Liposomes: Current Approaches for Development and Evaluation

Abstract

Liposomes (50-1000nm) are the part of a specific type of drug delivery system which is non-toxic and biodegradable in nature. That having ability to reduce the toxicity also enhances the therapeutic efficiency and protects the drug which is encapsulated, from the degradation and immediate dilution. These can be prepared by using various techniques like lipid hydration method, sonication method and solvent injecting method etc. But the selection of technique is depended upon the size of liposome which we want. The main disadvantage of this dosage form is it is very much costly and also having time consuming process. But it has major applications in the form of extrusion for homogeneous size, long circulating liposomes, triggered release liposome, remote drug loading, ligand targeted liposomes and containing combination of drugs. These applications are helpful for advanced drug delivery of anticancer, antifungal and anti-inflammatory drug, the delivery of gene medicine, delivery of anaesthetic and antibiotic drug. The newer researches in this field include hybrid liposomes, phototrigerable liposomes which are fabricated to have the improved functionality. These serves as the upcoming novel nanomedicinal chemotherapy technique.

Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature

“… 140 Methods of microscopy are generally of high resolution and rapid productivity, but the sample preparation is complicated and time-consuming; also, some problems such as shrinking or shape distortion can be generated in sample preparation. 141 The measurement of phytosome size distribution and polydispersity gives data on their physical stability, which can be evaluated by DLS. 142 DLS is easy, precise, accurate, very fast and can therefore be used for regular size distribution measurements of phytosomes.…”