Liposomes as cytokine-supplement in tumor cell-based vaccines

Slooten, M. L. van; Kircheis, Ralf; Koppenhagen, Frank J.; Wagner, Ernst; Storm, Gert

doi:10.1016/s0378-5173(99)00039-3

Cited by 10 publications

(7 citation statements)

References 11 publications

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“…In particular, liposomes have been used as carriers for many kinds of molecules such as anti-cancer [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25], antibacterial [26][27][28][29], anti-fungal [30,31] and anti-viral [32,33] agents, and bioactive macromolecules [34][35][36][37][38][39].…”

Section: Liposomesmentioning

confidence: 99%

Liposome-Nanogel Structures for Future Pharmaceutical Applications

Казаков¹,

Levón²

2006

CPD

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Nanoparticles have been extensively studied as drug delivery systems. In this review, we focus on a relatively new type of nanoparticles--lipobeads--a liposome-hydrogel assembly as a novel drug delivery system. An appropriate assemblage of spherical hydrogel particles and liposomes combines the properties of both classes of materials and may find a variety of biomedical applications. The bi-compartmental structure of lipobeads is a natural configuration. Thus, the technology of their preparation can be a key step of designing more stable and effective vaccines. Biocompatibility and stability, ability to deliver a broad range of bioactive molecules, environmental responsiveness of both inner nanogel core and external lipid bilayer, and individual specificity of both compartments make the liposome-nanogel design a versatile drug delivery system relevant for all known drug administration routes and suitable for different diseases with possibility of efficient targeting to different organs. New findings on reversible and irreversible aggregation of lipobeads can lead to novel combined drug delivery systems regarding lipobeads as multipurpose containers. The research on hydrogel-liposome submicrometer structures has just begun and fundamental studies on interactions between hydrogels and liposomes are in demand.

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Section: Liposomesmentioning

confidence: 99%

Liposome-Nanogel Structures for Future Pharmaceutical Applications

Казаков¹,

Levón²

2006

CPD

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“…The complete clearance requires the intra-venous administration for acute phase followed by prolonged oral therapy in case of such infections. Liposomes have also been used successfully for delivering superoxide dismutase [34], hemoglobin [35], tumor necrosis factor [36], erythropoietin [37], interleukin-2 and interferon- [38]. The liposomal administration also prolongs duration of analgesia without any increase of side effects [39].…”

Section: Liposome Technology; Progress and Achievementsmentioning

confidence: 99%

Drug Carriers in Pharmaceutical Design: Promises and Progress

Dutta¹

2007

CPD

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Ever since pure molecular entities have been adapted as drug, varied manifestations other than elimination of infections are frequently been acknowledged as side effects. Contemporary drug research focuses on these issues besides developing new molecules for the restoration of unnatural functional deviations in various tissues and organs. The most promising advancement to achieve this concept of ideal drug is the encapsulation of drug in biocompatible nano or microspheres. Encapsulation can insulate the toxic drugs and lease a better half life to molecules undergoing spontaneous degradation under physiological conditions. It is also worthwhile to incorporate along some immunomodulators to strengthen and channelize the innate immune response of the host in right direction. This holistic approach would also prevent the physiological modulations dictated by invading pathogens, which paralyze the important functionaries of the host. Lipoproteins, lipid like molecules and probiotic non-colonizing bacterial membrane mimics might prove to be the best ingredients for encapsulation. Some synthetic non-immunogenic supra molecules like fullarenes and dendrimers also exhibit great potential for the development of new encapsulation technology. Here an attempt is made to review the progress in terms of aims and achievements in the area of drug carriers and encapsulation with its overall impact on therapeutic industry.

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“…Therefore, liposomes have been used for delivering superoxide dismutase [37], hemoglobin [38], tumor necrosis factor [39], erythropoietin [40], interleukin-2, and interferon-γ [41]. In most of the applications mentioned above, liposomes were systemically administered.…”

Section: Liposomal Applications In Ddsmentioning

confidence: 99%

Evaluation of Drug Targeting Strategies and Liposomal Trafficking

Oku¹,

Tokudome²,

Asai³

et al. 2000

CPD

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Liposomes, that are biodegradable and essentially non-toxic, can encapsulate both hydrophilic and hydrophobic materials, and are utilized as drug carriers for drug delivery systems (DDS). Recent progress in gene technology provides a novel modality of therapy for various diseases with a variety of newlydeveloped cationic liposomes. Delivery of agents to the reticuloendothelial system (RES) is easily achieved since most conventional liposomes are trapped by the RES. For the purpose of delivery of agents to target organs other than RES, long-circulating liposomes have been developed by modifying the liposomal surface. Understanding of the in vivo dynamics of liposome-carried agents is required to evaluate the bioavailability of drugs encapsulated in liposomes. In this review, we focus on the in vivo trafficking of liposomes visualized by positron emission tomography (PET) and discuss the characteristics of liposomes that affect the targeting of drugs in vivo.

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Liposomes as cytokine-supplement in tumor cell-based vaccines

Cited by 10 publications

References 11 publications

Liposome-Nanogel Structures for Future Pharmaceutical Applications

Liposome-Nanogel Structures for Future Pharmaceutical Applications

Drug Carriers in Pharmaceutical Design: Promises and Progress

Evaluation of Drug Targeting Strategies and Liposomal Trafficking

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