Liposomes for Antibiotic Encapsulation and Delivery

Gómez, Azucena González; Hosseinidoust, Zeinab

doi:10.1021/acsinfecdis.9b00357

Cited by 109 publications

(60 citation statements)

References 129 publications

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“…Liposomes are vesicular concentric bilayer structures composed of relatively biocompatible and biodegradable materials. They offer several advantages over other delivery systems due to their unique characteristics to incorporate hydrophilic and hydrophobic drugs, biocompatibility, biodegradability, low toxicity and lack of immune system activation [14,20,21]. In addition, liposomes can be easily coupled with targeting platforms, such as antibodies, proteins or enzymes, thus allowing a specific delivery of bioactive compounds directly into infection sites [22][23][24][25].…”

Section: Nanotechnological Approaches For Treatment Of Bacterial Infectionsmentioning

confidence: 99%

“…Among the wide array of nanoplatforms, one of the most promising delivery approaches for antibiotics under investigation are liposomes [12,13]. These lipid-based nano-systems were introduced as drug carriers in the 1970s, and, since then, major breakthroughs in liposome technology have driven the interest of their use as efficient delivery systems for antibacterial drugs [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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Liposomes as Antibiotic Delivery Systems: A Promising Nanotechnological Strategy against Antimicrobial Resistance

et al. 2021

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Antimicrobial drugs are key tools to prevent and treat bacterial infections. Despite the early success of antibiotics, the current treatment of bacterial infections faces serious challenges due to the emergence and spread of resistant bacteria. Moreover, the decline of research and private investment in new antibiotics further aggravates this antibiotic crisis era. Overcoming the complexity of antimicrobial resistance must go beyond the search of new classes of antibiotics and include the development of alternative solutions. The evolution of nanomedicine has allowed the design of new drug delivery systems with improved therapeutic index for the incorporated compounds. One of the most promising strategies is their association to lipid-based delivery (nano)systems. A drug’s encapsulation in liposomes has been demonstrated to increase its accumulation at the infection site, minimizing drug toxicity and protecting the antibiotic from peripheral degradation. In addition, liposomes may be designed to fuse with bacterial cells, holding the potential to overcome antimicrobial resistance and biofilm formation and constituting a promising solution for the treatment of potential fatal multidrug-resistant bacterial infections, such as methicillin resistant Staphylococcus aureus. In this review, we aim to address the applicability of antibiotic encapsulated liposomes as an effective therapeutic strategy for bacterial infections.

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Section: Nanotechnological Approaches For Treatment Of Bacterial Infectionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Liposomes as Antibiotic Delivery Systems: A Promising Nanotechnological Strategy against Antimicrobial Resistance

et al. 2021

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“…Additionally, membrane-bound NPs can encapsulate amphiphilic, hydrophobic, and hydrophilic drugs, but primarily lipophilic antibiotics ( Lee and Thompson, 2017 ; Caminade, 2014 ). The lipid bilayer of liposomes can encapsulate lipophilic antibiotics at the desired concentration and deliver them to the infection site without losing their potency and exerting undue toxicity ( Gonzalez Gomez and Hosseinidoust, 2020 ). Therefore, liposomal delivery reduces antibiotics’ footprint in the environment, a crucial factor that can limit the evolution of antibiotic resistance in bacterial mutant strains in the environment ( Hocquet et al, 2016 ).…”

Section: Nanoparticle-functionalized Antibiotics (Nabts)mentioning

confidence: 99%

Nanoantibiotics: Functions and Properties at the Nanoscale to Combat Antibiotic Resistance

et al. 2021

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One primary mechanism for bacteria developing resistance is frequent exposure to antibiotics. Nanoantibiotics (nAbts) is one of the strategies being explored to counteract the surge of antibiotic resistant bacteria. nAbts are antibiotic molecules encapsulated with engineered nanoparticles (NPs) or artificially synthesized pure antibiotics with a size range of ≤100 nm in at least one dimension. NPs may restore drug efficacy because of their nanoscale functionalities. As carriers and delivery agents, nAbts can reach target sites inside a bacterium by crossing the cell membrane, interfering with cellular components, and damaging metabolic machinery. Nanoscale systems deliver antibiotics at enormous particle number concentrations. The unique size-, shape-, and composition-related properties of nAbts pose multiple simultaneous assaults on bacteria. Resistance of bacteria toward diverse nanoscale conjugates is considerably slower because NPs generate non-biological adverse effects. NPs physically break down bacteria and interfere with critical molecules used in bacterial processes. Genetic mutations from abiotic assault exerted by nAbts are less probable. This paper discusses how to exploit the fundamental physical and chemical properties of NPs to restore the efficacy of conventional antibiotics. We first described the concept of nAbts and explained their importance. We then summarized the critical physicochemical properties of nAbts that can be utilized in manufacturing and designing various nAbts types. nAbts epitomize a potential Trojan horse strategy to circumvent antibiotic resistance mechanisms. The availability of diverse types and multiple targets of nAbts is increasing due to advances in nanotechnology. Studying nanoscale functions and properties may provide an understanding in preventing future outbreaks caused by antibiotic resistance and in developing successful nAbts.

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“…Liposomes are self-assembled lipid vesicles with an inner aqueous compartment, which are formed by the directional arrangement of phospholipid molecules. 26 The unique structural features enable them to encapsulate both hydrophobic and hydrophilic drugs. 27,28 What’s more, phospholipid and cholesterol, as materials for liposomes, are the main components of biological cell membrane, have good biocompatibility, degradability and low toxicity.…”

Section: Introductionmentioning

confidence: 99%

PEG-α-CD/AM/liposome @amoxicillin double network hydrogel wound dressing—Multiple barriers for long-term drug release

Wang

et al. 2021

J Biomater Appl

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Wound infection and poor wound healing are the major challenges of wound treatment. Antibiotic drug treatment is the effective way to inhibit wound infection. It is necessary to achieve sustained release of antibiotics to get a longer treatment for wound infection. The double network hydrogels based on liposome, polyethylene glycol (PEG), α- cyclodextrin ( α-CD) and acrylamide (AM) were developed, in which liposome acts as amoxicillin repository. Because the drug would release from the multiple barriers including two cavities of liposome and α-CD, as well as polyethylene glycol - α- cyclodextrin/acrylamide (PEG-CD/AM) double network, the PEG- α-CD/AM/liposome @amoxicillin double network hydrogels could achieve sustained drug release. The drug release assay showed that the dressing could release amoxicillin continuously until 12 days, than that of 8th day for single-network hydrogel releasing. The antibacterial ratio of the hydrogel could reach above 80%. What’s more, the hydrogels present adjustable mechanical strength by changing the ratio of the components. The swelling ratio proved that the hydrogel had potential ability to absorb wound exudates. The cytotoxicity test of the hydrogels demonstrated excellent biocompatibility. These results indicated that this study can provide a new thought for antibacterial wound dressing and has a broad application prospect.

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Liposomes for Antibiotic Encapsulation and Delivery

Cited by 109 publications

References 129 publications

Liposomes as Antibiotic Delivery Systems: A Promising Nanotechnological Strategy against Antimicrobial Resistance

Liposomes as Antibiotic Delivery Systems: A Promising Nanotechnological Strategy against Antimicrobial Resistance

Nanoantibiotics: Functions and Properties at the Nanoscale to Combat Antibiotic Resistance

PEG-α-CD/AM/liposome @amoxicillin double network hydrogel wound dressing—Multiple barriers for long-term drug release

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