Liposomes-coated gold nanocages with antigens and adjuvants targeted delivery to dendritic cells for enhancing antitumor immune response

Liang, Ruijing; Xie, Jun; Li, Jun; Wang, Ke; Liu, Liping; Gao, Yujie; Hussain, Mubashir; Shen, Guanxin; Zhu, Jintao; Tao, Juan

doi:10.1016/j.biomaterials.2017.09.029

Cited by 149 publications

(92 citation statements)

References 36 publications

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“…It is likely that TRP2 was successfully encapsulated within EXOs via pore formation in the EXO membranes by saponin during incubation. Although the loading efficiency of TRP2 was not greater than those from previous studies that used zinc phosphate nanoparticles and liposome‐coated gold nanoparticles, our study is the first report of a peptide antigen loading method for TRP2 within EXOs via saponin incubation.…”

contrasting

confidence: 66%

“…In previous studies, melanoma antigen peptide TRP2 was incorporated into polymeric nanoparticles, inorganic nanoparticles, and liposomes and then delivered into lymph nodes for antitumor immunity . In the present study, serum‐derived EXOs were utilized for the delivery of peptide antigen TRP2 into lymph nodes.…”

mentioning

confidence: 95%

“…As a result, it may be beneficial to develop carrier systems for delivering peptide antigens to immune cells . To improve the biological performance of peptide antigens as cancer vaccines, biomaterials such as nanoparticles, microparticles, and hydrogels have been used to encapsulate peptides . In particular, nanosized particles have been designed that can deliver antigens and immune stimulators to lymph nodes .…”

mentioning

confidence: 99%

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Efficient Delivery of Tyrosinase Related Protein‐2 (TRP2) Peptides to Lymph Nodes using Serum‐Derived Exosomes

Park

Choi

et al. 2018

Macromolecular Bioscience

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Exosomes (EXO) are considered to be versatile carriers for biomolecules; however, the delivery of therapeutic peptides using EXOs poses several challenges. In this study, the efficiency of serum‐derived EXOs in delivering tyrosinase‐related protein‐2 (TRP2) peptides to lymph nodes is determined. TRP2 peptides are successfully incorporated into EXOs, which show a uniform and narrow size distribution of around 45 nm. The TRP2‐incorporated exosomes (EXO‐TRP2) are efficiently internalized into macrophages and dendritic cells, and are seen to display a punctate distribution. EXOs loaded with TRP2 together with MPLA, (EXO‐MPLA‐TRP2) result in a strong release of proinflammatory cytokines (TNF‐α and IL‐6) from both RAW264.7 and DC2.4 cells. Finally, subcutaneous injection of fluorescently labeled EXO‐TRP2 followed by ex vivo imaging using in vivo imaging system (IVIS) show a strong fluorescent signal in the lymph nodes after only 1 h, which is maintained until at least 4 h after injection. Taken together, the findings suggest that serum‐derived EXOs can serve as promising carriers to deliver therapeutic peptides to lymph nodes for immunotherapy.

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confidence: 66%

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confidence: 95%

mentioning

confidence: 99%

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Efficient Delivery of Tyrosinase Related Protein‐2 (TRP2) Peptides to Lymph Nodes using Serum‐Derived Exosomes

Park

Choi

et al. 2018

Macromolecular Bioscience

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“…In addition, AuNPs can attain high photothermal conversion effect upon laser illumination and are highly biocompatible, have good chemical inertness, excellent physiochemical properties, and a high extinction coefficient . AuNPs have been synthesized as nanorods, nanoprisms, nanocages, nanospheres, nanostars, nanodisks, bipyramids and rhombic dodecahedra, nanoplates, nanoshells, nanotripods, and nanowreaths …”

Section: Inorganic Contrast Agentsmentioning

confidence: 99%

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

et al. 2018

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Photoacoustic (PA) imaging as a fast‐developing imaging technique has great potential in biomedical and clinical applications. It is a noninvasive imaging modality that depends on the light‐absorption coefficient of the imaged tissue and the injected PA‐imaging contrast agents. Furthermore, PA imaging provides superb contrast, super spatial resolution, and high penetrability and sensitivity to tissue functional characteristics by detecting the acoustic wave to construct PA images. In recent years, a series of PA‐imaging contrast agents are developed to improve the PA‐imaging performance in biomedical applications. Here, recent progress of PA contrast agents and their biomedical applications are outlined. PA contrast agents are classified according to their components and function, and gold nanocrystals, gold‐nanocrystal assembly, transition‐metal chalcogenides/MXene‐based nanomaterials, carbon‐based nanomaterials, other inorganic imaging agents, small organic molecules, semiconducting polymer nanoparticles, and nonlinear PA‐imaging contrast agents are discussed. The applications of PA contrast agents as biosensors (in the sensing of metal ions, pH, enzymes, temperature, hypoxia, reactive oxygen species, and reactive nitrogen species) and in bioimaging (lymph nodes, vasculature, tumors, and brain tissue) are discussed in detail. Finally, an outlook on the future research and investigation of PA‐imaging contrast agents and their significance in biomedical research is presented.

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“…As is well known, DCs, the most powerful APCs, initiate and regulate humoral and cellular immune responses, so target delivery to DCs can be achieved by conjugating targeting ligands onto the surface of antigen‐loaded nanoparticles. These ligands specifically bind to the surface receptors expressed by DCs, such as mannose, DEC‐205, CD40, CD11c, and DC‐SIGN receptors . Such delivery systems have indeed enhanced DCs engulfment in comparison to their nontarget counterparts.…”

Section: Nanomaterials For Target Deliverymentioning

confidence: 99%

Nanoparticle‐Based Nanomedicines to Promote Cancer Immunotherapy: Recent Advances and Future Directions

Liu

Zhang

2019

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Cancer immunotherapy is a promising cancer terminator by directing the patient's own immune system in the fight against this challenging disorder. Despite the monumental therapeutic potential of several immunotherapy strategies in clinical applications, the efficacious responses of a wide range of immunotherapeutic agents are limited in virtue of their inadequate accumulation in the tumor tissue and fatal side effects. In the last decades, increasing evidences disclose that nanotechnology acts as an appealing solution to address these technical barriers via conferring rational physicochemical properties to nanomaterials. In this Review, an imperative emphasis will be drawn from the current understanding of the effect of a nanosystem's structure characteristics (e.g., size, shape, surface charge, elasticity) and its chemical modification on its transport and biodistribution behavior. Subsequently, rapid‐moving advances of nanoparticle‐based cancer immunotherapies are summarized from traditional vaccine strategies to recent novel approaches, including delivery of immunotherapeutics (such as whole cancer cell vaccines, immune checkpoint blockade, and immunogenic cell death) and engineered immune cells, to regulate tumor microenvironment and activate cellular immunity. The future prospects may involve in the rational combination of a few immunotherapies for more efficient cancer inhibition and elimination.

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Liposomes-coated gold nanocages with antigens and adjuvants targeted delivery to dendritic cells for enhancing antitumor immune response

Cited by 149 publications

References 36 publications

Efficient Delivery of Tyrosinase Related Protein‐2 (TRP2) Peptides to Lymph Nodes using Serum‐Derived Exosomes

Efficient Delivery of Tyrosinase Related Protein‐2 (TRP2) Peptides to Lymph Nodes using Serum‐Derived Exosomes

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

Nanoparticle‐Based Nanomedicines to Promote Cancer Immunotherapy: Recent Advances and Future Directions

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