested-membrane structures that provide internal compartments--such as the cell nucleus and cell organelles in which specialized functions are carried out. We have developed a simple method of creating nested bilayer compartments in vitro via the "interdigitated" bilayer phase formed by adding ethanol to a variety of saturated phospholipids. At temperatures below the gel-liquid crystalline transition, T(m), the interdigitated lipid-ethanol sheets are rigid and flat; when the temperature is raised above T(m), the sheets become flexible and close on themselves and the surrounding solution to form closed compartments. During this closure, the sheets can entrap other vesicles, biological macromolecules, or colloidal particles. The result is efficient and spontaneous encapsulation without disruption of even fragile materials to form biomimetic nano-environments for possible use in drug delivery, colloidal stabilization, or as microreactors. The vesosome structure can take full advantage of the 40 years of progress in liposome development including steric stabilization, pH loading of drugs, and intrinsic biocompatibility. However, the multiple compartments of the vesosome give better protection to the interior contents in serum, leading to extended release of model compounds in comparison to unilamellar liposomes.

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Section: Targetingmentioning

confidence: 97%

Section: New Structures -Multiple Membranes For Multiple Tasks and Mumentioning

confidence: 99%

See 1 more Smart Citation

The Vesosome - A Multicompartment Drug Delivery Vehicle

Kisak¹,

Coldren²,

Evans³

et al. 2004

CMC

159

131

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“…However, there is limited data on coencapsulation of two different drugs in one liposomal formulation 39. Gentamicin and ceftazidime have been coencapsulated into liposomes and the in vivo synergistic effect has been demonstrated by a rat model of pneumonia 40–42. In another study, isoniazid and rifampicin were successfully coencapsulated into liposomes, but no study of beneficial effect was presented 43–45.…”

Section: Introductionmentioning

confidence: 99%

The representation of national political freedom on Web interface design: The indicators

Li¹

2009

J. Am. Soc. Inf. Sci.

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This study is designed to validate 10 Power Distance indicators identified from previous research on cultural dimensions to establish a measurement for determining a country's national political freedom represented on Web content and interface design. Two coders performed content analysis on 156 college/university Web sites selected from 39 countries. One-way analysis of variance was applied to analyze each of the proposed 10 indicators to detect statistical significant differences among means of the three freedom groups (free-country group, partly-free-country group, and not-free-country group). The results indicated that 6 of the 10 proposed indicators could be used to measure a country's national political freedom on Web interface design. The seventh indicator, symmetric layout, demonstrated a negative correlation between the freedom level and the Web representation of Power Distance. The last three proposed indicators failed to show any significant differences among the treatment means, and there are no clear trend patterns for the treatment means of the three freedom groups. By examining national political freedom represented on Web pages, this study not only provides an insight into cultural dimensions and Web interface design but also advances our knowledge in sociological and cultural studies of the Web. IntroductionWith the rapid increase of global communication and economic exchange on the Internet, various regions and communities across the globe are now linked together using this technology. The Internet has become one of the most important vehicles of communication through which we express our opinions and thoughts. A Web page, especially the home page, is one of the most popular means for an organization or a business entity to disseminate its information to the public. It also has become the most important channel through which the organization establishes its own existence and value. As a result, the Web page has grown to be one of the most dependable resources for information-seeking endeavors.As computer-based communication has taken its lead in global information exchange, Web developers and researchers have become aware of the inevitable impact of local culture traits on user interface design. In fact, Web interfaces not only reflect the linguistic aspects (e.g., language, date and time formats) of the country but also represent the culture characteristics (e.g., values, morals, and ethics) of the norm (Ford & Gelderblom, 2003). Therefore, it has become necessary to identify fundamental international cultural dimensions with which local cultural characteristics can be analyzed and compared. In this way, Web designers and analysts are able to design user interfaces in such a way that the Web site coordinates with local cultures to achieve its optimal effects.In response, several cultural models have been developed in culture studies during the past decade (E.T. Hall & Hall, 1989;Hofstede, 2001;Hofstede & Hofstede, 2005;Hoft, 1996;Stewart & Bennett, 1991; Trompenaars & HampdenTurner, 1998). Amon...

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“…39 Gentamicin and ceftazidime have been coencapsulated into liposomes and the in vivo synergistic effect has been demonstrated by a rat model of pneumonia. [40][41][42] In another study, isoniazid and rifampicin were successfully coencapsulated into liposomes, but no study of beneficial effect was presented. [43][44][45] To date, no studies have coencapsulated FLU/MTO nor demonstrated therapeutic benefit of such a combination.…”

Section: Introductionmentioning

confidence: 99%